Verrucous carcinoma is a type of squamous cell carcinoma that may be associated with HPV infection (may be subtypes 16 or 18, but types 6 and 11 have also been reported, as have HPV negative variants). Several subtypes of verrucous carcinoma have been described. Treatment of verrucous carcinoma with radiation therapy should be avoided due to the risk of anaplastic transformation.
Subtype | Clinical features |
---|---|
Epithelioma cuniculatum (Ackerman tumor, Carcinoma cuniculatum) | Arises on the sole of the foot from wart |
Giant condyloma of Buschke–Löwenstein tumor (Buschke–Löwenstein tumor, Giant condyloma acuminatum) | Genitals affected |
Oral florid papillomatosis | |
Subungual keratoacanthoma | Occurs in the setting of immunosuppression or with epidermolytic hyperkeratosis; May erupt in the setting of systemic lupus erythematosus |
Gottron's carcinoid papillomatosis (Papillomatosis cutis carcinoides, Papillomatosis cutis carcinoides of Gottron–Eisenlohr) |
Verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew tobacco or use snuff orally, so much so that it is sometimes referred to as "Snuff dipper's cancer".
Giant condyloma acuminatum is a rare cutaneous condition characterized by an aggressive, wart-like growth that is a verrucous carcinoma. It is attributed to human papillomavirus.
Papillomatosis cutis carcinoides is a cutaneous condition characterized by verrucous skin lesions, and is due to an HPV infection of the skin.