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Anca-Ligia Grosu (born 1962) is a Romanian-German radiation oncologist and professor with a research focus on the development of personalized therapy in radiation oncology. She is chair of the Radiation Oncology Department at the University Medical Center Freiburg, Germany, [1] and member of the German National Academy of Sciences Leopoldina. [2]
Anca Grosu attended medical school at the Medico-Pharmaceutical Institute (IMF) in Cluj-Napoca (today Iuliu Hațieganu University of Medicine and Pharmacy). [3] She continued her medical specialist training at the Department of Neurology, Harlaching Hospital, Munich (Germany) and the Departments of Radiology / Neuroradiology and Radiation Oncology at Rechts der Isar Hospital, Technical University of Munich, obtaining her board certification in 2000 and her habilitation in 2003. [4] Her research activities resulted in major contributions to the implementation and advancement of high precision radiation techniques such as radiosurgery and stereotactic radiotherapy. Another important focus of Grosu's research is the integration of biological and functional imaging in radiotherapy planning and monitoring. Her work has pioneered developments in this area. [5]
In 2006 to 2007 she worked as a researcher at Harvard Medical School, Massachusetts General Hospital, Department of Radiation Oncology / Proton Therapy Center in Boston. Grosu was appointed as professor and chair of the Radiation Oncology Department at the University Medical Center Freiburg, Germany in 2007. [6] Her team earned international recognition with major clinical research studies [7] leading to improvements in the diagnosis and treatment of cancer. [8]
Grosu was Vice Dean at the University of Freiburg Faculty of Medicine from 2010 to 2013, [9] and member of the University of Freiburg Senate from 2014 to 2019. Since October 2020 she is a member of the Freiburg University Council. [10]
Grosu is an advisory board member of German Cancer Aid (Deutsche Krebshilfe). [11] She holds the position of adjunct professor at the Department of Radiation Oncology, Ohio State University.
Grosu's research on personalized radiotherapy aims at optimizing radiation therapy, its planning and monitoring, by means of biological imaging, especially positron emission tomography (PET) and multiparametric magnetic resonance imaging (mpMRI). The individual requirements of each patient are determined using biomarkers, bio-imaging and biological radiotherapy planning, resulting in a personalized concept of radiation therapy. [12] Further areas of research include: high precision radiation therapy (radiosurgery and stereotactic radiation therapy, interventional radiation oncology), combination of radiotherapy and immunotherapy, radiation therapy in elderly patients, quality of life (QoL) and radiation therapy, as well as digital data management in radiation oncology. [13]
Radiation therapy or radiotherapy is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. It is normally delivered by a linear particle accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body, and have not spread to other parts. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor. Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist.
External beam radiation therapy (EBRT) is a form of radiotherapy that utilizes a high-energy collimated beam of ionizing radiation, from a source outside the body, to target and kill cancer cells. A radiotherapy beam is composed of particles which travel in a consistent direction; each radiotherapy beam consists of one type of particle intended for use in treatment, though most beams contain some contamination by other particle types.
A radiation oncologist is a specialist physician who uses ionizing radiation in the treatment of cancer. Radiation oncology is one of the three primary specialties, the other two being surgical and medical oncology, involved in the treatment of cancer. Radiation can be given as a curative modality, either alone or in combination with surgery and/or chemotherapy. It may also be used palliatively, to relieve symptoms in patients with incurable cancers. A radiation oncologist may also use radiation to treat some benign diseases, including benign tumors. In some countries, radiotherapy and chemotherapy are controlled by a single oncologist who is a "clinical oncologist". Radiation oncologists work closely with other physicians such as surgical oncologists, interventional radiologists, internal medicine subspecialists, and medical oncologists, as well as medical physicists and technicians as part of the multi-disciplinary cancer team. Radiation oncologists undergo four years of oncology-specific training whereas oncologists who deliver chemotherapy have two years of additional training in cancer care during fellowship after internal medicine residency in the United States.
In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. The chief advantage of proton therapy over other types of external beam radiotherapy is that the dose of protons is deposited over a narrow range of depth; hence in minimal entry, exit, or scattered radiation dose to healthy nearby tissues.
Radiosurgery is surgery using radiation, that is, the destruction of precisely selected areas of tissue using ionizing radiation rather than excision with a blade. Like other forms of radiation therapy, it is usually used to treat cancer. Radiosurgery was originally defined by the Swedish neurosurgeon Lars Leksell as "a single high dose fraction of radiation, stereotactically directed to an intracranial region of interest".
Stereotactic surgery is a minimally invasive form of surgical intervention that makes use of a three-dimensional coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery (SRS), etc.
Varian Medical Systems is an American radiation oncology treatments and software maker based in Palo Alto, California. Their medical devices include linear accelerators (LINACs) and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, proton therapy, and brachytherapy. The company supplies software for managing cancer clinics, radiotherapy centers, and medical oncology practices. Varian Medical Systems employs more than 7,100 people at manufacturing sites in North America, Europe, and China and approximately 70 sites globally.
The Alfred Hospital, also known as The Alfred or Alfred Hospital, is a leading tertiary teaching hospital in Melbourne, Victoria. It is the second oldest hospital in Victoria, and the oldest Melbourne hospital still operating on its original site. The Alfred Hospital is one of two major adult trauma centres in Victoria, and houses the largest intensive care unit in Australia. In 2021 it was ranked as one of the world's best hospitals. It is located at the corner of Commercial and Punt Roads, Prahran, opposite Fawkner Park.
Elekta is a global Swedish company that develops and produces radiation therapy and radiosurgery-related equipment and clinical management for the treatment of cancer and brain disorders. Elekta has a global presence in more than 120 countries, with over 40 offices around the world and about 4,700 employees.
In radiotherapy, radiation treatment planning (RTP) is the process in which a team consisting of radiation oncologists, radiation therapist, medical physicists and medical dosimetrists plan the appropriate external beam radiotherapy or internal brachytherapy treatment technique for a patient with cancer.
Tomotherapy is a type of radiation therapy treatment machine. In tomotherapy a thin radiation beam is modulated as it rotates around the patient, while they are moved through the bore of the machine. The name comes from the use of a strip-shaped beam, so that only one “slice” of the target is exposed at any one time by the radiation. The external appearance of the system and movement of the radiation source and patient can be considered analogous to a CT scanner, which uses lower doses of radiation for imaging. Like a conventional machine used for X-ray external beam radiotherapy, a linear accelerator generates the radiation beam, but the external appearance of the machine, the patient positioning, and treatment delivery is different. Conventional linacs do not work on a slice-by-slice basis but typically have a large area beam which can also be resized and modulated.
The CyberKnife System is a radiation therapy device manufactured by Accuray Incorporated. The system is used to deliver radiosurgery for the treatment of benign tumors, malignant tumors and other medical conditions.
Maurice Lenz was a pioneer in the field of radiation therapy. Born in Kovno, Russian Empire, Lenz studied at New York University and Bellevue Medical College, and received his medical degree from Columbia University College of Physicians and Surgeons in 1913. He was a professor of radiation oncology at the Columbia University College of Physicians and Surgeons, a past president of the American Radium Society and held many other clinical and administrative roles throughout a long career in medicine.
Professor Minesh P. Mehta, MD, FASTRO, is an American radiation oncologist and physician-scientist of Indian origin, Ugandan birth, Zambian Schooling and American Training, who contributed to the field of oncology for more than two and half decades.
Christopher M. Nutting is a British Professor of Clinical Oncology and medical consultant, specializing in head and neck cancers, who has helped develop Intensity-Modulated Radiotherapy (IMRT), an advanced form of Radiation therapy.
Joaquín Gómez Mira is a scientist and physician specialized in radiation oncology. Born and raised in Spain, he completed his studies and developed his career in the United States, where he moved in 1967. He is a member of the American Society of Clinical Oncology, and a Fellow and appointed councilor of the American College of Radiology. His work, achievements and lectures in the field of radiation oncology are held in high regard.
Northern Westchester Hospital (NWH), now known as Northwell Health, is a not-for-profit, 245-bed, all-private-room facility in Mount Kisco, New York. Founded in 1916, it serves residents of Northern Westchester, Putnam County and southern Dutchess County, as well as parts of Fairfield County, Connecticut.
Four-dimensional computed tomography (4DCT) is a type of CT scanning which records multiple images over time. It allows playback of the scan as a video, so that physiological processes can be observed and internal movement can be tracked. The name is derived from the addition of time to traditional 3D computed tomography. Alternatively, the phase of a particular process, such as respiration, may be considered the fourth dimension.
Jay Steven Loeffler was an American physician at Massachusetts General Hospital where he served as Chair of the Department of Radiation Oncology since 2000. He was the Herman and Joan Suit Professor of Radiation Oncology and Professor of Neurosurgery at Harvard Medical School.
Shakardokht (Shakar) Jafari is a Medical Physicist and an award-winning innovator based at the Surrey Technology Centre. She developed an efficient and low cost method of measuring a medical dose of radiation.
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