Anne Hultgren

Last updated
Anne Hultgren
Nationality American
Alma mater Johns Hopkins University, Franklin and Marshall College
Scientific career
InstitutionsArnold and Mabel Beckman Foundation, United States Department of Homeland Security
Academic advisorsChristopher S. Chen, Daniel Reich

Anne Hultgren was the Branch Chief for research and development in the Chemical and Biological Defense Division of the Science and Technology Directorate of the United States Department of Homeland Security. [1] She worked in the department from 2005 to 2015. There she helped to develop and test the "Detect-to-Protect" biological detection program. As of February 2015 she became the executive director of the Arnold and Mabel Beckman Foundation. [2]

Contents

Education

Hultgren received a B.A. in Physics and Mathematics from Franklin and Marshall College in 1999. [1] She received her Masters of Arts (2002) and Ph.D. in physics (2005) from Johns Hopkins University, where she worked with Daniel Reich and Christopher S. Chen on Cellular manipulation and patterning using ferromagnetic nanowires. [3] [4]

Career

Hultgren joined the Department of Homeland Security in February 2005. She has worked as a technical advisor, program manager, and branch chief. Hultgren was in charge of technology development relating to chemical and biological defense capabilities. These included development of sensors, decontamination methods, and novel assay designs. Her job was to help to "prepare for, respond to, and recover from a possible domestic biological attack". [5]

In the "Detect-to-Protect" biological detection program, Hultgren helped to develop sensors capable of detecting air-borne biological materials, and field tested them in the Boston subway system. Field testing occurred in 2009 and in 2012. Hultgren sprayed dead Bacillus subtilis , a common, non-toxic, food-grade bacterium, in subway tunnels. Working with Massachusetts Bay Transportation Authority, the Massachusetts Department of Public Health, and local public health officials, scientists monitored the dispersion and detection of the bacterium at Davis, Harvard, and Porter stations. [5] [6] [7] [8] The team's goal was to improve the effectiveness of its sensors as a possible early warning system for biological threats. Rather than collecting air filters daily and taking them to a lab for examination, installed sensors continuously monitored air quality by measuring polymerase chain reaction. "Trigger" sensors were installed to establish the usual background levels of biological material, and "confirmers" were tripped when expected levels were exceeded. Thirty minutes after release, a "confirmer" at a station a mile away detected the airborne bacterium. The combination of on site "trigger" and "confirmer" sensors was intended to minimize the occurrence of false alarms, which were a source of complaints with earlier systems. [9] [10]

Hultgren was one of the invited speakers at the 2014 hearings in Washington, D.C., to review the BioWatch program and the effectiveness of PCR-based detection assays used by the United States Post Office. [11]

She was also the program manager in charge of assessing needs and operating procedures for the First Responder Biodetection Technology Report and survey, and developing the Biodetection Guide for First Responders mobile app, released January 8, 2015. Their goal is to ensure that first responders have the up-to-date information that they need. [12]

Related Research Articles

<span class="mw-page-title-main">Bioterrorism</span> Terrorism involving biological agents

Bioterrorism is terrorism involving the intentional release or dissemination of biological agents. These agents include bacteria, viruses, insects, fungi, and/or toxins, and may be in a naturally occurring or a human-modified form, in much the same way as in biological warfare. Further, modern agribusiness is vulnerable to anti-agricultural attacks by terrorists, and such attacks can seriously damage economy as well as consumer confidence. The latter destructive activity is called agrobioterrorism and is a subtype of agro-terrorism.

Lawrence Livermore National Laboratory (LLNL) is a federally funded research and development center in Livermore, California, United States. Originally established in 1952, the laboratory now is sponsored by the United States Department of Energy and administrated by Lawrence Livermore National Security, LLC.

Biodefense refers to measures to restore biosecurity to a group of organisms who are, or may be, subject to biological threats or infectious diseases. Biodefense is frequently discussed in the context of biowar or bioterrorism, and is generally considered a military or emergency response term.

<span class="mw-page-title-main">Tularemia</span> Infectious disease caused by the bacterium Francisella tularensis

Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella tularensis. Symptoms may include fever, skin ulcers, and enlarged lymph nodes. Occasionally, a form that results in pneumonia or a throat infection may occur.

A biosensor is an analytical device, used for the detection of a chemical substance, that combines a biological component with a physicochemical detector. The sensitive biological element, e.g. tissue, microorganisms, organelles, cell receptors, enzymes, antibodies, nucleic acids, etc., is a biologically derived material or biomimetic component that interacts with, binds with, or recognizes the analyte under study. The biologically sensitive elements can also be created by biological engineering. The transducer or the detector element, which transforms one signal into another one, works in a physicochemical way: optical, piezoelectric, electrochemical, electrochemiluminescence etc., resulting from the interaction of the analyte with the biological element, to easily measure and quantify. The biosensor reader device connects with the associated electronics or signal processors that are primarily responsible for the display of the results in a user-friendly way. This sometimes accounts for the most expensive part of the sensor device, however it is possible to generate a user friendly display that includes transducer and sensitive element. The readers are usually custom-designed and manufactured to suit the different working principles of biosensors.

An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity. The measured entity is often called the analyte, the measurand, or the target of the assay. The analyte can be a drug, biochemical substance, chemical element or compound, or cell in an organism or organic sample. An assay usually aims to measure an analyte's intensive property and express it in the relevant measurement unit.

<span class="mw-page-title-main">Biochip</span> Substrates performing biochemical reactions

In molecular biology, biochips are engineered substrates that can host large numbers of simultaneous biochemical reactions. One of the goals of biochip technology is to efficiently screen large numbers of biological analytes, with potential applications ranging from disease diagnosis to detection of bioterrorism agents. For example, digital microfluidic biochips are under investigation for applications in biomedical fields. In a digital microfluidic biochip, a group of (adjacent) cells in the microfluidic array can be configured to work as storage, functional operations, as well as for transporting fluid droplets dynamically.

<span class="mw-page-title-main">Immunoassay</span> Biochemical test for a protein or other molecule using an antibody

An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoassay is often referred to as an "analyte" and is in many cases a protein, although it may be other kinds of molecules, of different sizes and types, as long as the proper antibodies that have the required properties for the assay are developed. Analytes in biological liquids such as serum or urine are frequently measured using immunoassays for medical and research purposes.

The National Biodefense Analysis and Countermeasures Center (NBACC) is a government biodefense research laboratory created by the U.S. Department of Homeland Security (DHS) and located at the sprawling biodefense campus at Fort Detrick in Frederick, MD, USA. The NBACC is the principal U.S. biodefense research institution engaged in laboratory-based threat assessment and bioforensics. NBACC is an important part of the National Interagency Biodefense Campus (NIBC) also located at Fort Detrick for the US Army, National Institutes of Health and the US Department of Agriculture.

<span class="mw-page-title-main">Fido explosives detector</span>

The Fido explosives detector is a battery-powered, handheld sensory device that uses amplifying fluorescent polymer (AFP) materials to detect trace levels of high explosives like trinitrotoluene (TNT). It was developed by Nomadics, a subsidiary of ICX Technologies, in the early 2000s as part of the Defense Advanced Research Projects Agency's (DARPA) Dog's Nose program. The Fido explosives detector is considered the first artificial nose capable of detecting landmines in the real world. The device was named after its ability to detect explosive vapors at concentrations of parts per quadrillion, which is comparable to the sensitivity of a bomb-sniffing dog’s nose, i.e. the historical “gold standard” for finding concealed explosives.

<span class="mw-page-title-main">Autonomous detection system</span> Automated biohazard detection system

Autonomous Detection Systems (ADS), also called biohazard detection systems or autonomous pathogen detection systems, are designed to monitor air in an environment and to detect the presence of airborne chemicals, toxins, pathogens, or other biological agents capable of causing human illness or death. These systems monitor the air continuously and send real-time alerts to appropriate authorities in the event of an act of bioterrorism or biological warfare.

Materials MASINT is one of the six major disciplines generally accepted to make up the field of Measurement and Signature Intelligence (MASINT), with due regard that the MASINT subdisciplines may overlap, and MASINT, in turn, is complementary to more traditional intelligence collection and analysis disciplines such as SIGINT and IMINT. MASINT encompasses intelligence gathering activities that bring together disparate elements that do not fit within the definitions of Signals Intelligence (SIGINT), Imagery Intelligence (IMINT), or Human Intelligence (HUMINT).

BioWatch is a United States federal government program to detect the release of pathogens into the air as part of a terrorist attack on major American cities. Reportedly operating in Philadelphia, New York City, Washington, DC, San Diego, Boston, Chicago, San Francisco, Atlanta, St. Louis, Houston, Los Angeles and 21 other cities, the BioWatch program was created in 2001 in response to the increased threat of bioterrorism sparked by the 2001 anthrax attacks, and was announced in President George W. Bush's State of the Union Address of 2003.

<span class="mw-page-title-main">DHS Chemical and Biological Defense Division</span>

The Chemical and Biological Defense Division (CBD) is a division of the Science and Technology Directorate of the United States Department of Homeland Security. Within the Homeland Security Advanced Research Projects Agency, CBD develops technologies to increase the United States's preparedness and protect key national infrastructure against chemical, biological, and agricultural threats and disasters through improved threat awareness and advanced surveillance, detection, and protective countermeasures.

<span class="mw-page-title-main">Nucleic acid test</span> Group of techniques to detect a particular nucleic acid sequence

A nucleic acid test (NAT) is a technique used to detect a particular nucleic acid sequence and thus usually to detect and identify a particular species or subspecies of organism, often a virus or bacterium that acts as a pathogen in blood, tissue, urine, etc. NATs differ from other tests in that they detect genetic materials rather than antigens or antibodies. Detection of genetic materials allows an early diagnosis of a disease because the detection of antigens and/or antibodies requires time for them to start appearing in the bloodstream. Since the amount of a certain genetic material is usually very small, many NATs include a step that amplifies the genetic material—that is, makes many copies of it. Such NATs are called nucleic acid amplification tests (NAATs). There are several ways of amplification, including polymerase chain reaction (PCR), strand displacement assay (SDA), or transcription mediated assay (TMA).

<span class="mw-page-title-main">Future Attribute Screening Technology</span> Surveillance program

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<span class="mw-page-title-main">Molecular diagnostics</span> Collection of techniques used to analyze biological markers in the genome and proteome

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Brian T. Cunningham is an American engineer, researcher and academic. He is a Donald Biggar Willett Professor of Engineering at University of Illinois at Urbana-Champaign. He is a professor of Electrical and Computer Engineering, and a professor of Bioengineering.

References

  1. 1 2 "Dr. Anne Hultgren". Government Security Conference and Expo. Retrieved 15 April 2016.
  2. "$5 Million Gift Honors Theodore Brown and Arnold Beckman". Beckman Institute at the University of Illinois. September 8, 2015. Retrieved 15 April 2016.
  3. "Anne Hultgren, Ph.D." Chemistry Tree. Retrieved 15 April 2016.
  4. Felton, Edward J. (2009). Applications of Magnetic Nanostructures to Cell Patterning and Heterotypic Cell-cell Interactions. Baltimore, MD: Johns Hopkins University. p. 21. ISBN   978-1-109-13057-7.
  5. 1 2 "Boston Subway System to be Used to Test New Sensors for Biological Agents". Science and Technology. Homeland Security. 2012. Retrieved 15 April 2016.
  6. Massachusetts Bay Transportation Authority (September 7, 2012). "Menon Biodetector used in MBTA/DHS Testing". Menon Biosensors, Inc. Archived from the original on 25 April 2016. Retrieved 16 April 2016.
  7. Grant, Bob (August 29, 2012). "Boston to Test Bioterror Sensors". The Scientist. Retrieved 16 April 2016.
  8. Andersen, Travis (May 17, 2012). "Dead bacteria to be used to test T sensors". Boston Globe. Retrieved 16 April 2016.
  9. Hodson, Hal (September 12, 2012). "Detecting a subway bioterror attack". New Scientist. Retrieved 16 April 2016.
  10. Hodson, Hal (September 15, 2012). "Trouble underground". New Scientist. Archived from the original on April 24, 2016. Retrieved 16 April 2016.
  11. Committee on PCR Standards for the BioWatch Program (2015). BioWatch PCR Assays: Building Confidence, Ensuring Reliability. Washington, D.C.: National Academies Press. p. 160. ISBN   978-0-309-36722-6 . Retrieved 16 April 2016.
  12. "Understanding portable biodetection technology for identifying suspicious substances". Science Daily (Press release). January 29, 2015. Retrieved 16 April 2016.