Eosinophilic

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Main staining types when using hematoxylin and eosin (H&E). Eosinophilic, basophilic, chromophobic and amphophilic staining.png
Main staining types when using hematoxylin and eosin (H&E).
A basophil granulocyte is surrounded by lightly staining eosinophilic erythrocytes in an H&E staining. Basophil.jpg
A basophil granulocyte is surrounded by lightly staining eosinophilic erythrocytes in an H&E staining.

Eosinophilic (Greek suffix -phil , meaning eosin-loving) describes the staining of tissues, cells, or organelles after they have been washed with eosin, a dye commonly used in histological staining.

Eosin is an acidic dye for staining cell cytoplasm, collagen, and muscle fibers. [1] [2] Eosinophilic describes the appearance of cells and structures seen in histological sections that take up the staining dye eosin. [2] Such eosinophilic structures are, in general, composed of protein. [3]

Eosin is usually combined with a stain called hematoxylin to produce a hematoxylin- and eosin-stained section (also called an H&E stain, HE or H+E section). It is the most widely used histological stain for a medical diagnosis. [3] When a pathologist examines a biopsy of a suspected cancer, they will stain the biopsy with H&E.

Some structures seen inside cells are described as being eosinophilic; for example, Lewy and Mallory bodies. [4] Some cells are also described as eosinophilic, such as Leukocytes. [5]

See also

References

  1. Tubbs, R. Shane; Rizk, Elias; Shoja, Mohammadali; Loukas, Marios; Barbaro, Nicholas; Spinner, Robert J. (2015). Nerves and Nerve Injuries: Vol 1: History, Embryology, Anatomy, Imaging, and Diagnostics. Academic Press. p. 84. ISBN   978-0-12-410447-1.
  2. 1 2 Sharma, Sonal; Khanna, Geetika (2019). Textbook of Pathology and Genetics for Nurses E-Book. Elsevier Health Sciences. p. 9. ISBN   978-8-13-125538-4.
  3. 1 2 Leong, Franz Joel; Dartois, Veronique; Dick, Thomas (2016). A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis. CRC Press. p. 199. ISBN   978-1-43-983530-2.
  4. Eosinophilic. Medline Plus. Accessed March 2nd, 2012.
  5. Dixon, Frank J. (1986). Advances in Immunology, Volume 39. Academic Press. p. 323. ISBN   9780120224395.