Interstate 59 (I-59) is an Interstate Highway located in the southeastern United States. It is a north–south route that spans 445.23 miles (716.53 km) from a junction with I-10 and I-12 at Slidell, Louisiana, to a junction with I-24 near Wildwood, Georgia.
Interstate 65 (I-65) is a major north–south Interstate Highway in the central United States. As with most primary Interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12), and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
U.S. Route 72 (US 72) is an east–west United States highway that travels for 317.811 miles (511.467 km) from southwestern Tennessee, throughout North Mississippi, North Alabama, and southeastern Tennessee. The highway's western terminus is in Memphis, Tennessee and its eastern terminus is in Chattanooga. It is the only U.S. Highway to begin and end in the same state, yet pass through other states in between. Prior to the U.S. Highway system signage being posted in 1926, the entire route was part of the Lee Highway.
U.S. Route 231 (US 231) is a north–south U.S highway that is a parallel route of US 31. It runs for 912 miles (1,468 km) from St. John, Indiana, at US 41 to south of US 98 in downtown Panama City, Florida. One of its most notable landmarks is the William H. Natcher Bridge, a 0.853 miles (1.373 km) long cable-stayed bridge that connects Rockport, Indiana, to Owensboro, Kentucky, spanning the Ohio River.
Interstate 195 (I-195) is an auxiliary Interstate Highway in the US state of Virginia. Known as the Beltline Expressway, the highway runs 3.24 miles (5.21 km) from State Route 195 (SR 195), a toll road that continues south into Downtown Richmond, north to I-64 and I-95 on the northern edge of Richmond. I-195 passes through the West End of Richmond and connects I-64 and I-95 with US Route 33 (US 33) and US 250, which follow Broad Street, and with SR 76, a toll road that links Richmond with the Southside of the metropolitan area.
Interstate 110 (I-110) is a 6.341-mile (10.205 km) auxiliary route of the Interstate Highway System in Pensacola, Florida, extending north from U.S. Route 98 (US 98) to I-10. I-110 carries the hidden Florida Department of Transportation designation of State Road 8A. The easternmost auxiliary route of I-10, it is also known as the Reubin O'Donovan Askew Parkway in honor of the former governor of Florida who originated in Pensacola.
Interstate 565 (I-565) is a 22-mile-long (35 km) Interstate spur that connects I-65 in Decatur with U.S. Route 72 (US 72) in Huntsville in the US state of Alabama.
U.S. Route 431 (US 431), internally designated by the Alabama Department of Transportation (ALDOT) as State Route 1 (SR 1), is a major north–south state highway across the eastern part of the U.S. state of Alabama. Although US 431's south end is in Dothan, SR 1 continues south for about 13 miles (21 km) along US 231 to the Florida state line.
The Huntsville-Decatur-Albertville, AL Combined Statistical Area is the most populated sub-region of North Alabama, and is the second largest Combined Statistical Area in the State of Alabama after Birmingham. The Huntsville-Decatur-Albertville CSA had a total of 879,315 people in 2022 and ranks 68th in the country.
Alternate U.S. Route 72 exists in Alabama on the south side of the Tennessee River between Muscle Shoals and Decatur, while US 72 follows on the north side of the river between Florence and Athens. US 72 Alt. crosses the Tennessee River at Decatur, along with US 31, and follows the entire route of Interstate 565 (I-565). SR-20 was co-signed with US 72 Alt. from Muscle Shoals to Huntsville but has since been truncated to the junction of I-65 just east of Decatur.
State Route 20 (SR 20) is a 73.978-mile-long (119.056 km) state highway in the northern part of the U.S. state of Alabama. It travels from the Tennessee state line, where it continues as Tennessee State Route 69, northwest of Florence, east to Interstate 65 (I-65), east of Decatur. It crosses the Tennessee River at Florence and also at Decatur
Memorial Parkway, also known as the Parkway, is a major thoroughfare in Huntsville, Alabama that carries over 100,000 vehicles on average a day. It, in whole or in part, follows U.S. Route 231, U.S. Route 431, U.S. Route 72, and State Route 53 through the Huntsville city limits. It is a limited access road through most of Huntsville city proper, providing exits to the frontage road which allows access to road intersections, as well as businesses and residences along the route. Both the limited access and frontage roads are referred to as Memorial Parkway. Originally constructed to bypass downtown Huntsville and officially opened on December 1, 1955, the highway is the major commercial thoroughfare through Huntsville, a status it has held since the mid-1960s.
Interstate 85 (I-85) is a part of the Interstate Highway System that runs from Montgomery, Alabama, to Petersburg, Virginia. In Alabama, the Interstate Highway runs 80 miles (130 km) from I-65 in Montgomery northeast to the Georgia state line near Valley. Although it is nominally north–south as it carries an odd number, I-85 travels east–west through the state. It is the primary highway between Montgomery and Atlanta. The Interstate also connects Montgomery with Tuskegee, Auburn, Opelika, and, indirectly, Phenix City and Columbus, Georgia.
Interstate 65 (I-65) meanders across 366 miles (589 km) of the Alabama countryside linking six of the state's 10 largest cities. The highway links together many important roadways that make commerce inside and outside of the state's boundaries possible. It starts at I-10 near Mobile. The route passes through the major cities of Montgomery, Birmingham, Decatur, Huntsville, and Athens before entering Tennessee in the north near the town of Ardmore, Alabama.
State Route 35 (SR 35) is a 68.291-mile-long (109.904 km) state highway in the northeastern part of the U.S. state of Alabama. The southern terminus of the highway is at its intersection with SR 9 in rural Cherokee County northeast of Cedar Bluff and near the Georgia state line. The northern terminus of the highway is at Woodville in Jackson County where it has a second intersection with U.S. Route 72 (US 72).
U.S. Route 231 (US 231) in Alabama runs north–south up through the eastern half of Alabama for 306.273 miles (492.899 km). US 231 enters the state from Florida south of Madrid and exits into Tennessee, running councurrently with US 431 north of Hazel Green. US 231 passes through the major cities of Dothan, Troy, Montgomery, and Huntsville.
State Route 133 (SR 133) is a 16.976-mile-long (27.320 km) mostly multi-lane state highway and is a primary artery through the Florence–Muscle Shoals metropolitan area in the northwestern part of the U.S. state of Alabama.
Governors Drive is a major east–west thoroughfare in Huntsville, Alabama. It follows U.S. Route 431 (US-431) in east Huntsville and State Route 53 (SR-53) in west Huntsville. Governors Drive is one of the main entrance points to the city from the east, carrying on average approximately 48,000 vehicles a day across Monte Sano Mountain.
University Drive is a major east–west thoroughfare in Huntsville, Alabama, following US Route 72 into the city from the west. The highway carries on average approximately 56,000 vehicles a day at 45 mph (72 km/h).
Bob Wallace Avenue and Sparkman Drive are major thoroughfares in Huntsville, Alabama that connect to make a horseshoe-shaped road around the city. The two roads run through several residential neighborhoods and school zones including the University of Alabama in Huntsville. On average, approximately 21,000 vehicles travel along the roads each day.
I-565 / US 72 Alt. in Huntsville 
SR 53 in Huntsville
