List of target antigens in pemphigus

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Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Contents

Target antigens for the different pemphigus variants
Pemphigus variant Antibody isotype Antigen Molecular weight (KDa)
Mucosal pemphigus vulgaris IgG Desmoglein 3 130
Mucocutaneous pemphigus vulgaris IgG Desmoglein 3
Desmoglein 1
130
160
Pemphigus foliaceus IgG Desmoglein 1 160
Paraneoplastic pemphigus IgG Desmoglein 3
Desmoglein 1
BPAG1 [nb 1]
Plectin
Desmoplakin I [nb 2]
Desmoplakin II
Envoplakin
Periplakin
Alpha-2-macroglobulin-like-1
130
160
230
500
250
210
210
190
170
Drug-induced pemphigus IgG Desmoglein 3
Desmoglein 1
130
160
Subcorneal pustular dermatosis type of IgA pemphigus IgA1 Desmocollin 1 110/100
Intraepidermal neutrophilic type of IgA pemphigus IgA1 Unknown
Pemphigus erythematosus (Senear–Usher syndrome) [nb 3] IgG Desmoglein 1 160
Fogo selvagem IgG Desmoglein 1 160
Pemphigus vegetans IgG Desmoglein 3 130
Pemphigus vegetans of Hallopeau [nb 4] IgG Desmoglein 3 130
Pemphigus vegetans of Neumann [nb 4] IgG Desmoglein 3 130
Pemphigus herpetiformis IgG Desmoglein 3
Desmoglein 1
130
160

Footnotes

  1. Notably not BPAG2
  2. Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
  3. Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
  4. 1 2 Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.

See also

Related Research Articles

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<span class="mw-page-title-main">Pemphigoid</span> Autoimmune blistering diseases

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Epidermolysis bullosa acquisita, also known as acquired epidermolysis bullosa, is a longterm autoimmune blistering skin disease. It generally presents with fragile skin that blisters and becomes red with or without trauma. Marked scarring is left with thin skin, milia and nail changes. It typically begins around age 50-years.

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References