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Bio Base Europe is an innovation and training center for the bio-based economy. It is a platform that supports the development of bio-based products such as bioplastics, biomaterials, bio-detergents, and bioenergy from renewable biomass resources. Its mission is to stimulate sustainable development and economic growth by facilitating R&D and training for bio-based process development. It consists of a Pilot Plant for the bio-based economy in the port of Ghent (Belgium) and a Training Center for the bio-based economy in Terneuzen (Netherlands).
On December 12, 2008, Europe, Flanders and the Netherlands allocated 21 million euros to the Interreg IV project Bio Base Europe. Bio Base Europe is the largest Interreg project ever granted to the Dutch-Flemish border region. The founding fathers are Ghent Bio-Energy Valley and Bio Park Terneuzen. [1] In 2009, Bio Base Europe was awarded the Sail of Papenburg prize for best innovative project by the Association of European Border Regions (AEBR). [2]
Bio Base Europe Pilot Plant is a pilot test facility for the bio-based economy built with the aim to close the gap between scientific feasibility and industrial application. It operates on multiple scales which allow the plant to host a range of equipment to scale up bio-based processes to industrial scale.
Tests done in the pilot plant aim to assess operating costs and other specific strengths and weaknesses of new processes before costly, large-scale investments in production plant facilities are made. Bio Base Europe Pilot Plant has no industrial shareholders and operates according to the open innovation service model. Companies and research centers throughout the world that are active in the bio-based economy can access these facilities for their technological developments. [3]
The processes done in the pilot plant can be divided into the following categories
1. Bio-refining: Biomass fractionation and pretreatment
2. Industrial biotechnology: Microorganisms and Enzymes
3. Green chemistry: Performed in Reactors
4. Downstream processing: Recovery of Products
In the bio-refining operations, biomass can be fractionated in its various parts. These operations involve A.O. milling and pulping, dispersion, homogenizing, physical separation such as centrifugation and decantation, filtration including dead end particulate filtration and cross flow membrane filtration. Biomass can also be pretreated prior to enzymatic hydrolysis, involving pulping and homogenization reactions, jet cooking, acid or alkaline treatment, steam explosion, etc.
White or industrial biotechnology processes involves the use of microorganisms and their enzymes in so-called fermentation processes or biocatalytic reactions. Fermentations can be performed from a 1 to 15,000-liter scale and involve both batches, fed batches or continuous operations. Reactors for enzymatic reactions are present that can be used with either water of organic solvents.
Green chemistry is performed in explosion proof installations such as glass-lined chemical reactors (1 - 6,000 L scale) that are suited to perform under vacuum or under pressure. The Bio Base Europe Pilot Plant is also equipped with filter dryers for solvent extraction of liquids and solids.
Downstream processing for the recovery of pure products after biochemical or chemical conversion involves utilizing various equipment for extraction, evaporation, demineralization, ion exchange, carbon treatment, crystallization, spray drying, lyophilization, etc.
Continuous process lines can be built up by connecting unit operations with mobile positive and centrifugal pumps, heat exchangers, dosing pumps, flexible and fixed piping and instrumentation.
The Bio Base Europe Training Center is an educational exhibition center promoting the development of a sustainable bio-based economy. It offers general and company-specific training and connects closely with the market demand. [4]
The Bio Base Europe Training Center works according to the one-stop-shop concept. The training center offers companies a wide range of trainings for their process operators and technical staff. For example, a training portfolio can be used by logging into a web-based learning management system. Furthermore, specific training and a full training program for technical staff are offered and support in hiring new process operators can be obtained. In addition, the Bio Base Europe Training Center is developing dynamic process simulators which can be used for the training of operators.
A bioreactor refers to any manufactured device or system that supports a biologically active environment. In one case, a bioreactor is a vessel in which a chemical process is carried out which involves organisms or biochemically active substances derived from such organisms. This process can either be aerobic or anaerobic. These bioreactors are commonly cylindrical, ranging in size from litres to cubic metres, and are often made of stainless steel. It may also refer to a device or system designed to grow cells or tissues in the context of cell culture. These devices are being developed for use in tissue engineering or biochemical/bioprocess engineering.
The Fischer–Tropsch process is a collection of chemical reactions that converts a mixture of carbon monoxide and hydrogen, known as syngas, into liquid hydrocarbons. These reactions occur in the presence of metal catalysts, typically at temperatures of 150–300 °C (302–572 °F) and pressures of one to several tens of atmospheres. The Fischer–Tropsch process is an important reaction in both coal liquefaction and gas to liquids technology for producing liquid hydrocarbons.
Cellulosic ethanol is ethanol produced from cellulose rather than from the plant's seeds or fruit. It can be produced from grasses, wood, algae, or other plants. It is generally discussed for use as a biofuel. The carbon dioxide that plants absorb as they grow offsets some of the carbon dioxide emitted when ethanol made from them is burned, so cellulosic ethanol fuel has the potential to have a lower carbon footprint than fossil fuels.
Anaerobic digestion is a sequence of processes by which microorganisms break down biodegradable material in the absence of oxygen. The process is used for industrial or domestic purposes to manage waste or to produce fuels. Much of the fermentation used industrially to produce food and drink products, as well as home fermentation, uses anaerobic digestion.
Industrial fermentation is the intentional use of fermentation in manufacturing processes. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. Commodity chemicals, such as acetic acid, citric acid, and ethanol are made by fermentation. Moreover, nearly all commercially produced industrial enzymes, such as lipase, invertase and rennet, are made by fermentation with genetically modified microbes. In some cases, production of biomass itself is the objective, as is the case for single-cell proteins, baker's yeast, and starter cultures for lactic acid bacteria used in cheesemaking.
In chemistry, fine chemicals are complex, single, pure chemical substances, produced in limited quantities in multipurpose plants by multistep batch chemical or biotechnological processes. They are described by exacting specifications, used for further processing within the chemical industry and sold for more than $10/kg. The class of fine chemicals is subdivided either on the basis of the added value, or the type of business transaction, namely standard or exclusive products.
Bioconversion, also known as biotransformation, is the conversion of organic materials, such as plant or animal waste, into usable products or energy sources by biological processes or agents, such as certain microorganisms. One example is the industrial production of cortisone, which one step is the bioconversion of progesterone to 11-alpha-Hydroxyprogesterone by Rhizopus nigricans. Another example is the bioconversion of glycerol to 1,3-propanediol, which is part of scientific research for many decades.
Waste-to-energy (WtE) or energy-from-waste (EfW) is the process of generating energy in the form of electricity and/or heat from the primary treatment of waste, or the processing of waste into a fuel source. WtE is a form of energy recovery. Most WtE processes generate electricity and/or heat directly through combustion, or produce a combustible fuel commodity, such as methane, methanol, ethanol or synthetic fuels.
The bioconversion of biomass to mixed alcohol fuels can be accomplished using the MixAlco process. Through bioconversion of biomass to a mixed alcohol fuel, more energy from the biomass will end up as liquid fuels than in converting biomass to ethanol by yeast fermentation.
Lignocellulose refers to plant dry matter (biomass), so called lignocellulosic biomass. It is the most abundantly available raw material on the Earth for the production of biofuels. It is composed of two kinds of carbohydrate polymers, cellulose and hemicellulose, and an aromatic-rich polymer called lignin. Any biomass rich in cellulose, hemicelluloses, and lignin are commonly referred to as lignocellulosic biomass. Each component has a distinct chemical behavior. Being a composite of three very different components makes the processing of lignocellulose challenging. The evolved resistance to degradation or even separation is referred to as recalcitrance. Overcoming this recalcitrance to produce useful, high value products requires a combination of heat, chemicals, enzymes, and microorganisms. These carbohydrate-containing polymers contain different sugar monomers and they are covalently bound to lignin.
Abengoa, S.A. was a Spanish multinational company in the green infrastructure, energy and water sectors. The company was founded in 1941 by Javier Benjumea Puigcerver and José Manuel Abaurre Fernández-Pasalagua, and was based in Seville, Spain. Its current chairman is Gonzalo Urquijo Fernández de Araoz. After repeated bankruptcies and rescues, it declared insolvency in February 2021 amid various regulatory and financial charges against the board and management, the second-largest corporate collapse in Spanish history.
Acetone–butanol–ethanol (ABE) fermentation, also known as the Weizmann process, is a process that uses bacterial fermentation to produce acetone, n-butanol, and ethanol from carbohydrates such as starch and glucose. It was developed by chemist Chaim Weizmann and was the primary process used to produce acetone, which was needed to make cordite, a substance essential for the British war industry during World War I.
Membrane bioreactors are combinations of some membrane processes like microfiltration or ultrafiltration with a biological wastewater treatment process, the activated sludge process. These technologies are now widely used for municipal and industrial wastewater treatment. The two basic membrane bioreactor configurations are the submerged membrane bioreactor and the side stream membrane bioreactor. In the submerged configuration, the membrane is located inside the biological reactor and submerged in the wastewater, while in a side stream membrane bioreactor, the membrane is located outside the reactor as an additional step after biological treatment.
Bioproducts or bio-based products are materials, chemicals and energy derived from renewable biological material.
Chemical process miniaturization refers to a philosophical concept within the discipline of process design that challenges the notion of "economy of scale" or "bigger is better". In this context, process design refers to the discipline taught primarily to chemical engineers. However, the emerging discipline of process miniaturization will involve integrated knowledge from many areas; as examples, systems engineering and design, remote measurement and control using intelligent sensors, biological process systems engineering, and advanced manufacturing robotics, etc.
In industrial paper-making processes, organosolv is a pulping technique that uses an organic solvent to solubilise lignin and hemicellulose. It has been considered in the context of both pulp and paper manufacture and biorefining for subsequent conversion of cellulose to fuel ethanol. The process was invented by Theodor Kleinert in 1968 as an environmentally benign alternative to kraft pulping.
Single cell oil, also known as Microbial oil consists of the intracellular storage lipids, triacyglycerols. It is similar to vegetable oil, another biologically produced oil. They are produced by oleaginous microorganisms, which is the term for those bacteria, molds, algae and yeast, which can accumulate 20% to 80% lipids of their biomass. The accumulation of lipids take place by the end of logarithmic phase and continues during station phase until carbon source begins to reduce with nutrition limitation.
Biomanufacturing is a type of manufacturing or biotechnology that utilizes biological systems to produce commercially important biomaterials and biomolecules for use in medicines, food and beverage processing, and industrial applications. Biomanufacturing products are recovered from natural sources, such as blood, or from cultures of microbes, animal cells, or plant cells grown in specialized equipment. The cells used during the production may have been naturally occurring or derived using genetic engineering techniques.
Inbicon is a Danish company that produces cellulosic ethanol.
Cellulosic sugars are derived from non-food biomass (e.g. wood, agricultural residues, municipal solid waste). The biomass is primarily composed of carbohydrate polymers cellulose, hemicellulose, and an aromatic polymer (lignin). The hemicellulose is a polymer of mainly five-carbon sugars C5H10O5 (xylose). and the cellulose is a polymer of six-carbon sugar C6H12O6 (glucose). Cellulose fibers are considered to be a plant’s structural building blocks and are tightly bound to lignin, but the biomass can be deconstructed using Acid hydrolysis, enzymatic hydrolysis, organosolv dissolution, autohydrolysis or supercritical hydrolysis. A more recent mechanical method offers hope that at last, a more economic and waste free method has been found although it is still to scale and is not yet commercial.