There are many human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system
Condition | Associated HLA allele(s) |
---|---|
Fixed drug eruption | B22 |
Lichen planus | DR1 DR2 DRw9 DR10 Bw15 B8 |
Psoriasis | Cw6 DR406 |
Psoriatic arthritis | B27 |
Ankylosing spondylitis | B27 |
Reactive arthritis | B27 |
Acute anterior uveitis | B27 |
Behçet's disease | B51 |
Dermatitis herpetiformis | DQw2 DR3 B8 |
Pemphigus vulgaris | DR4 DRw6 Dw10 |
Herpes gestationis | DR3 DR4 |
Epidermolysis bullosa acquisita | DR2 |
Subacute cutaneous lupus erythematosus | DR3 |
Dermatomyositis | DQA1 DR3 B8 DRw52 |
Alopecia areata | DR5 |
Sjögren's syndrome | DR3 DQ2 |
Herpes simplex virus-related erythema multiforme | B12 |
Chronic idiopathic urticaria | DR4 DQ8 |
Actinic prurigo | DR4 subtype DRB1*0407 |
Systemic lupus erythematosus | DR3 DR2 |
Generalized granuloma annulare | Bw35 |
Lichen sclerosus | DQ7 |
Early onset and severe psoriasis | B17 |
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment.