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John Machlin Buchanan was an American professor of biochemistry at the Massachusetts Institute of Technology. He arrived at MIT in 1953 and retired in 1988 after a distinguished career in which he was elected a fellow of the American Academy of Arts and Sciences and the National Academy of Sciences. He played a key role in the development of MIT's Department of Biology as a major force in biochemistry research and was himself a prominent researcher of purine biosynthesis. He died in 2007 at age 89.
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Kenichi Yokoyama is an enzymologist, chemical biologist, and natural product biochemist originally from Tokyo, Japan. He is an Associate Professor of Biochemistry at Duke University School of Medicine. In 2019, Yokoyama was awarded the Pfizer Award in Enzyme Chemistry from the American Chemical Society.
James Allen Wells is a Professor of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology at the University of California, San Francisco (UCSF) and a member of the National Academy of Sciences. He received his B.A. degrees in biochemistry and psychology from University of California, Berkeley in 1973 and a PhD in biochemistry from Washington State University with Ralph Yount, PhD in 1979. He completed his postdoctoral studies at Stanford University School of Medicine with George Stark in 1982. He is a pioneer in protein engineering, phage display, fragment-based lead discovery, cellular apoptosis, and the cell surface proteome.
References
- A. Zaks and A. M. Klibanov (1985). "Enzyme-catalyzed processes in organic solvents". PNAS . 82 (10): 3192–3196. Bibcode:1985PNAS...82.3192Z. doi: 10.1073/pnas.82.10.3192 . PMC 397741 . PMID 3858815.
- A. Zaks and A. M. Klibanov (1988). "Enzymatic catalysis in nonaqueous solvents". Journal of Biological Chemistry . 263 (7): 3194–3201. doi: 10.1016/S0021-9258(18)69054-4 . PMID 3277967.
- 1 2 Liu, H.; Kim, Y.; Mello, K.; Lovaasen, J.; Shah, A.; Rice, N.; Yim, J. H.; Pappas, D.; Klibanov, A. M. (2014). "Alexander M. Klibanov, PhD". Applied Biochemistry and Biotechnology. 172 (3). MIT: 1254–1264. doi:10.1007/s12010-013-0593-4. hdl: 1721.1/107156 . PMID 24158590. S2CID 207355690 . Retrieved 15 November 2020.
