There are many different keratin proteins normally expressed in the human integumentary system.
Keratin type | Location of expression |
---|---|
1 | Suprabasal epidermis of skin |
2 (2e) | Granular layer |
3 | Cornea |
4 | Suprabasal epidermis of mucosa |
5 | Basal layer |
6a | Suprabasal palmoplantar skin |
6b | Basal palmoplantar skin Nail bed Hair follicle |
7 | |
8 | |
9 | Suprabasal palmoplantar skin |
10 | Suprabasal epidermis |
11 | |
12 | Cornea |
13 | Suprabasal epidermis of mucosa |
14 | Basal layer |
15 | Basal layer of mucosa |
16 | Suprabasal palmoplantar skin |
17 | Basal palmoplantar skin |
18 | |
19 | Bulge region of the hair follicle |
20 | Merkel cell |
21 |
Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease associated with autoimmunity to type VII collagen within anchoring fibril structures that are located at the dermoepidermal junction.