Stain | Cell, material, and/or structure(s) stained | Condition(s) in which stain is positive |
---|
Actin-specific enolase | | Infantile digital fibromatosis |
AE1/AE3 | | Squamous cell carcinoma |
Alcian blue | | Lipoid proteinosis Papular mucinosis Scleredema Pretibial myxedema Mucopolysaccharidoses |
Alizarin red | | Calcinosis cutis |
Azure A | Mast cell | Mastocytosis |
Bcl-2 | | Basal cell carcinoma Primary cutaneous marginal zone lymphoma Diffuse large B-cell lymphoma leg type |
Bcl-6 | | Primary cutaneous follicular lymphoma |
BerEp4 | | Desmoplastic trichoepithelioma Basal cell carcinoma |
Brown–Brenn | | Eumycotic mycetoma |
CAM 5.2 | | Merkel cell carcinoma |
CCR7 | | Melanoma |
Carcinoembryonic antigen (CEA) | Eccrine gland | Extramammary Paget's disease Microcystic adnexal carcinoma Eccrine poroma |
CD1a | Langerhans cell | Langerhans cell histiocytosis Indeterminate cell histiocytosis |
CD4 | | Mycosis fungoides Sézary syndrome |
CD5 | | Chronic lymphocytic leukemia |
CD8 | | Pagetoid reticulosis |
CD10 | | Renal cell carcinoma |
CD15 | | Hodgkin's disease |
CD20 | | Primary cutaneous marginal zone lymphoma Primary cutaneous follicular lymphoma Diffuse large B-cell lymphoma leg type |
CD30 (Ki-1) | | Lymphomatoid papulosis Primary cutaneous anaplastic large cell lymphoma Eosinophilic ulcer of the oral mucosa Hodgkin's disease |
CD31 | Endothelial cell | Kaposi's sarcoma Angiosarcoma Intravascular large B-cell lymphoma |
CD34 | Dermal dendritic cell | Desmoplastic trichoepithelioma Spindle cell lipoma Angiosarcoma Dermatofibrosarcoma protuberans Atypical fibroxanthoma Pleomorphic fibroma Intravascular large B-cell lymphoma |
CD38 | Plasma cell | Multiple myeloma Plasmablastic lymphoma Pagetoid reticulosis |
CD44 | | Merkel cell carcinoma |
CD56 | | Extranodal natural killer cell lymphoma Merkel cell carcinoma |
CD68 | | Benign cephalic histiocytosis Generalized eruptive histiocytosis Indeterminate cell histiocytosis Juvenile xanthogranuloma Necrobiotic xanthogranuloma Giant cell reticulohistiocytoma Multicentric reticulohistiocytosis Xanthoma disseminatum Rosai–Dorfman disease Atypical fibroxanthoma Melanoma |
CD79a | | Primary cutaneous marginal zone lymphoma Primary cutaneous follicular lymphoma Diffuse large B-cell lymphoma leg type |
CD117 | Mast cell | Mastocytosis |
CD138 | Plasma cell | Multiple myeloma Plasmablastic lymphoma |
CD207 (Langerin) | Langerhans cell | Langerhans cell histiocytosis |
Chloracetate esterase (Leder) | Mast cell | Mastocytosis |
Chromogranin A | | Merkel cell carcinoma |
Cystokeratin 7 | | Paget's disease (breast and extramammary) |
Cytokeratin 20 | | Extramammary Paget's disease of endodermal origin Merkel cell carcinoma |
Colloidal iron | | Papular mucinosis Scleredema Pretibial myxedema |
Congo red | | Amyloidosis Colloid milium |
Crystal violet | | Amyloidosis Colloid milium |
D2-40 | | Lymphangioma circumscriptum |
de Galantha | | Pseudogout |
Dylon | | Amyloidosis |
Epithelial membrane antigen (EMA) | Eccrine gland Sebaceous gland | Paget's disease extramammary Paget's disease Microcystic adnexal carcinoma Sebaceous carcinoma Renal cell carcinoma Schwannoma |
Factor VIII | | Dabska-type hemangioendothelioma Angiosarcoma |
Factor XIII | | Cutaneous focal mucinosis |
Factor XIIIa | Dermal dendritic cell | Dermatofibroma Epithelioid cell histiocytoma |
Fite | | Leprosy Nocardiosis [nb 1] |
Fontana-Masson | Cryptococcus neoformans | Cryptococcus |
Giemsa | Mast cell | Mastocytosis Mucopolysaccharidoses |
Gomori methenamine silver | Histoplasma capsulatum Blastomyces dermatitidis Coccidioides immitis Paracoccidioides brasiliensis | Histoplasmosis Blastomycosis Coccidioidomycosis Paracoccidioidomycosis |
Gross cystic disease fluid protein 15 (GCDFP-15) | Apocrine gland | Extramammary Paget's disease of cutaneous origin |
HAM56 | Histiocyte | Dermatofibroma |
HMB45 | Gp100 (pmel17, silver protein) | Melanoma [nb 2] |
India | Cryptococcus neoformans | Cryptococcus |
KP-1 | Histiocyte | Dermatofibroma |
LYVE-1 | | Kaposi's sarcoma |
MAC387 | Histiocyte | |
MART-1 (MART-1) | | Melanoma |
Masson's trichrome | | Infantile digital fibromatosis |
Mel-5 | TYRP1 | Melanoma |
Methylene blue | Mast cell | Mastocytosis Ochronosis |
MIB-1 | | Melanoma |
Muscle-specific actin | | Glomus tumor Dermatofibroma Infantile myofibromatosis |
Neurofilament | | Neurofibroma |
Neuro-specific enolase | | Merkel cell carcinoma |
Non-aqueous alcoholic eosin stain (NAES) | | Pseudogout |
Oil red O | | Sebaceous carcinoma Angiokeratoma corporis diffusum Subcutaneous fat necrosis of the newborn |
Peanut agglutinin | | Basal cell carcinoma |
Phosphotungsten acid-hematoxylin (PTAH) | | Infantile digital fibromatosis |
Pogoda red | | Amyloidosis |
Protein gene product 9.5 (PGP9.5) | | Nerve sheath myxoma |
Silver nitrate | Urate crystal | Gout |
Sirius red | | Amyloidosis |
Smooth muscle actin (SMA) | | Angiomyxoma Leiomyosarcoma |
SOX10 | Neuroectodermal neoplasms of neural crest origin, especially: [1] - Melanoma, although desmoplastic melanomas may be only focally positive.
- Nevus
|
Sudan IV | | Leprosy |
Sudan black | | Sebaceous carcinoma |
Synaptophysin | | Merkel cell carcinoma |
S100 | Melanocyte Langerhans cell Schwann cell Chondrocyte Adipocyte Eccrine gland | Langerhans cell histiocytosis Indeterminate cell histiocytosis Schwannoma Neurofibroma Nerve sheath myxoma (Cellular neurothekeoma) Extraskeletal chondroma |
Thioflavin T | | Amyloidosis Colloid milium |
Toluidine blue | Mast cell | Mastocytosis Mucopolysaccharidoses Papular mucinosis Scleredema Pretibial myxedema |
Tryptase | Mast cell | Mastocytosis |
Tyrosinase | Tyrosinase | Melanoma |
Ulex eropaeus agglutinin | | Dabska-type hemangioendothelioma |
VEGF-3 | | Dabska-type hemangioendothelioma |
VEGFR-3 | | Kaposi's sarcoma |
Verhoeff van Gieson | Collagen Elastin | Elastosis perforans serpiginosa Acquired perforating dermatosis Perforating periumbilical calcific elastosis Pseudoxanthoma elasticum |
Vimentin | Non-specific mesenchymal components | Melanoma Glomus tumor Dermatofibroma Pleomorphic fibroma of the skin Epithelioid cell histiocytoma |
von Kossa | Calcium | Calcinosis cutis Pseudoxanthoma elasticum |
Wade | | Leprosy |
Wright | Blood cells | Transient neonatal pustular melanosis [nb 3] Erythema toxicum neonatorum [nb 4] > Granuloma inguinale |
Ziehl–Neelsen_stain | | Leprosy [nb 1] |