BerEp4

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Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4. BCC with squamous cell metaplasia with HE and BerEP4 staining.jpg
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4.
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen's Disease. At bottom, columnar epithelium in normal sweat glands stain positive too. Superficial BCC with HE and BerEP4.jpg
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease. At bottom, columnar epithelium in normal sweat glands stain positive too.

BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC). [2] It is an antibody to EpCAM (epithelial cell adhesion molecule). [1]

Contents

Clinical use

BerEp4 has a high sensitivity and specificity in being positive only in BCC cells. [1] BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body. [3] It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4). [3] [4]

See also

References

  1. 1 2 3 4 Sunjaya, Anthony Paulo; Sunjaya, Angela Felicia; Tan, Sukmawati Tansil (2017). "The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma". Journal of Skin Cancer. 2017: 1–10. doi: 10.1155/2017/2692604 . ISSN   2090-2905. PMC   5804366 . PMID   29464122.
  2. ↑ "Ber-EP4". e-immunohistochemistry.info. Retrieved 24 May 2017.
  3. 1 2 "Test ID: BEREP - Ber-EP4 (Epithelial Cell Adhesion Molecule/EPCAM) Immunostain, Technical Component Only". Mayo Clinic Laboratories. Retrieved 2019-12-16.
  4. ↑ Ordóñez, Nelson G. (1998). "Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of the Literature". American Journal of Clinical Pathology. 109 (1): 85–89. doi: 10.1093/ajcp/109.1.85 . ISSN   0002-9173. PMID   9426522.
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