Adele Green | |
---|---|
Born | Adele Chandler Green 20 September 1952 Cairns, Queensland, Australia |
Nationality | Australian |
Known for | Research into melanoma |
Scientific career | |
Fields | Epidemiology |
Institutions | QIMR Berghofer Medical Research Institute |
Adele Chandler Green (born 20 September 1952) [1] [2] is an Australian epidemiological senior scientist at the QIMR Berghofer Medical Research Institute in Brisbane and is the institute's Head of Cancer and Population Studies Group.
Green is an international leader in the epidemiology of melanoma and skin cancer. [3] She is best known for her contributions to the area of melanoma prevention, for which in 2013 she received the Queensland Australian of the Year Award and The Australian Financial Review and Westpac 100 Women of Influence Award.
Green was educated at the University of Queensland medical school in the 1970s. Despite considering a career in English literature or diplomatic service, she chose medicine due to her interest in biology, as well as being influenced by well-known female scientists such as Marie Curie. [4] She received 1st class honours in Medicine and worked as a clinician for several years before receiving her PhD in epidemiology in 1984 from the University of Queensland. Green also holds an M.Sc. from the London School of Hygiene and Tropical Medicine.
In 1986, Green began her 20-year [5] landmark study in the rural Queensland town of Nambour of sunscreen usage, where half of 1621 participants applied sunscreen daily and the rest maintained previous sporadic sunscreen application habits. These participants were followed initially for 10 years, with the results showing the application of sunscreen halved the chance of developing melanoma. This ground-breaking randomised controlled trial of long-term sunscreen application in an Australian community provided the scientific basis for clinical and public health advice about sunscreen use for skin cancer prevention. [6]
Her other significant contributions include insight into risk factors for ovarian cancer and into the burden of cancer in Indigenous Australians. Green has received international awards and is a recognised advocate for cancer control, including through longstanding membership on national and international scientific and advisory councils. She has trained and mentored a generation of epidemiologists and clinician-scientists. Green has also done research into other cancers, such as esophageal cancer and ovarian cancer. Studies of these cancers occurred in 2008 in the research project 'Towards Cancer Control — population and molecular strategies'. [7]
In 1985, using a Neil Hamilton Fairley Postdoctoral Travelling Fellowship awarded by the Australian National Health and Medical Research Council (NHMRC), she travelled to the UK, where at the London School of Hygiene & Tropical Medicine she earned an MSc in Epidemiology. During this time she also served as a visiting Lecturer in Medicine at Harvard Medical School, Boston, USA. Green joined QIMR's Epidemiology and Population Health Unit in 1996 and was appointed a Senior Principal Research Fellow. She was the visiting medical research officer at the Wellcome Trust in London in 1997. From 2000 - 2011 Green acted as the deputy director to QIMR. During this time period she simultaneously operated in a variety of roles: in 2000 as the Head of Cancer and Population Studies Group in QIMR, in 2002 as a professor at both the University of Queensland and the Queensland University of Technology. In 2005 she was appointed as an adjunct professor at Griffith University and in 2009 as a professor at the Institute of Inflammation and Repair, as well as at the University of Manchester. In 2010 she was appointed as the acting director of QIMR. In 2014 she served as a senior research scientist at the Cancer Research UK Manchester Institute at the University of Manchester. She is currently a senior scientist at QIMR, a position she has held since 2012. [8]
Green has served on many Australian research bodies, such as the Australian Cancer Research Foundation's Medical Research Advisory Committee, the National Public Health Partnership, and the National Health and Medical Research Council and was Chair of the NHMRC's Health Advisory Committee (2000-2005). Apart from Australian research bodies, she has also served on many committees at the International Agency for Research on Cancer (IARC) in Lyon, France. These have included: Chair of the Working Group on Artificial UV and Skin Cancer in 2005, member of the Working Group on Code of Good Practice for IARC Researchers (2006-2008), and member of the Working Party for the Monograph on Radiation and Cancer in 2009. Green also serves as a member of the International Commission on Non-Ionising Radiation Protection and its Epidemiology Standing Committee. [9]
In her 20s she was self-proclaimed "sun-worshipper". [4] Green hikes as a hobby. [4] She is a mother. [10]
Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. It occurs when skin cells grow uncontrollably, forming malignant tumors. The primary cause of skin cancer is prolonged exposure to ultraviolet (UV) radiation from the sun or tanning devices. Skin cancer is the most commonly diagnosed form of cancer in humans. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin that may be shiny with small blood vessels running over it or may present as a raised area with an ulcer. Squamous-cell skin cancer is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds.
The QIMR Berghofer Medical Research Institute is an Australian medical research institute located in Herston, Brisbane, in the state of Queensland. QIMR was established in 1945 by the Government of Queensland through the enactment of the Queensland Institute of Medical Research Act 1945 (Qld). Previously known as the Queensland Institute of Medical Research (QIMR), the original purpose of the institute was to further the study of tropical diseases in North Queensland. The current director is Professor Fabienne Mackay. The institute is a registered charity. In 2021, the institute was named as one of the Queensland Greats by the Queensland Government.
Michael F. Good was the Director of the Queensland Institute of Medical Research, from 2000 to 2010. He was Chair of the National Health and Medical Research Council.
Ian Hector Frazer is a Scottish-born Australian immunologist, the founding CEO and Director of Research of the Translational Research Institute (Australia). Frazer and Jian Zhou developed and patented the basic technology behind the HPV vaccine against cervical cancer at the University of Queensland. Researchers at the National Cancer Institute, Georgetown University, and University of Rochester also contributed to the further development of the cervical cancer vaccine in parallel.
Nicholas Gordon Martin is an Australian behavior geneticist who has published over 1300 peer-reviewed articles on topics including the heritability of religion and intelligence and medical disorders such as endometriosis. Martin is among the most cited medical scientists in the Southern Hemisphere, with a number of citation classics including "Genes, culture and personality: An empirical approach" that he co-authored with Lindon Eaves and Hans Eysenck, "Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus" (Nature, and "Genetic and environmental contributions to alcohol dependence risk in a national twin sample".
Sunburn is a form of radiation burn that affects living tissue, such as skin, that results from an overexposure to ultraviolet (UV) radiation, usually from the Sun. Common symptoms in humans and other animals include red or reddish skin that is hot to the touch or painful, general fatigue, and mild dizziness. Other symptoms include blistering, peeling skin, swelling, itching, and nausea. Excessive UV radiation is the leading cause of (primarily) non-malignant skin tumors, which in extreme cases can be life-threatening. Sunburn is an inflammatory response in the tissue triggered by direct DNA damage by UV radiation. When the cells' DNA is overly damaged by UV radiation, type I cell-death is triggered and the tissue is replaced.
Georgia Chenevix-Trench is an Australian cancer researcher who investigates genetic predispositions to cancer.
Eleanor Josephine Macdonald was a pioneer American cancer epidemiologist and cancer researcher influenced and mentored by Edwin Bidwell Wilson and Shields Warren. One of the earliest proponents of the idea that cancer was a preventable disease. She established the first cancer registry in the United States in Connecticut.
Skin cancer in Australia kills over 2,000 each year, with more than 750,000 diagnosed and treated. Tanning became embedded in Australian culture and proved to be a controversial issue because of its popularity among teens and solarium users, despite correlations between tanning and an increased risk of developing melanoma. Australia experienced relative success through skin cancer prevention campaigns started in the 1980s and continued to invest and promote awareness through government-funded mass media strategies. Although Australia has one of the highest national rates of skin cancer, mortality trends in melanoma stabilized.
Health Translation Queensland is the first Advanced Health Research Translation Centre in Queensland, Australia.
Frank Gannon is a molecular biologist, and was the seventh Director of QIMR Berghofer Medical Research Institute in Brisbane, Australia. He has held high-profile appointments in scientific management and research in Ireland, England, the United States, France, Germany and Australia.
Melissa Helen Little is an Australian scientist and academic, currently Theme Director of Cell Biology, heading up the Kidney Regeneration laboratory at the Murdoch Children's Research Institute. She is also a Professor in the Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, and Program Leader of Stem Cells Australia. In January 2022, she became CEO of the Novo Nordisk Foundation Center for Stem Cell Medicine reNEW, an international stem cell research center based at University of Copenhagen, and a collaboration between the University of Copenhagen, Denmark, Murdoch Children’s Research Institute, Australia, and Leiden University Medical Center, The Netherlands.
Alan Frederick Cowman AC, FRS, FAA, CorrFRSE, FAAHMS, FASP, FASM is an internationally acclaimed malaria researcher whose work specialises in researching the malaria-causing parasite, Plasmodium falciparum, and the molecular mechanisms it uses to evade host responses and antimalarial drugs. As of May 2024, he is the deputy directory and Laboratory Head of the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, and his laboratory continues to work on understanding how Plasmodium falciparum, infects humans and causes disease. He was elected as a fellow of the Royal Society in 2011 and awarded the Companion of the Order of Australia in 2019 for his "eminent service to the biological sciences, notably to molecular parasitology, to medical research and scientific education, and as a mentor."
Anne Kelso is an Australian biomedical researcher specialising in immunology and influenza. She is the Chief Executive Officer of the Australian Government's National Health and Medical Research Council (NHMRC).
Sarah Elizabeth Medland is Professor and Psychiatric Genetics Group Leader at the QIMR Berghofer Medical Research Institute in Herston, Brisbane, Australia. She played a major role in the development of the ENIGMA brain imaging consortium.
Georgina Venetia Long is an Australian medical oncologist, clinical trialist and translational researcher, and works in drug therapy development. She was the joint recipient of the National Australia Day Council's 2024 Australian of the Year Award.
Emily Banks is an Australian epidemiologist and public health physician, working mainly on chronic disease. She is a Professor of Epidemiology and Public Health and Head of the Centre for Public Health Data and Policy at the Australian National University, and a visiting professor at the University of Oxford.
Fabienne Mackay is a French Australian research immunologist and institutional leader within the Australian medical research, education and innovation sectors. She is the Director and CEO of the QIMR Berghofer Medical Research Institute since 2020, after being the inaugural Head of the School of Biomedical Sciences at the University of Melbourne during the preceding five years. She is also an Honorary Professor at the Faculties of Medicine of the University of Queensland and the University of Melbourne. Her work has attracted public attention for its contribution to the pathophysiological understanding and treatment of lupus and other autoimmune diseases. Mackay has been notably awarded, achieving international reputation for her widely cited research describing B-cell activating factor (BAFF) and other cytokines of the TNF receptor superfamily, and their roles in B cell physiology, autoimmunity and cancer. She is an elected Fellow of the Australian Academy of Health and Medical Sciences.
Lyn Robyn Griffiths is an Australian academic who serves as Distinguished Professor of molecular genetics at Queensland University of Technology, where she is director of the Centre for Genomics and Personalised Health, the Genomics Research Centre and the BridgeTech Programs. Griffiths is internationally renowned for her work in the discovery of the genetics of migraine headaches.
Margaret Anne Tucker is an American oncologist and physician-scientist specialized in environmental and genetic epidemiology, familial cancers, and melanomas. She is a scientist emeritia at the National Cancer Institute (NCI). Tucker was a commissioned officer in the United States Public Health Service Commissioned Corps and served as director of the NCI human genetics program from 2005 until her retirement in June 2018.