Antisialagogue

Last updated July 18, 2025

Antisialagogues are drugs or substances that decrease the flow rate of saliva and their effect is opposite to that of sialagogues.^[1] Their origin may be both natural and synthetic.

Anticholinergics generally have antisialagogue effects, and most produce some level of sedation, both being advantageous in surgical procedures.^[2]

Classic antisialagogues^[1] include:

atropine,
opioids,
alkalis,
hyoscyamine,
scopolamine,
tobacco in excess,
most cannabinoids,^[3]
all nauseous or insipid substances.

References

1 2 Dock LL (1916). "Drugs Acting On The Salivary Glands". Text-Book Of Materia Medica For Nurses. G. P. Putnam's Sons. Retrieved 15 October 2010.
↑ Hata TM, Moyers JR (2009). "Preoperative Patient Assessment and Management". In Cahalan MD, Barash PG, Cullen BF, Stoelting RK (eds.). Clinical Anesthesia. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 592. ISBN 978-0-7817-8763-5.
↑ Prestifilippo, Juan Pablo; Fernández-Solari, Javier; de la Cal, Carolina; Iribarne, María; Suburo, Angela M.; Rettori, Valeria; McCann, Samuel M.; Elverdin, Juan Carlos (September 2006). "Inhibition of salivary secretion by activation of cannabinoid receptors". Experimental Biology and Medicine. 231 (8): 1421–1429. doi:10.1177/153537020623100816. PMID 16946411.

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[MateriaMedicafN-1] 1 2 Dock LL (1916). "Drugs Acting On The Salivary Glands". Text-Book Of Materia Medica For Nurses. G. P. Putnam's Sons. Retrieved 15 October 2010.

[2] Hata TM, Moyers JR (2009). "Preoperative Patient Assessment and Management". In Cahalan MD, Barash PG, Cullen BF, Stoelting RK (eds.). Clinical Anesthesia. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 592. ISBN 978-0-7817-8763-5.

[3] Prestifilippo, Juan Pablo; Fernández-Solari, Javier; de la Cal, Carolina; Iribarne, María; Suburo, Angela M.; Rettori, Valeria; McCann, Samuel M.; Elverdin, Juan Carlos (September 2006). "Inhibition of salivary secretion by activation of cannabinoid receptors". Experimental Biology and Medicine. 231 (8): 1421–1429. doi:10.1177/153537020623100816. PMID 16946411.

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