Astrid Fagraeus | |
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| Born | May 30, 1913 |
| Died | February 24, 1997 |
| Nationality | Swedish |
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| Discipline | Immunologist |
| Notable works | Antibody Production in relation to the Development of Plasma Cells |
Astrid Elsa Fagraeus-Wallbom, born May 30, 1913, in Stockholm, Sweden and died February 24, 1997, [1] was a Swedish immunologist.
Fagraeus received a PhD in medicine in 1948 from the Karolinska Institute. In 1949, she was appointed associate professor of bacteriology at Karolinska Institutet in Stockholm. She became head of the virology department at the Swedish Bacteriological Laboratory in 1953. In 1961–1979 she served as the first professor of immunology in Sweden, at Karolinska Institutet. [2] [3]
Fagraeus' doctoral dissertation, 'Antibody Production in relation to the Development of Plasma Cells', attracted international attention and was considered a milestone in modern immunology. In this work, she was the first to show that plasma cells produce antibodies (IgG). [3] [4] Until then, their function was unknown. During her career, she published around 80 scientific publications, and she was particularly focused on the development and maturation of T lymphocytes in the thymus. Among Fagraeus' later contributions was her role in the development of a Swedish polio vaccine, together with Professor Sven Gard. [2]
The work in her PhD dissertation led to the Swedish Medical Society's 'Jubilee Prize' in 1950. The American Association of Immunologists appointed Astrid Fagraeus an honorary member in 1973. A research building at Karolinska Institutet is named after Astrid Fagraeus. [3] [5] [6]
Fagraeus was the daughter of Consul General Isidor Fagraeus and Elsa Bäckström. She married in 1955 the director Sven Wallbom and had the children Kerstin (born 1955) and Ann (born 1956). She is buried at Norra cemetery in Solna. [1] [2]
The Karolinska Institute is a research-led medical university in Solna within the Stockholm urban area of Sweden and one of the foremost medical research institutes globally. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine. The assembly consists of fifty professors from various medical disciplines at the university. The current vice-chancellor of Karolinska Institute is Annika Östman Wernerson, who took office in March 2023.
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Örjan Thomas Ouchterlony was a Swedish bacteriologist and immunologist who is credited with the creation of the Ouchterlony double immuno diffusion test in the 1940s. He was trained at Karolinska Institute, where his received his medical doctorate. He worked at Sweden's State Bacteriology Laboratory from 1935 to 1952. Ouchterlony was a professor of bacteriology at the Medical Faculty of Gothenburg University from 1952 to 1980 and was elected a member of the Royal Swedish Academy of Sciences in 1968. In addition to his laboratory work, he did research in field epidemiology of infectious diseases and worked and lectured in Africa and the United States, as well as in several countries in Europe. Upon his retirement in 1980, the successor to his professorial chair was Jan Holmgren.
The Ouchterlony plate is one of the more frequently used techniques for the identification of antigens and antibodies, by measurement of diffusion gradients in gel. Among its many applications has been the search for tumor-specific antigens. The technique was introduced by Örjan Ouchterlony of Sweden, in 1948, initially for the in vitro testing of the toxin-producing capacity of diphtheria bacteria. The technique was proved well suited to the analysis of complex serological systems, including analysis that helped to elucidate the structural heterogeneity of immunoglobulins. Ouchterlony reviewed the history of the developments, which extends back to the late Nineteenth Century.
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SciLifeLab is a world-leading Swedish national center for large-scale research and one of the largest molecular biology research laboratories in Europe at the forefront of innovation in life sciences research, computational biology, bioinformatics, training and services in molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience.
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