There are many different keratin proteins normally expressed in the human integumentary system.
| Keratin type | Location of expression |
|---|---|
| 1 | Suprabasal epidermis of skin |
| 2 (2e) | Granular layer |
| 3 | Cornea |
| 4 | Suprabasal epidermis of mucosa |
| 5 | Basal layer |
| 6a | Suprabasal palmoplantar skin |
| 6b | Basal palmoplantar skin Nail bed Hair follicle |
| 7 | |
| 8 | |
| 9 | Suprabasal palmoplantar skin |
| 10 | Suprabasal epidermis |
| 11 | |
| 12 | Cornea |
| 13 | Suprabasal epidermis of mucosa |
| 14 | Basal layer |
| 15 | Basal layer of mucosa |
| 16 | Suprabasal palmoplantar skin |
| 17 | Basal palmoplantar skin |
| 18 | |
| 19 | Bulge region of the hair follicle |
| 20 | Merkel cell |
| 21 |
Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease associated with autoimmunity to type VII collagen within anchoring fibril structures that are located at the dermoepidermal junction.