Bernd Pichler (born 26 December 1969) is a German biomedical engineer and expert in preclinical and molecular imaging as well as in imaging technology. He is Chair of the Department of Preclinical Imaging and Radiopharmacy [1] as well as Director of the Werner Siemens Imaging Center at the University of Tübingen, Germany. [2] He is the dean of the Faculty of Medicine of the University of Tübingen and member of the University Hospital Executive Board of Directors. [3]
Pichler grew up in Pfaffenhofen an der Ilm in Bavaria. After completing his high school education, he studied electrical engineering and biomedical engineering at the Technical University of Munich, Germany. Following his degree, he worked as a PhD student at the Clinic for Nuclear Medicine at the Technical University of Munich and the Max Planck Institute for Physics (Werner Heisenberg Institute). After gaining his doctoral degree (Dr. rer. nat.) in 2001, he initially worked as a post-doctoral research fellow at the Clinic of Nuclear Medicine. He moved to the University of California, Davis, as an Assistance Research Engineer (equal to Assistant Research Professor) in March 2003 and worked in the Department of Biomedical Engineering.
In January 2005, Pichler became Head of the Laboratory for Preclinical Imaging and Imaging Technology at the University of Tübingen and successfully completed his habilitation there in 2007. He has been a Full Professor at the University of Tübingen since 2008 and also Chair of the Department of Preclinical Imaging and Radiopharmacy at the Clinic of Radiology, which is part of University Hospital Tübingen, since January 2011. His professorship is funded by the Werner Siemens Foundation, [4] which has its headquarters in Switzerland.
In May 2020, Pichler was elected dean of the Medical Faculty of the University of Tübingen. [5]
Pichler is primarily conducting research in the development of new imaging processes for fundamental pre-clinical research and clinical usage. He played a major role in the development of an imaging procedure which combines positron emission tomography (PET) and magnetic resonance tomography (MRT) in one device (PET/MR). The laboratory headed by Pichler primarily focuses on fundamental research into new diagnosis and treatment methods in the fields of oncology, neurology, cardiology and immunology. He is holder and applicant of many patents on integrated PET/MR scanners and radioactive tracers.[ citation needed ]
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, 18
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-FDG is commonly used to detect cancer, NaF18
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is widely used for detecting bone formation, and oxygen-15 is sometimes used to measure blood flow.
Bruker Corporation is an American manufacturer of scientific instruments for molecular and materials research, as well as for industrial and applied analysis. It is headquartered in Billerica, Massachusetts, and is the publicly traded parent company of Bruker Scientific Instruments and Bruker Energy & Supercon Technologies (BEST) divisions.
The southern multimammate mouse or southern African mastomys is a species of rodent in the family Muridae which is endemic to southern Africa. It is called a multimammate mouse because it can have 8 to 12 pairs of mammae, in comparison other mouse species only have 5 pairs.
Copper-64 (64Cu) is a positron and beta emitting isotope of copper, with applications for molecular radiotherapy and positron emission tomography. Its unusually long half-life (12.7-hours) for a positron-emitting isotope makes it increasingly useful when attached to various ligands, for PET and PET-CT scanning.
DASB, also known as 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, is a compound that binds to the serotonin transporter. Labeled with carbon-11 — a radioactive isotope — it has been used as a radioligand in neuroimaging with positron emission tomography (PET) since around year 2000. In this context it is regarded as one of the superior radioligands for PET study of the serotonin transporter in the brain, since it has high selectivity for the serotonin transporter.
Positron emission tomography–magnetic resonance imaging (PET–MRI) is a hybrid imaging technology that incorporates magnetic resonance imaging (MRI) soft tissue morphological imaging and positron emission tomography (PET) functional imaging.
Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals. Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution and, at the same time, allows to perform fast dynamic imaging of animals.
11C-UCB-J is a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the human brain.
Heike Brötz-Oesterhelt is a German microbiologist. She is a full professor and holds the Chair of the Department for Microbial Bioactive Compounds at the Interfaculty Institute for Microbiology and Infection Medicine, University of Tübingen, Germany.
Katerina Harvati is a Greek paleoanthropologist and expert in human evolution. She specializes in the broad application of 3-D geometric morphometric and virtual anthropology methods to paleoanthropology. Since 2009, she is full professor and director of Paleoanthropology at the University of Tübingen, Germany. From 2020-2023 she was Director of the Institute for Archaeological Sciences and since 2023 she is Director of the Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tübingen.
The Werner Reichardt Centre for Integrative Neuroscience (CIN) is the common platform for systems neuroscience at the University of Tübingen in Germany. It was installed as a cluster of excellence within the framework of the Excellence Initiative in 2007/2008. About 90 scientists with their research groups – 21 of which are currently supported with excellence initiative funds – form the CIN's membership. The focus of their work is on basic research in systems neurobiology. Based on an interdisciplinary and integrative approach, it encompasses projects rooted in biology, medicine, physics, computer science and engineering as well as cognition and neurophilosophy.
The Centre de Recherches Médicales de Lambaréné (CERMEL) is an independent research institution in Lambaréné, Gabon. The center focuses on research into malaria, multi-resistant tuberculosis and worm infections. CERMEL maintains close ties with academic institutions all over the world, including the University of Tübingen, the Medical University of Vienna and the University of Amsterdam. President of CERMEL is the Austrian researcher Peter Gottfried Kremsner, also head of the Institute of Tropical Medicine at Tübingen University. General Secretary is the Gabonese researcher Ghyslain Mombo-Ngoma.
Jan Born is a neuroscientist who researches the role of sleep in memory consolidation, problem solving, and brain plasticity. He is Head of the Institute of Medical Psychology and the Behavioral Neurobiology department at the University of Tübingen.
Li Zhaoping, born in Shanghai, China, is a neuroscientist at the University of Tübingen in Germany. She is the only woman to win the first place in CUSPEA, an annual national physics competition in China, during CUSPEA's 10-year history (1979–1989). She proposed V1 Saliency Hypothesis (V1SH), and is the author of Understanding vision: theory, models, and data published by Oxford University Press.
Ingmar Malte Hoerr is a German biologist. He pioneered vaccinology research concerning the use of RNA and is a founder of the German biotechnology company CureVac. He created the initial technology used in RNA vaccines and has reportedly been nominated for a Nobel Prize. He is currently an Ambassador for the European Innovation Council for the years 2021–2027.
Fabian Kiessling is a German radiologist, university lecturer and author as well as a scientist in the field of molecular imaging.
Roland Josef Hardenberg is a German professor for Social and Cultural Anthropology. From 2009 to 2016 he was director of the Department of Ethnology at the Eberhard Karls University of Tübingen and from 2013 to 2017 deputy spokesperson of the CRC 1070 "ResourceCultures: Socio-cultural dynamics in the use of resources". In October 2016, he moved to a professorship for Social and Cultural Anthropology at the Goethe University Frankfurt am Main and took over as director of the Frobenius Institute in 2017. From 2017 to 2020, he was also managing director of the Institute for Ethnology at the Goethe University. Together with Holger Jebens he publishes the scientific journal Paideuma: Journal of Cultural Anthropology.
Open flow microperfusion (OFM) is a sampling method for clinical and preclinical drug development studies and biomarker research. OFM is designed for continuous sampling of analytes from the interstitial fluid (ISF) of various tissues. It provides direct access to the ISF by insertion of a small, minimally invasive, membrane-free probe with macroscopic openings. Thus, the entire biochemical information of the ISF becomes accessible regardless of the analyte's molecular size, protein-binding property or lipophilicity.
Katja Schenke-Layland is the Professor of Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine at the University of Tübingen. She is the Director of the Natural and Medical Sciences Institute at the University of Tübingen in Reutlingen (NMI), Study Dean of Medical Technologies at the University of Tübingen, and Founding Director of the Institute of Biomedical Engineering at the Medical Faculty of the University Tübingen. She is also the Founding Director of the 3R Center for In Vitro Models and Alternatives to Animal Testing Tübingen.
Dieter Oesterhelt was a German biochemist. From 1980 until 2008, he was director of the Max Planck Institute for Biochemistry, Martinsried.