Touton giant cell

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Touton giant cells in a juvenile xanthogranuloma. H&E stain. Juvenile xanthogranuloma - very high mag.jpg
Touton giant cells in a juvenile xanthogranuloma. H&E stain.

Touton giant cells are a type of multinucleated giant cell seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthelasma and xanthogranulomas.They are also found in dermatofibroma. [1]



Touton giant cells are named for Karl Touton, a German botanist and dermatologist. [2] Karl Touton first observed these cells in 1885 and named them "xanthelasmatic giant cells", a name which has since fallen out of favor. [3]


Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. They contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei. [4] [5] The cytoplasm surrounded by the nuclei has been described as both amphophilic and eosinophilic, while the cytoplasm near the periphery of the cell is pale and foamy in appearance. [6]


Touton giant cells are formed by the fusion of macrophage-derived foam cells. It has been suggested that cytokines such as interferon gamma, interleukin-3, and M-CSF may be involved in the production of Touton giant cells. [7] [8]

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  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 14, 15. ISBN   978-1-4160-2999-1.
  2. Aterman, K.; Remmele, W.; Smith, M. (Jun 1988). "Karl Touton and his "xanthelasmatic giant cell." A selective review of multinucleated giant cells". The American Journal of Dermatopathology. 10 (3): 257–269. ISSN   0193-1091. PMID   3068999.
  3. Olson, James (1989). The History of Cancer: An Annotated Bibliography. ABC-CLIO. p. 139. ISBN   9780313258893.
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  6. Sequeira, Fiona; Gandhi, Suneil (2012). "Named cells in dermatology". Indian Journal of Dermatology, Venereology and Leprology. 78 (2): 207–16. doi: 10.4103/0378-6323.93650 . PMID   22421663.
  7. Quinn, Mark; Schepetkin, Igor (2009). "Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells". Journal of Innate Immunology. 1 (6): 509–26. doi:10.1159/000228158. PMC   2919507 . PMID   20375608.
  8. Reiss, AB; Patel, CA (2004). "Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages". Medical Science Monitor . 10 (11): 420–5. PMID   15507847.