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The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the betterment of all humanity. AAAS was the first permanent organization to promote science and engineering nationally and to represent the interests of American researchers from across all scientific fields. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal Science.
Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, around 20 carbon units in length. Eicosanoids are a sub-category of oxylipins, i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished from other oxylipins by their overwhelming importance as cell signaling molecules. Eicosanoids function in diverse physiological systems and pathological processes such as: mounting or inhibiting inflammation, allergy, fever and other immune responses; regulating the abortion of pregnancy and normal childbirth; contributing to the perception of pain; regulating cell growth; controlling blood pressure; and modulating the regional flow of blood to tissues. In performing these roles, eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to impact cells in the proximity of their cells of origin. Eicosanoids may also act as endocrine agents to control the function of distant cells.
Sir John Robert Vane was a British pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and blood vessel disease and introduction of ACE inhibitors. He was awarded the Nobel Prize in Physiology or Medicine in 1982 along with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances".
Earl Wilbur Sutherland Jr. was an American pharmacologist and biochemist born in Burlingame, Kansas. Sutherland won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers, namely cyclic adenosine monophosphate, or cyclic AMP.
Alfred Goodman Gilman was an American pharmacologist and biochemist. He and Martin Rodbell shared the 1994 Nobel Prize in Physiology or Medicine "for their discovery of G-proteins and the role of these proteins in signal transduction in cells."
Craig Jon Hawker is an Australian-born chemist. His research has focused on the interface between organic and polymer chemistry, with emphasis on the design, synthesis, and application of well-defined macromolecular structures in biotechnology, microelectronics, and surface science. Hawker holds more than 45 U.S. patents, and he has co-authored over 300 papers in the areas of nanotechnology, materials science, and chemistry. He was listed as one of the top 100 most cited chemists worldwide over the decade 1992–2002, and again in 2000–2010.
Sir Salvador Enrique Moncada Seidner, FRS, FRCP, FMedSci is a Honduran-British pharmacologist and professor. He is currently Research Domain Director for Cancer at the University of Manchester.
Sir John Henry Gaddum was an English pharmacologist who, along with Ulf von Euler, co-discovered the neuropeptide Substance P in 1931. He was a founder member of the British Pharmacological Society and first editor of the British Journal of Pharmacology.
Vanderbilt University School of Medicine is a graduate medical school of Vanderbilt University located in Nashville, Tennessee. Located in the Vanderbilt University Medical Center on the southeastern side of the Vanderbilt University campus, the School of Medicine claims several Nobel laureates in the field of medicine. Through the Vanderbilt Health Affiliated Network, VUSM is affiliated with over 60 hospitals and 5,000 clinicians across Tennessee and five neighboring states, managing more than 2 million patient visits each year. It is considered one of the largest academic medical centers in the United States and is the primary resource for specialty and primary care in hundreds of adult and pediatric specialties for patients throughout the Mid-South.
Epidermis-type lipoxygenase 3 is a member of the lipoxygenase family of enzymes; in humans, it is encoded by the ALOXE3 gene. This gene is located on chromosome 17 at position 13.1 where it forms a cluster with two other lipoxygenases, ALOX12B and ALOX15B. Among the human lipoxygenases, ALOXE3 is most closely related in amino acid sequence to ALOX12B. ALOXE3, ALOX12B, and ALOX15B are often classified as epidermal lipoxygenases, in distinction to the other three human lipoxygenases, because they were initially defined as being highly or even exclusively expressed and functioning in skin. The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases with mouse Aloxe3 being the ortholog to human ALOXE3, mouse Alox12b being the ortholog to human ALOX12B, and mouse Alox8 being the ortholog to human ALOX15B [supplied by OMIM]. ALOX12B and ALOXE3 in humans, Alox12b and Aloxe3 in mice, and comparable orthologs in other in other species are proposed to act sequentially in a multistep metabolic pathway that forms products that are structurally critical for creating and maintaining the skin's water barrier function.
CYP4F22 is a protein that in humans is encoded by the CYP4F22 gene.
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Ranjit Roy Chaudhury, was an Indian clinical pharmacologist, medical academic and health planner, who headed the National Committee for formulating the policy and guidelines on drugs and clinical trials in India. He was the chairman of the joint programme of World Health Organization and Government of India on Rational Use of Drugs in India. He was the founder president of the Delhi Medical Council and the president of the Delhi Society for Promotion of Rational Use of Drugs.
Bimal Kumar Bachhawat was an Indian neurochemist and glycobiologist, known for his discovery of HMG-CoA lyase, an intermediate in the mevalonate and ketogenesis pathway, and for the elucidation of the molecular cause of metachromatic leukodystrophy, a hereditary disease of the brain His studies on sugar-bearing liposomes led to its use as a carrier for in situ delivery of drugs and hormones to diseased organs and he pioneered the therapy of systemic fungal infections using liposomal formulations. He was a recipient of several awards including the Shanti Swarup Bhatnagar Award, the highest Indian honor in science and technology and an elected fellow of three major Indian science academies. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 1990, for his contributions to science.
Marion Sewer (1972-2016) was a pharmacologist and professor at the University of California, San Diego's Skaggs School of Pharmacy and Pharmaceutical Sciences known for her research on steroid hormone biogenesis and her commitment to increasing diversity in science. Much of her research centered around cytochrome P450, a family of enzymes involved in the conversion of cholesterol into steroid hormones. She died unexpectedly at the age of 43 from a pulmonary embolism on January 28, 2016, while traveling through the Detroit airport.
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Nancy J. Brown is an American physician-scientist. She is the Jean and David W. Wallace Dean and C.N.H. Long Professor of Internal Medicine at Yale University School of Medicine, having formerly served as the Hugh Jackson Morgan Professor of Medicine and Pharmacology, and Chair and Physician-in-Chief of the Department of Medicine at Vanderbilt University School of Medicine.
Alissa Margaret Weaver is an American oncologist. In 2017, she was promoted to the Cornelius Vanderbilt Endowed Chair of Cell and Developmental Biology and Pathology, Microbiology and Immunology at the Vanderbilt University School of Medicine.
W. Kimryn Rathmell is an American physician-scientist whose work focuses on the research and treatment of patients with kidney cancers. She is the Hugh Jackson Morgan Professor and Chair of the Department of Medicine at Vanderbilt University Medical Center (VUMC), and Physician-in-Chief for Vanderbilt University Adult Hospital and Clinics in Nashville, Tennessee.
Bettie Sue Siler Masters is an adjunct professor at Duke University known for her work on nitric oxide synthase and cytochrome P450 reductase. She was the 1992 recipient of the FASEB Excellence in Science Award, and has been elected as a member of the National Academy of Medicine and as a fellow of the American Association for the Advancement of Science.
References
- 1 2 "Vanderbilt celebrates 18 elected fellows of the AAAS". Vanderbilt University. 25 November 2013. Retrieved 29 October 2015.
- ↑ "A R Brash" (PDF). The Strathallian . Vol. 9, no. 3. Autumn 1970. p. 13. Archived from the original (PDF) on 17 November 2015. Retrieved 29 October 2015.
- 1 2 3 4 5 6 Brash, Alan R (September 2009). "Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes". Phytochemistry . 70 (13–14): 1522–1531. doi:10.1016/j.phytochem.2009.08.005. PMC 2783490 . PMID 19747698.
- ↑ Alan R. Brash author entry at OpenAlex
- ↑ "AAAS Members Elected as Fellows". Science . 342: 1064. 29 November 2013. doi: 10.1126/science.342.6162.1062 .
