Langerhans cell

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Langerhans cell
Dendritic cells.jpg
Section of skin showing large numbers of Langerhans cells in the epidermis. ( M. ulcerans infection, S100 immunoperoxidase stain.)
Details
System Immune system
Location Skin and mucosa
Function Dendritic cell
Identifiers
MeSH D007801
FMA 63072
Anatomical terms of microanatomy
The representation of Langerhans cells in the Cell Ontology. A portion of the Cell Ontology is shown with ovals corresponding to cell types defined in the ontology and arrows corresponding to relations between those cell types. Langerhans cell is represented by a yellow oval; blue arrows correspond to is_a relations, and orange arrows correspond to develops_from relations. Only a subset of Langerhans cell parent types are included in the figure. The representation of Langerhans cells in the Cell Ontology.jpg
The representation of Langerhans cells in the Cell Ontology. A portion of the Cell Ontology is shown with ovals corresponding to cell types defined in the ontology and arrows corresponding to relations between those cell types. Langerhans cell is represented by a yellow oval; blue arrows correspond to is_a relations, and orange arrows correspond to develops_from relations. Only a subset of Langerhans cell parent types are included in the figure.

A Langerhans cell (LC) is a tissue-resident macrophage of the skin [2] once thought to be a resident dendritic cell. [3] These cells contain organelles called Birbeck granules. They are present in all layers of the epidermis and are most prominent in the stratum spinosum. [4] They also occur in the papillary dermis, particularly around blood vessels, [4] as well as in the mucosa of the mouth, foreskin, and vaginal epithelium. [5] They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis (LCH).

Contents

Function

In skin infections, the local Langerhans cells take up and process microbial antigens to become fully functional antigen-presenting cells. [6]

Generally, tissue-resident macrophages are involved in immune homeostasis and the uptake of apoptotic bodies. However, Langerhans cells can also take on a dendritic cell-like phenotype and migrate to lymph nodes to interact with naive T-cells.[ medical citation needed ]

Langerhans cells derive from primitive erythro-myeloid progenitors that arise in the yolk sac outside the embryo in the first trimester of pregnancy, and under normal circumstances persist throughout life, being replenished by local proliferation as necessary. If the skin becomes severely inflamed, perhaps because of infection, blood monocytes are recruited to the affected region and differentiate into replacement LCs. [7]

Langerin is a protein found in Langerhans cells, [8] and dendritic cells. [9]

LCs contain a large amount of cannabinoid receptor type 2 (CB2), that by activation by agonists, attenuate both the recruitment of eosinophils and ear swelling in chronic contact dermatitis induced by repeated challenge. [10]

Clinical significance

Langerhans cell histiocytosis

In the rare disease Langerhans cell histiocytosis (LCH), an excess of cells similar to these cells are produced. However LCH cells stain positive to CD14 which is a monocyte marker and shows a different, hematopoietic origin for the disorder. [11] LCH can cause damage to skin, bone and other organs.[ citation needed ]

HIV

Langerhans cells may be initial cellular targets in the sexual transmission of HIV, [12] and may be a target, reservoir, and vector of dissemination. [13] Langerhans cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of HIV infection relative to foreskin and vaginal mucosa. [5]

Human papillomavirus

High-risk human papillomaviruses (HPV) are sexually transmitted viruses causally associated with several cancers including cervical, vaginal, anal, and head and neck cancers that cause significant morbidity and mortality worldwide. [14] [15] [16] [17] Over half of all cervical cancer cases are associated with HPV16, the most common of the cancer-causing high-risk genotypes. [18] During its natural life cycle, HPV16 infects the basal cells of the epithelium and interacts with Langerhans cells within the epithelial layer, [19] which are responsible for initiating immune responses against epithelial invading pathogens. [20] However, HPV does not activate Langerhans cells in vitro, and this may represent a key mechanism by which HPV evades immune detection in vivo. [21] [22] [23] [24] Specifically, HPV16 entry into Langerhans cells via the annexin A2/S100A10 heterotetramer results in suppressive signaling and lack of Langerhans cell-mediated immune responses. [25] This Langerhans cell-targeted immune escape mechanism seems to be conserved among different HPV genotypes enabling these viruses to remain undetected in the absence of other inflammatory events. [26] T cells exposed to these inactivated Langerhans cells are not anergic, and can be activated against HPV upon receiving the appropriate stimuli at a later time point. [27]

It was demonstrated that Langerhans cells in HPV-induced cervical lesions were spherical, lacked dendrites, and secreted the suppressive cytokine IL-10 in vivo. [28] The authors further demonstrated that the number of IL-10 secreting immunosuppressive Langerhans cells, and the amount of IL-10 produced in lesions, corresponded with the severity of histopathology and HPV viral load, providing evidence of an active immunosuppressive mechanism employed by HPV that targets Langerhans cells in vivo.[ citation needed ]

Dengue fever

Langerhans cells are also the initial target of the virus that causes dengue fever during its development. [29]

Declining function during ageing

During ageing the capacity of Langerhans cells to migrate declines. [30] This compromises immunity and exposes the skin to infectious diseases and cancer.[ citation needed ]

History

Langerhans cells are named after Paul Langerhans, a German physician and anatomist, who discovered the cells at the age of 21 while he was a medical student. [31] Because of their dendrite-like appearance, he mistakenly identified the cells as part of the nervous system. [32]

See also

Related Research Articles

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<span class="mw-page-title-main">Human papillomavirus infection</span> Human disease

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<span class="mw-page-title-main">Langerhans cell histiocytosis</span> Medical condition

Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes.

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<span class="mw-page-title-main">Langerin</span>

Langerin (CD207) is a type II transmembrane protein which is encoded by the CD207 gene in humans. It was discovered by scientists Sem Saeland and Jenny Valladeau as a main part of Birbeck granules. Langerin is C-type lectin receptor on Langerhans cells (LCs) and in mice also on dermal interstitial CD103+ dendritic cells (DC) and on resident CD8+ DC in lymph nodes.

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References

  1. ↑ Masci, Anna; Arighi, Cecilia N; Diehl, Alexander D; Lieberman, Anne E; Mungall, Chris; Scheuermann, Richard H; Smith, Barry; Cowell, Lindsay G (2009). "An improved ontological representation of dendritic cells as a paradigm for all cell types". BMC Bioinformatics. 10: 70. doi:10.1186/1471-2105-10-70. PMC   2662812 . PMID   19243617.
  2. ↑ Doebel, T.; Voisin, B.; Nagao, K. (2017). "MeSH Browser". Trends in Immunology. 38 (11): 817–828. doi:10.1016/j.it.2017.06.008. PMID   28720426.
  3. ↑ "MeSH Browser".
  4. 1 2 Young, Barbara; Heath, John W. (2000). Wheater's Functional Histology (4th ed.). Churchill Livingstone. p. 162. ISBN   0-443-05612-9.
  5. 1 2 Hussain, LA; Lehner, T (1995). "Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia". Immunology. 85 (3): 475–84. PMC   1383923 . PMID   7558138.
  6. ↑ Monnot GC, Wegrecki M, Cheng TY, Chen YL, Sallee BN, Chakravarthy R, Karantza IM, Tin SY, Khaleel AE, Monga I, Uwakwe LN, Tillman A, Cheng B, Youssef S, Ng SW, Shahine A, Garcia-Vilas JA, Uhlemann AC, Bordone LA, Han A, Rohde CH, Ogg G, Moody DB, Rossjohn J, de Jong A (January 2023). "Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a". Nature Immunology. 24 (1): 110–122. doi:10.1038/s41590-022-01375-z. PMC   10389259 . PMID   35265979. S2CID   255039948.
  7. ↑ Collin, Matthew; Milne, Paul (2016). "Langerhans cell origin and regulation". Current Opinion in Hematology. 23 (1): 28–35. doi:10.1097/MOH.0000000000000202. PMC   4685746 . PMID   26554892.
  8. ↑ Valladeau, Jenny; Dezutter-Dambuyant, Colette; Saeland, Sem (2003). "Langerin/CD207 Sheds Light on Formation of Birbeck Granules and Their Possible Function in Langerhans Cells". Immunologic Research. 28 (2): 93–107. doi:10.1385/IR:28:2:93. PMID   14610287. S2CID   37296843.
  9. ↑ Poulin, Lionel Franz; Henri, Sandrine; de Bovis, Béatrice; Devilard, Elisabeth; Kissenpfennig, Adrien; Malissen, Bernard (2007). "The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells" (PDF). Journal of Experimental Medicine. 204 (13): 3119–31. doi:10.1084/jem.20071724. PMC   2150992 . PMID   18086861. Archived from the original (PDF) on 2018-07-19. Retrieved 2018-11-04.
  10. ↑ Oka, Saori (2006). "Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice". Journal of Immunology. 177 (12): 8796–9505. doi: 10.4049/jimmunol.177.12.8796 . PMID   17142782. S2CID   11946479 . Retrieved 2023-03-26.
  11. ↑ "NCI Summary View > Urology - Yale School of Medicine". medicine.yale.edu. Archived from the original on 17 June 2019. Retrieved 19 April 2018.
  12. ↑ Kawamura, Tatsuyoshi; Kurtz, Stephen E.; Blauvelt, Andrew; Shimada, Shinji (2005). "The role of Langerhans cells in the sexual transmission of HIV". Journal of Dermatological Science. 40 (3): 147–55. doi:10.1016/j.jdermsci.2005.08.009. PMID   16226431.
  13. ↑ Dezutter-Dambuyant, C; Charbonnier, AS; Schmitt, D (December 1995). "Cellules dendritiques épithéliales et infection par HIV-1 in vivo et in vitro" [Epithelial dendritic cells and HIV-1 infection in vivo and in vitro]. Pathologie Biologie (in French). 43 (10): 882–8. PMID   8786894.
  14. ↑ Walboomers, J. M.; Jacobs, M. V.; Manos, M. M.; Bosch, F. X.; Kummer, J. A.; Shah, K. V.; Snijders, P. J.; Peto, J.; Meijer, C. J. (1999-09-01). "Human papillomavirus is a necessary cause of invasive cervical cancer worldwide". The Journal of Pathology. 189 (1): 12–19. doi:10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F. ISSN   0022-3417. PMID   10451482. S2CID   1522249.
  15. ↑ Arbyn, M.; Castellsagué, X.; de Sanjosé, S.; Bruni, L.; Saraiya, M.; Bray, F.; Ferlay, J. (2011-12-01). "Worldwide burden of cervical cancer in 2008". Annals of Oncology. 22 (12): 2675–2686. doi: 10.1093/annonc/mdr015 . ISSN   1569-8041. PMID   21471563.
  16. ↑ Haedicke, Juliane; Iftner, Thomas (2013-09-01). "Human papillomaviruses and cancer". Radiotherapy and Oncology. 108 (3): 397–402. doi: 10.1016/j.radonc.2013.06.004 . ISSN   1879-0887. PMID   23830197.
  17. ↑ HOFFMANN, MARKUS; QUABIUS, ELGAR S.; TRIBIUS, SILKE; HEBEBRAND, LENA; GÖRÖGH, TIBOR; HALEC, GORDANA; KAHN, TOMAS; HEDDERICH, JÜRGEN; RÖCKEN, CHRISTOPH (2013-05-01). "Human papillomavirus infection in head and neck cancer: The role of the secretory leukocyte protease inhibitor". Oncology Reports. 29 (5): 1962–1968. doi:10.3892/or.2013.2327. ISSN   1021-335X. PMC   3658815 . PMID   23467841.
  18. ↑ Bosch, F. X.; Manos, M. M.; Muñoz, N.; Sherman, M.; Jansen, A. M.; Peto, J.; Schiffman, M. H.; Moreno, V.; Kurman, R. (1995-06-07). "Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group". Journal of the National Cancer Institute. 87 (11): 796–802. doi:10.1093/jnci/87.11.796. ISSN   0027-8874. PMID   7791229.
  19. ↑ Stanley, M. A.; Pett, M. R.; Coleman, N. (2007-12-01). "HPV: from infection to cancer". Biochemical Society Transactions. 35 (Pt 6): 1456–1460. doi:10.1042/BST0351456. ISSN   0300-5127. PMID   18031245.
  20. ↑ Merad, Miriam; Ginhoux, Florent; Collin, Matthew (2008-12-01). "Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells". Nature Reviews. Immunology. 8 (12): 935–947. doi:10.1038/nri2455. ISSN   1474-1741. PMID   19029989. S2CID   22286432.
  21. ↑ Fausch, Steven C.; Da Silva, Diane M.; Rudolf, Michael P.; Kast, W. Martin (2002-09-15). "Human papillomavirus virus-like particles do not activate Langerhans cells: a possible immune escape mechanism used by human papillomaviruses". Journal of Immunology. 169 (6): 3242–3249. doi: 10.4049/jimmunol.169.6.3242 . ISSN   0022-1767. PMID   12218143.
  22. ↑ Fausch, Steven C.; Da Silva, Diane M.; Kast, W. Martin (2003-07-01). "Differential uptake and cross-presentation of human papillomavirus virus-like particles by dendritic cells and Langerhans cells". Cancer Research. 63 (13): 3478–3482. ISSN   0008-5472. PMID   12839929.
  23. ↑ Fausch, Steven C.; Fahey, Laura M.; Da Silva, Diane M.; Kast, W. Martin (2005-06-01). "Human papillomavirus can escape immune recognition through Langerhans cell phosphoinositide 3-kinase activation". Journal of Immunology. 174 (11): 7172–7178. doi: 10.4049/jimmunol.174.11.7172 . ISSN   0022-1767. PMID   15905561.
  24. ↑ Fahey, Laura M.; Raff, Adam B.; Da Silva, Diane M.; Kast, W. Martin (2009-11-15). "A major role for the minor capsid protein of human papillomavirus type 16 in immune escape". Journal of Immunology. 183 (10): 6151–6156. doi: 10.4049/jimmunol.0902145 . ISSN   1550-6606. PMC   2947488 . PMID   19864613.
  25. ↑ Woodham, Andrew W.; Raff, Adam B.; Raff, Laura M.; Da Silva, Diane M.; Yan, Lisa; Skeate, Joseph G.; Wong, Michael K.; Lin, Yvonne G.; Kast, W. Martin (2014-05-15). "Inhibition of Langerhans cell maturation by human papillomavirus type 16: a novel role for the annexin A2 heterotetramer in immune suppression". Journal of Immunology. 192 (10): 4748–4757. doi:10.4049/jimmunol.1303190. ISSN   1550-6606. PMC   4019435 . PMID   24719459.
  26. ↑ Da Silva, Diane M.; Movius, Carly A.; Raff, Adam B.; Brand, Heike E.; Skeate, Joseph G.; Wong, Michael K.; Kast, W. Martin (2014-03-01). "Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a μ genotype". Virology. 452–453: 279–286. doi:10.1016/j.virol.2014.01.031. ISSN   1096-0341. PMC   3987942 . PMID   24606705.
  27. ↑ Woodham, Andrew W.; Yan, Lisa; Skeate, Joseph G.; van der Veen, Daniel; Brand, Heike H.; Wong, Michael K.; Da Silva, Diane M.; Kast, W. Martin (December 2016). "T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation". Papillomavirus Research (Amsterdam, Netherlands). 2: 21–30. doi:10.1016/j.pvr.2016.01.002. ISSN   2405-8521. PMC   4862606 . PMID   27182559.
  28. ↑ Prata, Thiago Theodoro Martins; Bonin, Camila Mareti; Ferreira, Alda Maria Teixeira; Padovani, Cacilda Tezelli Junqueira; Fernandes, Carlos Eurico Dos Santos; Machado, Ana Paula; Tozetti, Inês Aparecida (2015-09-01). "Local immunosuppression induced by high viral load of human papillomavirus: characterization of cellular phenotypes producing interleukin-10 in cervical neoplastic lesions". Immunology. 146 (1): 113–121. doi:10.1111/imm.12487. ISSN   1365-2567. PMC   4552506 . PMID   26059395.
  29. ↑ Martina BE, Koraka P, Osterhaus AD (October 2009). "Dengue virus pathogenesis: an integrated view". Clinical Microbiology Reviews. 22 (4): 564–81. doi:10.1128/CMR.00035-09. PMC 2772360. PMID 19822889.
  30. ↑ Pilkington, S; et al. (2018). "Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin". Immunology. 153 (1): 60–70. doi:10.1111/imm.12810. PMC   5721243 . PMID   28777886.
  31. ↑ Langerhans, Paul (1868). "Ueber die Nerven der menschlichen Haut" [On the nerves of the human skin]. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin (in German). 44 (2–3): 325–37. doi:10.1007/BF01959006. S2CID   6282875.
  32. ↑ Online Mendelian Inheritance in Man (OMIM): Langerhans cell histiocytosis - 604856
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