Adam's Curse

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Adam's Curse: A Future Without Men (also known as Adam's Curse: A Story of Sex, Genetics, and the Extinction of Men) is a 2003 book by Oxford University human genetics professor Bryan Sykes expounding his hypothesis that with the declining sperm count in men and the continual atrophy of the Y chromosome, within 5,000 generations (approximately 125,000 years) men shall become extinct.

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Sykes thinks one of the options for man's survival is unisex reproduction by females: female eggs fertilised by the nuclear X chromosomes of another female and implanted using in vitro fertilisation methods. He also introduces the possibility of moving the SRY and associated genes responsible for maleness and male fertility to another chromosome, which he refers to as "the Adonis chromosome", engendering fertile males with an XX karyotype.

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Sex specialization of organisms into male or female varieties

Sex is the attribute of male or female in organisms that propagate the species through sexual reproduction. Many plants and almost all animals employ sexual reproduction. Animals are usually mobile and seek out a partner of the opposite sex for mating. Animals which live in the water can mate using external fertilization, whereas most land-based animals, such as reptiles, birds, and mammals, including humans, use internal fertilization. Plants are generally immobile, and in seed plants sexual reproduction relies on pollination, either through self-pollination, or via cross-pollination with other plants of the same species.

Fertilisation Union of gametes of opposite sexes during the process of sexual reproduction to form a zygote

Fertilisation or fertilization, also known as generative fertilisation, syngamy and impregnation, is the fusion of gametes to give rise to a new individual organism or offspring and initiate its development. Processes such as insemination or pollination which happen before the fusion of gametes are also sometimes informally called fertilization. The cycle of fertilisation and development of new individuals is called sexual reproduction. During double fertilisation in angiosperms the haploid male gamete combines with two haploid polar nuclei to form a triploid primary endosperm nucleus by the process of vegetative fertilisation.

XY sex-determination system Sex-determination system

The XY sex-determination system is a sex-determination system used to classify many mammals, including humans, some insects (Drosophila), some snakes, some fish (guppies), and some plants. In this system, the sex of an individual is determined by a pair of sex chromosomes. Females typically have two of the same kind of sex chromosome (XX), and are called the homogametic sex. Males typically have two different kinds of sex chromosomes (XY), and are called the heterogametic sex.

Sex-determination system Biological system that determines how we determine the sexual characteristics in an organism

A sex-determination system is a biological system that determines the development of sexual characteristics in an organism. Most organisms that create their offspring using sexual reproduction have two sexes. Occasionally, there are hermaphrodites in place of one or both sexes. There are also some species that are only one sex due to parthenogenesis, the act of a female reproducing without fertilization.

Mitochondrial Eve

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Y chromosome

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Male Sex of an organism which produces sperm

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XX male syndrome Rare congenital condition where an individual with an 46, XX karyotype has phenotypically male characteristics that can vary between cases

XX male syndrome, also known as de la Chapelle syndrome, is a rare congenital intersex condition in which an individual with a 46, XX karyotype has phenotypically male characteristics that can vary among cases. Synonyms include 46,XX testicular difference of sex development, 46,XX sex reversal, nonsyndromic 46,XX testicular DSD, and XX sex reversal.

Heterogametic sex

Heterogametic sex refers to the sex of a species in which the sex chromosomes are not the same. For example, in humans, males, with an X and a Y sex chromosome, would be referred to as the heterogametic sex, and females having two X sex chromosomes would be referred to as the homogametic sex.

Sex chromosome Chromosome that differs from an ordinary autosome in form, size, and behavior

A sex chromosome, is a chromosome that differs from an ordinary autosome in form, size, and behavior. The human sex chromosomes, a typical pair of mammal allosomes, determine the sex of an individual created in sexual reproduction. Autosomes differ from allosomes because autosomes appear in pairs whose members have the same form but differ from other pairs in a diploid cell, whereas members of an allosome pair may differ from one another and thereby determine sex.

Hereditary carrier

A hereditary carrier, is a person or other organism that has inherited a recessive allele for a genetic trait or mutation but usually does not display that trait or show symptoms of the disease. Carriers are, however, able to pass the allele onto their offspring, who may then express the genetic trait.

Patricia Ann Jacobs OBE FRSE FRS FMedSci FRCPath is a Scottish geneticist and is Honorary Professor of Human Genetics, Co-director of Research, Wessex Regional Genetics Laboratory, within the University of Southampton.

Female Sex of an organism which produces ova

Female is the sex of an organism, or a part of an organism, that produces non-mobile ova. Barring rare medical conditions, most female mammals, including female humans, have two X chromosomes. Female characteristics vary between different species with some species containing more well defined female characteristics, such as the presence of pronounced mammary glands. There is no single genetic mechanism behind sex differences in different species and the existence of two sexes seems to have evolved multiple times independently in different evolutionary lineages.

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