Anthony Hollander

Last updated

Anthony Hollander (born 4 February 1964) has worked at the University of Liverpool since June 2014, starting out as the Head of the Institute of Integrative Biology, he was then appointed as the Pro-Vice-Chancellor for Research & Impact in August 2017. A post he still occupies as well as being the Professor of Stem Cell Biology at the university and the Chair of the N8 Research Partnership Strategic Executive Group.

Contents

Career

In 2009, Biddy Baxter, the editor of the children's television programme Blue Peter published a selection of children's letters received by the Blue Peter team. Amongst them was a letter from Hollander who had written in 1973 that he knew how to save lives. Having gone on to pioneer stem cell therapies for diseases of the cartilage, he now says that he owes his career to Miss Baxter: "If her letter had shown any hint of ridicule or disbelief I might perhaps never have trained to become a medical scientist or been driven to achieve the impossible dream, and really make a difference to a human being's life." [1]

Hollander grew up in North West London, one of six children. He was a pupil at Christ's College Finchley and from there went to The University of Bath where he read for a degree in Pharmacology and graduated with First Class Honours in 1987. He then moved to The University of Bristol where he undertook his doctoral research in the field of cartilage degradation in arthritis. He was awarded his PhD in 1990. [2] He then moved to Montreal, Canada where he was a postdoctoral scientist at McGill University for three years, again studying cartilage degradation in arthritis. In 1993 he was awarded a three-year Fellowship from The Arthritis Research Campaign (now Arthritis Research UK) [3] to be based in The University of Sheffield where he was appointed as lecturer. He was promoted to Reader in 1999 and he was then appointed to his chair at The University of Bristol in 2000. In 2010, The Times newspaper ranking of Britain's 100 most important scientists included him at number 39 on the list. He was elected as President of The International Cartilage Repair Society for the term of office May 2012 until September 2013.

He is co-founder, Director and Chief Scientific Officer of Azellon Cell Therapeutics, [4] a University of Bristol spin-out company funded to undertake the first clinical trial of stem cells for the treatment of torn knee cartilage. The trial was completed on 5 patients who had sustained white-zoned meniscal tears and the results were published in 2016. [5]

He was appointed the Head of the Institute of Integrative Biology [6] at the University of Liverpool in June 2014. The Institute lies at the heart of a thriving bio-medical-science campus in Liverpool and has integrated bioscience structures with internationally recognized expertise ranging from electrons to ecosystems. Its science serves several key societal themes including food security, health and welfare, diagnostics, biodiversity and conservation and biofuels.

Related Research Articles

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is one of the institutes and centers that make up the National Institutes of Health, an agency of the United States Department of Health and Human Services (HHS).

<span class="mw-page-title-main">Medical Research Council (United Kingdom)</span> National medical research agency

The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy.

<span class="mw-page-title-main">WEHI</span> Medical research institute in Victoria, Australia

WEHI, previously known as the Walter and Eliza Hall Institute of Medical Research, and as the Walter and Eliza Hall Institute, is Australia's oldest medical research institute. Sir Frank Macfarlane Burnet, who won the Nobel Prize in 1960 for his work in immunology, was director from 1944 to 1965. Burnet developed the ideas of clonal selection and acquired immune tolerance. Later, Professor Donald Metcalf discovered and characterised colony-stimulating factors. As of 2015, the institute hosted more than 750 researchers who work to understand, prevent and treat diseases including blood, breast and ovarian cancers; inflammatory diseases (autoimmunity) such as rheumatoid arthritis, type 1 diabetes and coeliac disease; and infectious diseases such as malaria, HIV and hepatitis B and C.

<span class="mw-page-title-main">Synovial fluid</span> Fluid found in the cavities of synovial joints

Synovial fluid, also called synovia,[help 1] is a viscous, non-Newtonian fluid found in the cavities of synovial joints. With its egg white–like consistency, the principal role of synovial fluid is to reduce friction between the articular cartilage of synovial joints during movement. Synovial fluid is a small component of the transcellular fluid component of extracellular fluid.

<span class="mw-page-title-main">Paul Nurse</span> English geneticist and Nobel laureate

Sir Paul Maxime Nurse is an English geneticist, former President of the Royal Society and Chief Executive and Director of the Francis Crick Institute. He was awarded the 2001 Nobel Prize in Physiology or Medicine along with Leland Hartwell and Tim Hunt for their discoveries of protein molecules that control the division of cells in the cell cycle.

The Kolling Institute is located in the grounds of the Royal North Shore Hospital in St Leonards, Sydney Australia. The institute, founded in 1920, is the oldest medical research institute in New South Wales.

<span class="mw-page-title-main">Cambridge Biomedical Campus</span>

The Cambridge Biomedical Campus is the largest centre of medical research and health science in Europe. The site is located at the southern end of Hills Road in Cambridge, England.

The Australian Regenerative Medicine Institute (ARMI) is an Australian medical research institute. Opened in April 2009, the institute is based at the Clayton campus of Monash University, in the Monash Science Technology Research and Innovation Precinct.

Brigid L. M. Hogan FRS is a developmental biologist noted for her contributions to mammalian development, stem cell research and transgenic technology and techniques. She is currently a Professor in the Department of Cell Biology at Duke University, Born in the UK, she became an American citizen in 2000.

<span class="mw-page-title-main">Janet Rossant</span> Biologist

Janet Rossant, is a developmental biologist well known for her contributions to the understanding of the role of genes in embryo development. She is a world renowned leader in developmental biology. Her current research interests focus on stem cells, molecular genetics, and developmental biology. Specifically, she uses cellular and genetic manipulation techniques to study how genes control both normal and abnormal development of early mouse embryos. Rossant has discovered information on embryo development, how multiple types of stem cells are established, and the mechanisms by which genes control development. In 1998, her work helped lead to the discovery of the trophoblast stem cell, which has assisted in showing how congenital anomalies in the heart, blood vessels, and placenta can occur.

Frances Rosemary Balkwill is an English scientist, Professor of Cancer Biology at Queen Mary University of London, and author of children's books about scientific topics.

<span class="mw-page-title-main">Hans Clevers</span> Dutch molecular genetics and stem cell researcher

Johannes (Hans) Carolus Clevers is a Dutch molecular geneticist, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Swiss healthcare company Roche in 2022. Previously, he headed a research group at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center; he remained as an advisor and guest scientist or visiting researcher to both groups. He is also a Professor in Molecular Genetics at the University of Utrecht.

Amanda Jane Fosang is a biomedical researcher who has pioneered arthritis research in Australia.

Lorenz Studer is a Swiss biologist. He is the founder and director of the Center for Stem Cell Biology at Memorial-Sloan Kettering Cancer Center in New York City. He is a developmental biologist and neuroscientist who is pioneering the generation of midbrain dopamine neurons for transplantation and clinical applications. His expertise in cell engineering spans a wide range of cells/tissues within the nervous system geared toward disease modeling and exploring cell replacement therapy. Currently, he is a member of the Developmental Biology Program and Department of Neurosurgery at Memorial Sloan-Kettering Cancer Center and a Professor of Neuroscience at Weill Cornell Medical College in New York City, NY.

<span class="mw-page-title-main">Rocky Tuan</span> Hong Kong medical researcher and bioengineer

Rocky Tuan Sung-chi is a Hong Kong medical researcher and bioengineer, currently the vice-chancellor and president of the Chinese University of Hong Kong, where he served as distinguished visiting professor and director of the Institute for Tissue Engineering and Regenerative Medicine prior to taking up the vice-chancellorship. Previously he was on the faculty at the University of Pittsburgh, where he held a number of roles: Arthur J. Rooney Sr. Professor of Sports Medicine and the executive vice chair of the department of Orthopaedic Surgery, and a professor in the department of bioengineering. He was the director of the Center for Military Medicine Research and an associate director of the McGowan Institute for Regenerative Medicine. Despite his position in Hong Kong, he continues to serve as the director of the University of Pittsburgh's Center for Cellular and Molecular Engineering. For the 2018 fiscal year, he was one of the top 25 highest-paid University of Pittsburgh employees.

Mohan Ramachandra Wani is an Indian cell biologist, immunologist and a scientist at the National Centre for Cell Science. Known for his studies in the fields of bone and cartilage cell biology, osteoimmunology, and regenerative medicine, Wani is an elected fellow of the National Academy of Sciences, India and an elected member of Guha Research Conference. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences in 2009.

Artificial cartilage is a synthetic material made of hydrogels or polymers that aims to mimic the functional properties of natural cartilage in the human body. Tissue engineering principles are used in order to create a non-degradable and biocompatible material that can replace cartilage. While creating a useful synthetic cartilage material, certain challenges need to be overcome. First, cartilage is an avascular structure in the body and therefore does not repair itself. This creates issues in regeneration of the tissue. Synthetic cartilage also needs to be stably attached to its underlying surface i.e. the bone. Lastly, in the case of creating synthetic cartilage to be used in joint spaces, high mechanical strength under compression needs to be an intrinsic property of the material.

<span class="mw-page-title-main">Pamela Robey</span> American cell biologist

Pamela Gehron Robey is an American cell biologist. She is a senior investigator in the skeletal biology section at the National Institute of Dental and Craniofacial Research.

<span class="mw-page-title-main">Mohamadreza Baghaban Eslaminejad</span>

Mohamadreza Baghaban Eslaminejad is the director of the Adult Stem Cell Lab and histology/embryology Professor at the Royan Institute where he held a multi-departmental professorship in bioengineering, tissue engineering, regenerative medicine, and stem cell therapy. Eslaminejad studies have been cited over 4000 times. He is best known for Hard Tissue Engineering and utilizing Mesenchymal stem cells for treatment of orthopedic diseases.

Farshid Guilak is an American engineer and orthopedic researcher. He is the Mildred B. Simon Professor of Orthopaedic Surgery at Washington University in St. Louis and director of research at Shriners Hospitals for Children. He is also on the faculty of the departments of Biomedical Engineering, Mechanical Engineering & Materials Science, and Developmental Biology at Washington University.

References

  1. "Dear Blue Peter... I can save lives". BBC. 27 January 2009.
  2. Inflammation and joint damage in rhuematoid arthritis (1990). University of Bristol PhD thesis
  3. "Arthritis Research UK | Arthritis Research UK". Archived from the original on 15 July 2019. Retrieved 24 June 2022.
  4. "Home". azellonctx.com.
  5. Trial paper zellonctx.com [ dead link ]
  6. "Institute of Integrative Biology - Institute of Integrative Biology - University of Liverpool". Archived from the original on 10 August 2014. Retrieved 26 August 2014.