Anneke Brand

Last updated
Anneke Brand
Born(1946-06-07)7 June 1946
The Hague, Netherlands
Died2021(2021-00-00) (aged 74–75)
Scientific career
FieldsMedicine, Transfusion Medicine, Hematology

Anneke Brand (1946-2021) was a Dutch physician-scientist whose work on platelet and red blood cell transfusion and cord blood transplantation earned her transfusion medicine's three highest honors: the AABB Karl Landsteiner Memorial Award; International Society of Blood Transfusion Presidential Award; and the British Blood Transfusion Society James Blundell Award.

Contents

Early life and education

Brand was born on 7 June 1946 in The Hague, the Netherlands. In 1973, she obtained her medical degree from the Free University Amsterdam. Brand earned her Ph.D. in 1978 from the Leiden Academic Hospital under Professors Jon van Rood [1] and George Eernisse, on the topic of 'Platelet Supportive Care'. Brand trained in internal medicine in Haarlem and in haematology at the Leiden Academic Hospital. [2]

Career

Brand studied the management of platelet refractoriness [3] and the role of leukocytes [4] [5] in erythrocyte alloimmunization [6] [7] [8] and transfusion outcomes. She helped establish the need for leukoreduction to diminish transfusion reactions. [9] [10] She studied the optimal conditions for the storage and expansion of cord blood [11] for transplantation, along with platelets [12] and red cells [13] [14] for transfusion.

Brand developed peri-operative blood management strategies [15] [16] and co-directed clinical platelet transfusion trials. [17] [18] [19] [20] She studied non-inherited maternal antigens [21] [22] [23] and factors that influence erythrocyte alloimmunization. [24] [25] She was the senior author on the MATCH study, which looked at whether red cell units should be matched only for ABO and RhD, or for additional erythrocyte antigens such as c, C, E, K, Fy(a), Jk(a), and S. [26]

Brand co-authored over 350 papers, helped found the Dutch Cord Blood Bank, [2] served on the board of the European Hematology Association from 2011 to 2015, [27] and helped develop educational programs for training physicians and laboratory technologists. [28] [29]

Awards

References

  1. ↑ Jager, Martine J.; Brand, Anneke; Claas, Frans H. J. (2019). "Jon van Rood: The pioneer and his personal view on the early developments of HLA and immunogenetics". Transplant Immunology. 52: 1–26. doi: 10.1016/j.trim.2018.12.006 . ISSN   1878-5492. PMID   30611771.
  2. 1 2 Kerkhoffs, Jean-Louis H.; So-Osman, Cynthia (2022). "Anneke Brand (1946–2021)". Vox Sanguinis. 117 (1): 149–150. doi: 10.1111/vox.13231 . ISSN   0042-9007. PMID   34918352.
  3. ↑ Kerkhoffs, Jean-Louis H.; Eikenboom, Jeroen C. J.; van de Watering, Leo M. G.; van Wordragen-Vlaswinkel, Rinie J.; Wijermans, Pierre W.; Brand, Anneke (2008). "The clinical impact of platelet refractoriness: correlation with bleeding and survival". Transfusion. 48 (9): 1959–1965. doi:10.1111/j.1537-2995.2008.01799.x. ISSN   1537-2995. PMID   18564396.
  4. ↑ Bilgin, Yavuz M.; van de Watering, Leo M. G.; Versteegh, Michel I. M.; van Oers, Marinus H. J.; Brand, Anneke (2010). "Effects of allogeneic leukocytes in blood transfusions during cardiac surgery on inflammatory mediators and postoperative complications". Critical Care Medicine. 38 (2): 546–552. doi:10.1097/CCM.0b013e3181c0de7b. ISSN   1530-0293. PMID   19864941.
  5. ↑ Schonewille, Henk; Brand, Anneke (2005). "Alloimmunization to red blood cell antigens after universal leucodepletion. A regional multicentre retrospective study". British Journal of Haematology. 129 (1): 151–156. doi:10.1111/j.1365-2141.2005.05408.x. ISSN   0007-1048. PMID   15801967.
  6. ↑ Natukunda, Bernard; Schonewille, Henk; Ndugwa, Christopher; Brand, Anneke (2010). "Red blood cell alloimmunization in sickle cell disease patients in Uganda". Transfusion. 50 (1): 20–25. doi:10.1111/j.1537-2995.2009.02435.x. ISSN   1537-2995. PMID   19821949.
  7. ↑ Schonewille, Henk; de Vries, Rene R. P.; Brand, Anneke (2009). "Alloimmune response after additional red blood cell antigen challenge in immunized hematooncology patients". Transfusion. 49 (3): 453–457. doi:10.1111/j.1537-2995.2008.01980.x. ISSN   1537-2995. PMID   19243541.
  8. ↑ Schonewille, Henk; van de Watering, Leo M. G.; Loomans, Dominique S. E.; Brand, Anneke (2006). "Red blood cell alloantibodies after transfusion: factors influencing incidence and specificity". Transfusion. 46 (2): 250–256. doi:10.1111/j.1537-2995.2006.00708.x. ISSN   0041-1132. PMID   16441603.
  9. ↑ van de Watering, Leo; Hermans, Jo; Witvliet, Marian; Versteegh, Michel; Brand, Anneke (2003). "HLA and RBC immunization after filtered and buffy coat-depleted blood transfusion in cardiac surgery: a randomized controlled trial". Transfusion. 43 (6): 765–771. doi:10.1046/j.1537-2995.2003.00390.x. ISSN   0041-1132. PMID   12757528.
  10. ↑ Brand, Anneke (2002). "Immunological aspects of blood transfusions". Transplant Immunology. 10 (2–3): 183–190. doi:10.1016/s0966-3274(02)00064-3. ISSN   0966-3274. PMID   12216948.
  11. ↑ Brand, Anneke; Eichler, Hermann; Szczepiorkowski, Zbigniew M.; Hess (2008). "Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise". Transfusion. 48 (3): 546–549. doi:10.1111/j.1537-2995.2007.01568.x. ISSN   0041-1132. PMID   18067495.
  12. ↑ Kerkhoffs, Jean-Louis H.; Eikenboom, Jeroen C.; Schipperus, Martin S. (2006-11-01). "A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma". Blood. 108 (9): 3210–3215. doi: 10.1182/blood-2006-04-020131 . ISSN   0006-4971. PMID   16825492.
  13. ↑ van de Watering, Leo M. G.; Brand, Anneke (2008). "Effects of storage of red cells". Transfusion Medicine and Hemotherapy. 35 (5): 359–367. doi: 10.1159/000155221 . ISSN   1660-3796. PMC   3076328 . PMID   21512625.
  14. ↑ van de Watering, Leo; Lorinser, Jos; Versteegh, Michel; Westendord, Rudi; Brand, Anneke (2006). "Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients". Transfusion. 46 (10): 1712–1718. doi:10.1111/j.1537-2995.2006.00958.x. ISSN   0041-1132. PMID   17002627.
  15. ↑ So-Osman, Cynthia; Nelissen, Rob G. H. H.; Koopman-van Gemert, Ankie W. M. M. (2014). "Patient blood management in elective total hip- and knee-replacement surgery (part 2): a randomized controlled trial on blood salvage as transfusion alternative using a restrictive transfusion policy in patients with a preoperative hemoglobin above 13 g/dl". Anesthesiology. 120 (4): 852–860. doi:10.1097/ALN.0000000000000135. ISSN   1528-1175. PMID   24434302.
  16. ↑ So-Osman, Cynthia; Nelissen, Rob G. H. H.; Koopman-van Gemert, Ankie W. M. M. (2014). "Patient blood management in elective total hip- and knee-replacement surgery (Part 1): a randomized controlled trial on erythropoietin and blood salvage as transfusion alternatives using a restrictive transfusion policy in erythropoietin-eligible patients". Anesthesiology. 120 (4): 839–851. doi: 10.1097/ALN.0000000000000134 . ISSN   1528-1175. PMID   24424070.
  17. ↑ Saris, Anno; Tomson, Bert; Brand, Anneke; Mulder, Arend (2018-01-04). "Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization". Blood. 131 (1): 144–152. doi: 10.1182/blood-2017-07-799270 . ISSN   1528-0020. PMID   29092829.
  18. ↑ van Hout, Fabienne M. A.; Hogervorst, Esther K.; Rosseel, Peter M. J.; van der Bom, Johanna G. (2017). "Does a Platelet Transfusion Independently Affect Bleeding and Adverse Outcomes in Cardiac Surgery?". Anesthesiology. 126 (3): 441–449. doi:10.1097/ALN.0000000000001518. ISSN   1528-1175. PMID   28092320.
  19. ↑ Baharoglu, M. Irem; Cordonnier, Charlotte; Al-Shahi Salman, Rustam; de Gans, Koen; Koopman, Maria M.; Brand, Anneke (2016-06-25). "Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial". Lancet. 387 (10038): 2605–2613. doi: 10.1016/S0140-6736(16)30392-0 . hdl: 20.500.11820/caca8ad3-3c23-4622-85b9-094a197661b5 . ISSN   1474-547X. PMID   27178479.
  20. ↑ Ypma, Paula F.; van der Meer, Pieter F.; Heddle, Nancy M.; van Hilten, Joost A.; Stijnen, Theo; Middelburg, Rutger A.; Hervig, Tor; van der Bom, Johanna G.; Brand, Anneke; Kerkhoffs, Jean-Louis H.; PREPAReS Study Group (2016-01-27). "A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial". BMJ Open. 6 (1) e010156. doi: 10.1136/bmjopen-2015-010156 . ISSN   2044-6055. PMC   4735127 . PMID   26817642.
  21. ↑ Schonewille, Henk; van de Watering, Leo M. G.; Oepkes, Dick; Lopriore, Enrico; Cobbaert, Christa M.; Brand, Anneke (2020). "Prevalence of red-blood-cell and non-red-blood-cell-targeted autoantibodies in alloimmunized postpartum women". Vox Sanguinis. 115 (8): 783–789. doi: 10.1111/vox.12941 . hdl: 1887/3181244 . ISSN   1423-0410. PMID   32458481.
  22. ↑ Schonewille, Henk; van Rood, Jon J.; Verduin, Esther P.; van de Watering, Leo M. G. (2019). "Exposure to non-inherited maternal antigens by breastfeeding affects antibody responsiveness". Haematologica. 104 (2): 263–268. doi: 10.3324/haematol.2018.199406 . ISSN   1592-8721. PMC   6355501 . PMID   30213833.
  23. ↑ Van der Zanden, Henk G. M.; Van Rood, Jon J.; Oudshoorn, Machteld; Bakker, Jack N. A.; Melis, Angelo; Brand, Anneke; Scaradavou, Andromachi; Rubinstein, Pablo (2014). "Noninherited maternal antigens identify acceptable HLA mismatches: benefit to patients and cost-effectiveness for cord blood banks". Biology of Blood and Marrow Transplantation. 20 (11): 1791–1795. doi: 10.1016/j.bbmt.2014.07.011 . ISSN   1523-6536. PMID   25042738.
  24. ↑ Brand, Anneke (2016). "Immunological complications of blood transfusions". Presse Médicale. 45 (7-8 Pt 2): e313–324. doi:10.1016/j.lpm.2016.06.024. ISSN   2213-0276. PMID   27499223.
  25. ↑ Verduin, Esther P.; Brand, Anneke; Middelburg, Rutger A.; Schonewille, Henk (2015). "Female sex of older patients is an independent risk factor for red blood cell alloimmunization after transfusion". Transfusion. 55 (6 Pt 2): 1478–1485. doi:10.1111/trf.13111. ISSN   1537-2995. PMID   25846865.
  26. ↑ Schonewille, Henk; Honohan, Áine; van der Watering, Leo M. G.; Hudig, Francisca; Te Boekhorst, Peter A.; Koopman-van Gemert, Ankie W. M. M.; Brand, Anneke (2016). "Incidence of alloantibody formation after ABO-D or extended matched red blood cell transfusions: a randomized trial (MATCH study)". Transfusion. 56 (2): 311–320. doi:10.1111/trf.13347. ISSN   1537-2995. PMID   26442648.
  27. ↑ "In Memoriam Anneke Brand". The European Hematology Association (EHA). 2021-11-21. Retrieved 2024-11-10.
  28. ↑ Garraud, Olivier; Brand, Anneke; Henschler, Reinhard; Vuk, Tomislav (2018). "Medical student education in transfusion medicine: Proposal from the "European and Mediterranean initiative in transfusion medicine"". Transfusion and Apheresis Science. 57 (5): 593–597. doi:10.1016/j.transci.2018.09.002. ISSN   1473-0502. PMID   30274948.
  29. ↑ Garraud, Olivier; Vuk, Tomislav; Brand, Anneke; de Angelis, Vincenzo (2020). "Medical student education in transfusion medicine, part II: Moving forward to building up a "Know How" education program in transfusion medicine for under-graduate medical students". Transfusion and Apheresis Science. 59 (6) 102879. doi: 10.1016/j.transci.2020.102879 . ISSN   1473-0502. PMID   32718832.
  30. ↑ "Past winners". BBTS. 2011-06-16. Retrieved 2024-11-10.
  31. ↑ "Presidential Award Session: Anneke Brand". The International Society of Blood Transfusion (ISBT). 2020-12-14. Retrieved 2024-11-10.
  32. ↑ "AABB Congratulates 2021 AABB Award Recipients". www.aabb.org. 2021-09-20. Retrieved 2024-11-10.
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