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Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affects a person's ability to function and carry out everyday activities. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Consciousness is not affected. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater cognitive decline than what is caused by normal aging.
Cerebrovascular disease includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation. Arteries supplying oxygen and nutrients to the brain are often damaged or deformed in these disorders. The most common presentation of cerebrovascular disease is an ischemic stroke or mini-stroke and sometimes a hemorrhagic stroke. Hypertension is the most important contributing risk factor for stroke and cerebrovascular diseases as it can change the structure of blood vessels and result in atherosclerosis. Atherosclerosis narrows blood vessels in the brain, resulting in decreased cerebral perfusion. Other risk factors that contribute to stroke include smoking and diabetes. Narrowed cerebral arteries can lead to ischemic stroke, but continually elevated blood pressure can also cause tearing of vessels, leading to a hemorrhagic stroke.
Diseases of affluence, previously called diseases of rich people, is a term sometimes given to selected diseases and other health conditions which are commonly thought to be a result of increasing wealth in a society. Also referred to as the "Western disease" paradigm, these diseases are in contrast to so-called "diseases of poverty", which largely result from and contribute to human impoverishment. These diseases of affluence have vastly increased in prevalence since the end of World War II.
The Framingham Heart Study is a long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of participants. Prior to the study almost nothing was known about the epidemiology of hypertensive or arteriosclerotic cardiovascular disease. Much of the now-common knowledge concerning heart disease, such as the effects of diet, exercise, and common medications such as aspirin, is based on this longitudinal study. It is a project of the National Heart, Lung, and Blood Institute, in collaboration with Boston University. Various health professionals from the hospitals and universities of Greater Boston staff the project.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repeated trauma to the head. The encephalopathy symptoms can include behavioral problems, mood problems, and problems with thinking. The disease often gets worse over time and can result in dementia. It is unclear if the risk of suicide is altered.
Boston University School of Public Health (BUSPH) is one of the graduate schools of Boston University. Founded in 1976, the School offers master's- and doctoral-level programs in public health. It is located in the heart of Boston University's Medical Campus in the South End neighborhood of Boston, Massachusetts. The school has more than 8,900 alumni, 267 faculty, and 227 staff; its students hail from more than 43 countries, and its total research portfolio is worth more than $180 million. BUSPH is fully accredited by the Council on Education for Public Health and ranked 6th among Public Health Graduate Schools by U.S. News & World Report.
Sagittal abdominal diameter (SAD) is a measure of visceral obesity, the amount of fat in the gut region. SAD is the distance from the small of the back to the upper abdomen. SAD may be measured when standing or supine. SAD may be measured at any point from the narrowest point between the last rib and the iliac crests to the midpoint of the iliac crests.
The prevention of dementia involves reducing the number of risk factors for the development of dementia, and is a global health priority needing a global response. Initiatives include the establishment of the International Research Network on Dementia Prevention (IRNDP) which aims to link researchers in this field globally, and the establishment of the Global Dementia Observatory a web-based data knowledge and exchange platform, which will collate and disseminate key dementia data from members states. Although there is no cure for dementia, it is well established that modifiable risk factors influence both the likelihood of developing dementia and the age at which it is developed. Dementia can be prevented by reducing the risk factors for vascular disease such as diabetes, high blood pressure, obesity, smoking, physical inactivity and depression. A study concluded that more than a third of dementia cases are theoretically preventable. Among older adults both an unfavorable lifestyle and high genetic risk are independently associated with higher dementia risk. A favorable lifestyle is associated with a lower dementia risk, regardless of genetic risk. In 2020, a study identified 12 modifiable lifestyle factors, and the early treatment of acquired hearing loss was estimated as the most significant of these factors, potentially preventing up to 9% of dementia cases.
Type 3 diabetes is a proposed term to describe the interlinked association between type 1 and type 2 diabetes, and Alzheimer's disease. This term is used to look into potential triggers of Alzheimer's disease in people with diabetes.
Michael Lee Boehnke is an American geneticist. He is the Richard G. Cornell Distinguished University Professor of Biostatistics at the University of Michigan School of Public Health, where he also directs the Center for Statistical Genetics. His research focuses on the genetic dissection of complex traits; in a career spanning 25 years, he has developed methods for analysis of human pedigrees, examined the history of breast cancer in genetically at risk individuals, and contributed important discoveries on the genetics of type 2 diabetes and related traits, such as obesity and blood lipid levels.
Vladimir Hachinski is a Canadian clinical neuroscientist and researcher based at the Schulich School of Medicine and Dentistry at Western University. He is also a Senior Scientist at London's Robarts Research Institute. His research pertains in the greatest part to stroke and dementia, the interactions between them and their joint prevention. He and John W. Norris helped to establish the world's first successful stroke unit at Sunnybrook Hospital in Toronto, and, by extension, helped cement stroke units as the standard of care for stroke patients everywhere. He discovered that the control of the heart by the brain is asymmetric, the fight/flight (sympathetic) response being controlled by the right hemisphere and the rest and digest (parasympathetic) response being controlled by the left hemisphere and damage to one key component can lead to heart irregularities and sudden death. This discovery has added fundamental knowledge to how the brain controls the heart and blood pressure and lays the foundation for helping prevent sudden death.
Joel Salinas is an American-born Nicaraguan neurologist, writer, and researcher, who is currently an Assistant Professor of Neurology at Harvard Medical School. He practices general neurology, with subspecialty in behavioral neurology and neuropsychiatry, at the Massachusetts General Hospital in Boston, Massachusetts. He is also a clinician-scientist at the Harvard T.H. Chan School of Public Health and the Framingham Study at the Boston University School of Medicine.
Julia Louise Bienias is an American biostatistician known for her highly-cited publications on Alzheimer's disease.
Lauren Anne Wise is a Canadian-American epidemiologist and Professor in the Department of Epidemiology at Boston University School of Public Health.
Rebecca Gottesman is Senior Investigator and Stroke Branch Chief at the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH). Before joining NINDS, she was Professor of Neurology and Epidemiology at Johns Hopkins University. Gottesman completed a B.A. in Psychology at Columbia University (1995), an M.D. at Columbia University (2000), and a Ph.D. in Clinical Investigation at Johns Hopkins University (2007). She is a Fellow of the American Neurological Association (2012) and a Fellow of the American Heart Association (2015).
Fredrick DuBois Bowman is an American statistician who is the Dean of the School of Public Health at the University of Michigan. His research applies statistical analysis to brain imaging to better understand Alzheimer's disease, schizophrenia and Parkinson's disease. Bowman is a member of the National Academy of Medicine, Fellow of the American Association for the Advancement of Science, and Fellow of the American Statistical Association.
Lisa Marie Sullivan is a biostatistician associated with the Framingham Heart Study. She is a professor of biostatistics at Boston University, where she is associate dean for education in the School of Public Health and the former chair of the biostatistics department.
Lynda D. Lisabeth is an American epidemiologist who is Professor and Senior Associate Dean for Faculty Affairs in the School of Public Health at the University of Michigan. Her research considers the epidemiology of stroke in the United States, and she has worked with the National Institute of Neurological Disorders and Stroke on the advancement of stroke research.
The Women's Healthy Ageing Project (WHAP) is the longest ongoing medical research project examining the health of Australian women. Its landmark studies concern women's heart and brain health, a long-neglected area of specialised research.
Alzheimer's disease (AD) in African Americans is becoming a rising topic of interest in AD care, support, and scientific research, as African Americans are disproportionately affected by AD. Recent research on AD has shown that there are clear disparities in the disease among racial groups, with higher prevalence and incidence in African Americans than the overall average. Pathologies for Alzheimer’s also seem to manifest differently in African Americans, including with neuroinflammation markers, cognitive decline, and biomarkers. Although there are genetic risk factors for Alzheimer’s, these account for few cases in all racial groups.
References
- ↑ "Alexa Beiser | SPH". www.bu.edu.
- ↑ "Alexa Beiser | School of Medicine". www.bumc.bu.edu.
- ↑ "Alexa Beiser | SPH". www.bu.edu. Retrieved 2022-08-14.
- ↑ "Dementia Rates Leveling Off, Despite Aging Population | SPH". www.bu.edu.
- ↑ "Stress Associated with Impaired Memory, Lower Brain Volumes | SPH". www.bu.edu.
- ↑ "Physical Activity Improves Cognitive and Vascular Health in Older People with Diabetes | SPH". www.bu.edu.
- ↑ Stangl, Dalene K. (February 2009). "Review of Introductory Applied Biostatistics". The American Statistician. 63 (1): 96–97. JSTOR 27644107.
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