Brenda Gallie | |
---|---|
Spouse | Michael Jewett |
Academic background | |
Education | MD, 1969, Queen's University at Kingston |
Academic work | |
Institutions | Sick Kids Hospital |
Main interests | Retinoblastoma |
Brenda Louise Gallie CM OOnt is a Canadian ophthalmologist. She is the Head of the Retinoblastoma Program in the Hospital for Sick Children (Toronto) Department of Ophthalmology and Vision Sciences.
Gallie completed her medical degree at Queen's University at Kingston in 1969. Following this,she completed her residency and fellowship training at the University of Toronto and a second research fellowship in Immunology and Cancer at the Memorial Sloan-Kettering Cancer Center. [1]
Upon completing her fellowships,Gallie joined Sick Kids Hospital where she made numerous discoveries about the cancer retinoblastoma. [1] In January 1988,Gallie collaborated with Drs. Robert Phillips and Andy Becker to set up a Retinoblastoma Group in Toronto. [2] This eventually led to the discovery of a new therapy for retinoblastoma. [3] She discovered the fundamental principles of tumor suppressor genes and developed a new methodology to identify the RB1 gene. [1] These tests accurately identified children at risk of developing retinoblastoma before they are born. [4] In 1999,following the discovery of academic misconduct by Gideon Koren,Gallie moved her laboratory to Princess Margaret Hospital. She then opened her laboratory at Toronto Western Hospital a year later. [5] By 2006,Gallie put forward a National Strategy to optimize care for retinoblastoma in Canada. She was also named a Member of the Order of Ontario for being an expert in the treatment of retinoblastoma and contributing to the health care of Canadians. [4]
In 2013,Gallie led a research team that discovered a new and potentially less life-threatening form of retinoblastoma. [6] The following year,Gallie was named a Member of the Order of Canada for her "contributions to the prevention,diagnosis and treatment of retinoblastoma,a childhood eye cancer." [7] She was also recognized with the 2018 Helen Keller Prize for Vision Research [8] and the 2019 Collaborative Leadership Research Grant from the non-profit Uplifting Athletes. [9]
Gallie is married to urologist Michael Jewett. [10]
Sir Frederick Grant Banting was a Canadian medical scientist,physician,painter,and Nobel laureate noted as the co-discoverer of insulin and its therapeutic potential.
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina,the light-detecting tissue of the eye. It is the most common primary malignant intraocular cancer in children,and it is almost exclusively found in young children.
The Temerty Faculty of Medicine is the medical school of the University of Toronto. Founded in 1843,the faculty is based in Downtown Toronto and is one of Canada's oldest institutions of medical studies,being known for the discovery of insulin,stem cells and the site of the first single and double lung transplants in the world.
Tak Wah Mak,is a Canadian medical researcher,geneticist,oncologist,and biochemist. He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology. In 1995,Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4,thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment. Mak is also the founder of Agios Pharmaceuticals,whose lead compound,IDHIFA®,was approved by the FDA for acute myeloid leukemia in August 2017,becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment. He has worked in a variety of areas including biochemistry,immunology,and cancer genetics.
Robert A. Phillips is a Canadian scientist,with a long-term interest in cancer research,and special interests in blood cell development and in retinoblastoma,an inherited eye tumour in children. His expertise has spanned the breadth of disciplines including radiation biology,cellular and molecular biology,immunology and molecular genetics.
Janet Rossant,is a developmental biologist well known for her contributions to the understanding of the role of genes in embryo development. She is a world renowned leader in developmental biology. Her current research interests focus on stem cells,molecular genetics,and developmental biology. Specifically,she uses cellular and genetic manipulation techniques to study how genes control both normal and abnormal development of early mouse embryos. Rossant has discovered information on embryo development,how multiple types of stem cells are established,and the mechanisms by which genes control development. In 1998,her work helped lead to the discovery of the trophoblast stem cell,which has assisted in showing how congenital anomalies in the heart,blood vessels,and placenta can occur.
Vesanto Melina is a Canadian Registered Dietitian and co-author of books that have become classics in the field of vegetarian,vegan,and raw foods nutrition,have sold almost a million copies in English and are in nine additional languages. She has presented talks and workshops on various aspects of vegetarian,vegan and raw foods and nutrition for dietitians,health professionals,and vegetarian associations in 17 American states and 9 Canadian provinces,and in 10 countries.
The Krembil Research Institute,formerly known as the Toronto Western Research Institute,is an academic medical research institute in Toronto. It is one of the largest research institutes in Canada focusing on human neurological disease.
Emily Ying Chew,M.D.,is an American ophthalmologist and an expert on the human retina with a strong clinical and research interest in diabetic eye disease and age-related eye diseases. She currently works for the National Eye Institute (NEI) at the National Institutes of Health (NIH) in Bethesda,Maryland,where she serves as deputy director of the Division of Epidemiology and Clinical Applications (DECA) and the Institute's deputy clinical director. She designs and implements Phase 1,2 and 3 clinical trials at the NIH Clinical Center. Chew is board certified in ophthalmology.
J. William Harbour,M.D.,is an American ophthalmologist,ocular oncologist and cancer researcher. He is currently Chair of the Department of Ophthalmology at the University of Texas Southwestern Medical Center in Dallas. He previously served as the vice chair and director of ocular oncology at the Bascom Palmer Eye Institute and associate director for basic science at the Sylvester Comprehensive Cancer Center of the University of Miami's Miller School of Medicine.
Judith Eve Kingston was an English paediatric oncologist best known for pioneering the use of chemotherapy in the treatment of the retinoblastoma form of cancer.
Jessie Catherine Gray was a Canadian cancer surgeon,educator,and researcher. Known as the Canadian "First Lady of Surgery",Gray is described as a trailblazer for women surgeons and an example that women could excel in the male-dominated field of general surgery. During her career,she was considered one of the top four cancer surgeons in North America,and she earned many firsts and fellowships in her field.
Gillian Elizabeth Wu is a Canadian Immunologist and the former Dean of Pure and Applied Science at York University. She is currently Professor Emerita in York University's Faculty of Science and Faculty of Health and also at the University of Toronto Faculty of Medicine.
Batsheva Kerem,is an Israeli geneticist who was on the research team that identified and cloned the CFTR gene,which when mutated,is responsible for causing cystic fibrosis (CF). She later established the Israel National Center for CF Genetic Research. She discovered the most prevalent cystic fibrosis-causing mutations among the Israeli population,allowing for the establishment of nationwide genetic screening programs to identify carriers of these mutations and enabling prenatal diagnoses. She researches how some CF mutations prevent CFTR protein production by causing nonsense-mediated decay and abnormal mRNA splicing,and how therapies might be able to counteract those problems. She also studies the role of genetic instability in cancer. She is currently a professor at the Hebrew University.
Marjorie Ileen Davis was a Canadian physician and surgeon. Davis became a Fellow of the Royal College of Surgeons of Canada in 1947 and was the Chief of Surgery at Toronto’s Women's College Hospital from 1965 to 1976.
Rulan S. Parekh is an American-Canadian clinician-scientist and nephrologist. She is the vice president of research,education and innovation at Women's College Hospital and former senior scientist in Child Health Evaluative Sciences and Associate Chief of Clinical Research at SickKids.
Simone Natalie Vigod is a Canadian scientist,Head of the Department of Psychiatry at Women's College Hospital and Professor in the Department of Psychiatry at the University of Toronto in Toronto,Ontario,Canada. She focuses her research on perinatal mood disorders and has conducted some of the largest studies worldwide on maternal mental illness around the time of pregnancy.
Monica J. Justice is an American–Canadian developmental geneticist. She is the Canada Research Chair in Mammalian Molecular Genetics at the University of Toronto and Program Head of Genetics and Genome Biology at SickKids Hospital.
Gladys Lillian Boyd was a Canadian paediatrician at the Hospital for Sick Children in Toronto. She was a pioneer in the treatment of juvenile diabetes. A collaborator of Sir Frederick Banting,she was one of the first physicians to treat diabetic children with insulin.
Jeffrey L. Wrana is a Canadian cancer researcher. He is the CIBC Breast Cancer Research Scientist and Mary Janigan Research Chair in Molecular Cancer Therapeutic at Mount Sinai Hospital and University of Toronto. As a Tier 1 Canada Research Chair in Medical Genetics and Microbiology at U of T,Wrana was elected a Fellow of the Royal Society of Canada.