Bacoside A

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Chemical structure of bacoside A3, a major constituent of bacoside A Bacoside A3.svg
Chemical structure of bacoside A3, a major constituent of bacoside A

Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri . [1] Its major constituents include the saponins bacoside A3, bacopaside II, bacopasaponin C, and jujubogenin isomer of bacopasaponin C. [2] [3] The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity. [4] [5] [6] [7] [8] [9] [10] [11]

References

  1. ↑ Majumdar; et al. (2013). "Bacosides and Neuroprotection". Natural Products. pp. 3639–3660. doi:10.1007/978-3-642-22144-6_157. ISBN   978-3-642-22143-9.
  2. ↑ M. Deepak; G. K. Sangli; P. C. Arun; A. Amit (January–February 2005). "Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC". Phytochemical Analysis. 16 (1): 24–29. Bibcode:2005PChAn..16...24D. doi:10.1002/pca.805. PMID   15688952.
  3. ↑ "Bacoside A, mixture of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C". Sigma-Aldrich.
  4. ↑ Thomas, RB; Joy, S; Ajayan, MS; Paulose, CS (2013). "Neuroprotective Potential of Bacopa monnieri and Bacoside a Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats". Cellular and Molecular Neurobiology . 33 (8): 1065–74. doi:10.1007/s10571-013-9973-0. PMC   11497905 . PMID   23975094. S2CID   9733669.
  5. ↑ Russo; Borrelli (2005). "Bacopa monniera, a reputed nootropic plant: an overview". Phytomedicine. 12 (4): 305–317. doi:10.1016/j.phymed.2003.12.008. PMID   15898709.
  6. ↑ Aguiar, Sebastian; Borowski, Thomas (2013). "Neuropharmacological Review of the Nootropic Herb Bacopa monnieri". Rejuvenation Research. 16 (4): 313–326. doi:10.1089/rej.2013.1431. PMC   3746283 . PMID   23772955.
  7. ↑ Bhattacharya, SK; Bhattacharya, A; Kumar, A; Ghosal, S (2000). "Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus". Phytother Res. 14 (3): 174–179. doi:10.1002/(sici)1099-1573(200005)14:3<174::aid-ptr624>3.0.co;2-o. PMID   10815010.
  8. ↑ Anbarasi, K; Vani, G; Balakrishna, K; Devi, CS (2006). "Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats". Life Sci. 78 (12): 1378–1384. doi:10.1016/j.lfs.2005.07.030. PMID   16226278.
  9. ↑ Anbarasi, K; Sabitha, KE; Devi, CS (2005). "Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A.". Environ Toxicol Pharmacol. 20 (2): 345–350. Bibcode:2005EnvTP..20..345A. doi:10.1016/j.etap.2005.03.006. PMID   21783610.
  10. ↑ Vohora, D; Pal, SN; Pillai, KK (2000). "Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant". J Ethnopharmacol. 71 (3): 383–390. doi:10.1016/s0378-8741(99)00213-5. PMID   10940574.
  11. ↑ Hota, SK; Barhwal, K; Baitharu, I; Prasad, D; Singh, SB; Ilavazhagan, G (2009). "Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment". Neurobiol Dis. 34 (1): 23–39. doi:10.1016/j.nbd.2008.12.006. PMID   19154788. S2CID   207064319.
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