The Both respirator, also known as the Both Portable Cabinet Respirator, was a negative pressure ventilator (more commonly known as an "iron lung") invented by Edward Both in 1937. Made from plywood, the respirator was an affordable alternative to the more expensive designs that had been used prior to its development, and accordingly came into common usage in Australia. More widespread use emerged during the 1940s and 1950s, when the Both respirator was offered free of charge to Commonwealth hospitals by William Morris.
In 1937, Australia faced a poliomyelitis (polio) epidemic. [1] At the time, iron lungs provided one of the main methods of treating the "paralytic breathing failures" that were a complication of the illness. Although tank respirators had been developed earlier, the iron lung itself was still fairly new, having been designed by Philip Drinker and Louis Agassiz Shaw in 1928. [2] Their design, which became known as a "Drinker's" or, due to its construction, an "iron lung", proved to be an effective means of prolonging the life of patients with poliomyelitis – although the first person to be treated in the ventilator died after two days from cardiac failure possibly related to pneumonia, the second patient recovered after spending two weeks in the machine. [3] However in Australia, the widespread use of the Drinkers was hampered by a number of factors, most notably cost, the heavy weight of the device, and the need to ship the device to the United States for servicing, and thus there were few of the devices in the country. [1]
Adelaide inventor Edward Both was approached in the hope that he could provide an alternative to meet the demand brought on by the epidemic. Both ran Both Equipment Limited with his brother Donald, and had previously developed medical apparatus. It took a few weeks for the pair to create their own iron lung, which they named the "Both portable cabinet respirator". Unlike the Drinker's machine, the Both respirator was made from plywood (even though it continued to be referred to as an "iron" lung), and this both kept the price down and made it more portable. The Both device cost only £100, was portable due to its light weight and the addition of wheels, and was simple enough that hospitals could build their own in their workshops, and it soon proved to be a success. [1] The portability also opened up other possibilities, and as a result people who needed extended assistance from the device were able to use one in their private residences: indeed, in 2003 there were still five privately owned Both respirators being used in residences within Victoria. [1] [4]
In 1938, Edward Both traveled to England to sell an electrocardiograph which he had invented. [1] While there, he heard over BBC Radio a request for an iron lung to help treat a young patient residing in a country hospital. [5] Responding to the call, Both hired a workshop and assembled one of his designs within 24 hours, and the Both respirator was able to quickly gain the approval of the London County Council. Subsequently, he built more of the respirators during his stay, and one was sent to the Nuffield Department of Anaesthetics at the Radcliffe Infirmary where a short film was made of the device. This film was subsequently shown to William Morris (Lord Nuffield) by Robert Macintosh, the department's Professor. Nuffield was the manufacturer of the Morris motor car as well as a philanthropist. [1]
Nuffield was taken by the design, and in November of that year he offered to turn over part of his car factory for the manufacture of the Both respirators and to provide the respirators free of charge to any hospital in the Commonwealth that requested one. [1] In spite of some initial opposition – Nuffield was criticized in the British Medical Journal by Frederick Menzies for using a design before the iron lung had been perfected, and for supplying it to hospitals which may lack the knowledge as to how to employ it [6] – over 1,700 Both–Nuffield respirators were distributed to hospitals. [1] By the early 1950s there were over 700 Both–Nuffield iron lungs in the United Kingdom, compared with only 50 Drinker's models. [7]
A ventilator is a type of breathing apparatus, a class of medical technology that provides mechanical ventilation by moving breathable air into and out of the lungs, to deliver breaths to a patient who is physically unable to breathe, or breathing insufficiently. Ventilators may be computerized microprocessor-controlled machines, but patients can also be ventilated with a simple, hand-operated bag valve mask. Ventilators are chiefly used in intensive-care medicine, home care, and emergency medicine and in anesthesiology.
Mechanical ventilation or assisted ventilation is the medical term for using a machine called a ventilator to fully or partially provide artificial ventilation. Mechanical ventilation helps move air into and out of the lungs, with the main goal of helping the delivery of oxygen and removal of carbon dioxide. Mechanical ventilation is used for many reasons, including to protect the airway due to mechanical or neurologic cause, to ensure adequate oxygenation, or to remove excess carbon dioxide from the lungs. Various healthcare providers are involved with the use of mechanical ventilation and people who require ventilators are typically monitored in an intensive care unit.
Intensive care medicine, also called critical care medicine, is a medical specialty that deals with seriously or critically ill patients who have, are at risk of, or are recovering from conditions that may be life-threatening. It includes providing life support, invasive monitoring techniques, resuscitation, and end-of-life care. Doctors in this specialty are often called intensive care physicians, critical care physicians, or intensivists.
An iron lung is a type of negative pressure ventilator (NPV), a mechanical respirator which encloses most of a person's body and varies the air pressure in the enclosed space to stimulate breathing. It assists breathing when muscle control is lost, or the work of breathing exceeds the person's ability. Need for this treatment may result from diseases including polio and botulism and certain poisons.
Extracorporeal membrane oxygenation (ECMO), is a form of extracorporeal life support, providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to provide an adequate amount of oxygen, gas exchange or blood supply (perfusion) to sustain life. The technology for ECMO is largely derived from cardiopulmonary bypass, which provides shorter-term support with arrested native circulation. The device used is a membrane oxygenator, also known as an artificial lung.
A breathing apparatus or breathing set is equipment which allows a person to breathe in a hostile environment where breathing would otherwise be impossible, difficult, harmful, or hazardous, or assists a person to breathe. A respirator, medical ventilator, or resuscitator may also be considered to be breathing apparatus. Equipment that supplies or recycles breathing gas other than ambient air in a space used by several people is usually referred to as being part of a life-support system, and a life-support system for one person may include breathing apparatus, when the breathing gas is specifically supplied to the user rather than to the enclosure in which the user is the occupant.
Ventilator-associated pneumonia (VAP) is a type of lung infection that occurs in people who are on mechanical ventilation breathing machines in hospitals. As such, VAP typically affects critically ill persons that are in an intensive care unit (ICU) and have been on a mechanical ventilator for at least 48 hours. VAP is a major source of increased illness and death. Persons with VAP have increased lengths of ICU hospitalization and have up to a 20–30% death rate. The diagnosis of VAP varies among hospitals and providers but usually requires a new infiltrate on chest x-ray plus two or more other factors. These factors include temperatures of >38 °C or <36 °C, a white blood cell count of >12 × 109/ml, purulent secretions from the airways in the lung, and/or reduction in gas exchange.
John Haven Emerson was an American inventor of biomedical devices, specializing in respiratory equipment. He is perhaps best remembered for his work in improving the iron lung.
Continuous positive airway pressure (CPAP) is a form of positive airway pressure (PAP) ventilation in which a constant level of pressure greater than atmospheric pressure is continuously applied to the upper respiratory tract of a person. The application of positive pressure may be intended to prevent upper airway collapse, as occurs in obstructive sleep apnea, or to reduce the work of breathing in conditions such as acute decompensated heart failure. CPAP therapy is highly effective for managing obstructive sleep apnea. Compliance and acceptance of use of CPAP therapy can be a limiting factor, with 8% of people stopping use after the first night and 50% within the first year.
The history of polio (poliomyelitis) infections began during prehistory. Although major polio epidemics were unknown before the 20th century, the disease has caused paralysis and death for much of human history. Over millennia, polio survived quietly as an endemic pathogen until the 1900s when major epidemics began to occur in Europe. Soon after, widespread epidemics appeared in the rest of the world. By 1910, frequent epidemics became regular events throughout the developed world primarily in cities during the summer months. At its peak in the 1940s and 1950s, polio would paralyze or kill over half a million people worldwide every year.
Fairfield Infectious Diseases Hospital, originally known as Queens Memorial Infectious Diseases Hospital, operated from 1904 to its closure in 1996. Perched high on the banks of the Yarra River at Yarra Bend in the inner Melbourne suburb of Fairfield, it developed an international reputation for the research and treatment of infectious diseases. When it closed, it was the last specific infectious diseases hospital in Australia.
Edward Thomas Both, OBE was an Australian inventor credited with the development of a number of medical, military and general-purpose inventions. These included a low-cost "iron lung", a humidicrib, the first portable electrocardiograph and the "visitel" – a forerunner to the modern fax machine. His inventions gained him an OBE in 1940, and his work led to Both being given the moniker of the "Edison of Australia".
Bjørn Aage Ibsen was a Danish anesthetist and founder of intensive-care medicine.
Modes of mechanical ventilation are one of the most important aspects of the usage of mechanical ventilation. The mode refers to the method of inspiratory support. In general, mode selection is based on clinician familiarity and institutional preferences, since there is a paucity of evidence indicating that the mode affects clinical outcome. The most frequently used forms of volume-limited mechanical ventilation are intermittent mandatory ventilation (IMV) and continuous mandatory ventilation (CMV). There have been substantial changes in the nomenclature of mechanical ventilation over the years, but more recently it has become standardized by many respirology and pulmonology groups. Writing a mode is most proper in all capital letters with a dash between the control variable and the strategy.
A negative pressure ventilator (NPV) is a type of mechanical ventilator that stimulates an ill person's breathing by periodically applying negative air pressure to their body to expand and contract the chest cavity.
The Bragg-Paul Pulsator, also known as the Bragg-Paul respirator, was a non-invasive medical ventilator invented by William Henry Bragg and designed by Robert W. Paul in 1933 for patients unable to breathe for themselves due to illness.
An open-source ventilator is a disaster-situation ventilator made using a freely licensed (open-source) design, and ideally, freely available components and parts. Designs, components, and parts may be anywhere from completely reverse-engineered or completely new creations, components may be adaptations of various inexpensive existing products, and special hard-to-find and/or expensive parts may be 3D-printed instead of purchased. As of early 2020, the levels of documentation and testing of open-source ventilators was well below scientific and medical-grade standards.
Carl Gunnar David Engström was a Swedish physician and innovator. He is the inventor of the first intermittent positive pressure mechanical ventilator that could deliver breaths of controllable volume and frequency and also deliver inhalation anesthetics.
A breathing apparatus or breathing set is equipment which allows a person to breathe in a hostile environment where breathing would otherwise be impossible, difficult, harmful, or hazardous, or assists a person to breathe. A respirator, medical ventilator, or resuscitator may also be considered to be breathing apparatus. Equipment that supplies or recycles breathing gas other than ambient air in a space used by several people is usually referred to as being part of a life-support system, and a life-support system for one person may include breathing apparatus, when the breathing gas is specifically supplied to the user rather than to the enclosure in which the user is the occupant.