This is a list of cutaneous conditions associated with internal malignancy; skin markers of internal cancer. [1] It does not include skin infections associated with cancer or cancers that spread to skin. [1] Some have stronger associations with cancers than others. [2]
Cutaneous condition | Internal malignancy |
---|---|
Erythema gyratum repens | Lung cancer |
Hypertrichosis lanuginosa acquisita | Lung cancer |
Paraneoplastic pemphigus | Non-Hodgkin lymphoma [nb 1] Chronic lymphocytic leukemia Castleman's disease [nb 1] Sarcoma Thymoma |
Tripe palms | Lung cancer |
Tripe palms with acanthosis nigricans | Stomach cancer |
Pityriasis rotunda | Hepatocellular carcinoma |
Migratory thrombophlebitis | Pancreatic adenocarcinoma |
Leser–Trélat sign | Gastrointestinal adenocarcinoma |
Acquired ichthyosis | Hodgkin disease |
Pityriasis rotunda | Hepatocellular carcinoma |
Paraneoplastic pigmentation | Small cell bronchial carcinoma |
Acrokeratosis paraneoplastica | Squamous cell carcinoma of the upper respiratory or gastrointestinal tracts |
Necrolytic migratory erythema | Glucagon secreting pancreatic islet cell adenoma |
Dermatomyositis | Lung cancer in men, breast and gynaecological tumours in women and colorectal cancers in both sexes |
Scleroderma‐like skin changes | Carcinoid syndrome |
Paraneoplastic pemphigus | B‐cell proliferations and thymoma or thymoma‐like neoplasms; specifically Non Hodgkin's lymphoma (42%) |
Dermatitis herpetiformis | Lymphoma |
Porphyria cutanea tarda and variegate porphyrias | Hepatocellular Carcinoma |
Erythroderma and exfoliative dermatitis | Mycosis fungoides or Sézary syndrome |
Pyoderma gangrenosum | Hematological malignancy |
Sweet syndrome | Hematological malignancy |
Pemphigus is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek root pemphix, meaning "pustule".
Syringomas are benign eccrine sweat duct tumors, typically found clustered on eyelids, although they may also be found in the armpits, abdomen, chest, neck, scalp, or groin area, including genitals, in a symmetric pattern. They are skin-colored or yellowish firm, rounded bumps, 1–3 mm in diameter, and may be confused with xanthoma, milia, hidrocystoma, trichoepithelioma, and xanthelasma. They are more common in women and are most commonly found in middle-aged Asian women. While they can present at any time in life, they typically present during adolescence. They are usually not associated with any other symptoms, although can sometimes cause itchiness or irritation.
Erythema elevatum diutinum is a form of vasculitis.
Paraneoplastic acrokeratosis, or Bazex syndrome is a cutaneous condition characterized by psoriasiform changes of hands, feet, ears, and nose, with involvement of the nails and periungual tissues being characteristic and indistinguishable from psoriatic nails. The condition is associated with carcinomas of the upper aerodigestive tract.
Tripe palms, also known as acanthosis palmaris, is a medical sign characterized by thick ridged velvety palms, typically as part of a paraneoplastic syndrome. It resembles the lining of the stomach of some animals (tripe). Other signs that may be noted at the same time include most frequently acanthosis nigricans (AN), and less commonly finger clubbing and Leser-Trélat sign.