List of cutaneous conditions associated with internal malignancy

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This is a list of cutaneous conditions associated with internal malignancy; skin markers of internal cancer. [1] It does not include skin infections associated with cancer or cancers that spread to skin. [1] Some have stronger associations with cancers than others. [2]

Contents

Cutaneous conditions associated with internal benign tumors and/or malignancies
Cutaneous conditionInternal malignancy
Erythema gyratum repens Lung cancer
Hypertrichosis lanuginosa acquisita Lung cancer
Paraneoplastic pemphigus Non-Hodgkin lymphoma [nb 1]
Chronic lymphocytic leukemia
Castleman's disease [nb 1]
Sarcoma
Thymoma
Tripe palms Lung cancer
Tripe palms with acanthosis nigricans Stomach cancer
Pityriasis rotunda Hepatocellular carcinoma
Migratory thrombophlebitisPancreatic adenocarcinoma
Leser–Trélat sign Gastrointestinal adenocarcinoma
Acquired ichthyosisHodgkin disease
Pityriasis rotundaHepatocellular carcinoma
Paraneoplastic pigmentationSmall cell bronchial carcinoma
Acrokeratosis paraneoplastica Squamous cell carcinoma of the upper respiratory or gastrointestinal

tracts

Necrolytic migratory erythemaGlucagon secreting

pancreatic islet cell adenoma

Dermatomyositis Lung cancer in men, breast and gynaecological tumours in women and colorectal cancers in both sexes
Scleroderma‐like skin changesCarcinoid syndrome
Paraneoplastic pemphigusB‐cell proliferations and thymoma or thymoma‐like neoplasms; specifically Non Hodgkin's lymphoma (42%)
Dermatitis herpetiformis Lymphoma
Porphyria cutanea tarda and variegate porphyriasHepatocellular Carcinoma
Erythroderma and exfoliative dermatitisMycosis fungoides or Sézary syndrome
Pyoderma gangrenosum Hematological malignancy
Sweet syndrome Hematological malignancy

Footnotes

  1. 1 2 Non-Hodgkin lymphoma is the most common cause of paraneoplastic pemphigus in adults. Castleman's disease is the most common cause of paraneoplastic pemphigus in children.

See also

Related Research Articles

<span class="mw-page-title-main">Pemphigus</span> Blistering autoimmune diseases

Pemphigus is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek root pemphix, meaning "pustule".

<span class="mw-page-title-main">Syringoma</span> Medical condition

Syringomas are benign eccrine sweat duct tumors, typically found clustered on eyelids, although they may also be found in the armpits, abdomen, chest, neck, scalp, or groin area, including genitals, in a symmetric pattern. They are skin-colored or yellowish firm, rounded bumps, 1–3 mm in diameter, and may be confused with xanthoma, milia, hidrocystoma, trichoepithelioma, and xanthelasma. They are more common in women and are most commonly found in middle-aged Asian women. While they can present at any time in life, they typically present during adolescence. They are usually not associated with any other symptoms, although can sometimes cause itchiness or irritation.

<span class="mw-page-title-main">Erythema elevatum diutinum</span> Medical condition

Erythema elevatum diutinum is a form of vasculitis.

Paraneoplastic acrokeratosis, or Bazex syndrome is a cutaneous condition characterized by psoriasiform changes of hands, feet, ears, and nose, with involvement of the nails and periungual tissues being characteristic and indistinguishable from psoriatic nails. The condition is associated with carcinomas of the upper aerodigestive tract.

Tripe palms, also known as acanthosis palmaris, is a medical sign characterized by thick ridged velvety palms, typically as part of a paraneoplastic syndrome. It resembles the lining of the stomach of some animals (tripe). Other signs that may be noted at the same time include most frequently acanthosis nigricans (AN), and less commonly finger clubbing and Leser-Trélat sign.

References

  1. 1 2 Wick, Mark R.; Patterson, James W. (July 2019). "Cutaneous paraneoplastic syndromes". Seminars in Diagnostic Pathology. 36 (4): 211–228. doi:10.1053/j.semdp.2019.01.001. ISSN   0740-2570. PMID   30736994.
  2. Fonia, Athina; Baran, Robert (2021). "Cutaneous paraneoplastic syndromes with nail involvement". In Lipner, Shari (ed.). Nail Disorders: Diagnosis and Management, An Issue of Dermatologic Clinics. Elsevier. pp. 175–182. ISBN   978-0-323-70924-8.

Bibliography