Bruce Hammock | |
---|---|
Born | August 13, 1947 Little Rock, Arkansas |
Alma mater | Louisiana State University University of California, Berkeley |
Known for | insect physiology enzymology toxicology pharmacology experimental therapeutics immunoassay development |
Scientific career | |
Fields | Entomology-Toxicology, Zoology, Chemistry |
Institutions | Northwestern University University of California, Davis University of California, Riverside |
Website | https://www.biopestlab.ucdavis.edu/home |
Dr. Bruce Hammock is an American entomologist, chemist and toxicologist. He is known for his research regarding improving pest control agents, monitoring and determining the human and environmental health effects of pesticides and in medicine work on the inflammation resolving branch of the arachidonate cascade leading to a drug candidate to treat pain and inflammatory disease. Additionally, he made many advances in U.S. agriculture which led to him receiving the Frasch and Spencer Awards of the ACS and the Alexander von Humboldt Award in Agriculture. His early work tested the basic hypothesis in both insects and mammals that regulation of chemical mediators could be as much by specific degradation as by biosynthesis. He exploited this fundamental knowledge both in agriculture and in human pharmacology.
In 1980, Hammock joined the University of California, Davis as an associate professor of Entomology and Environmental Toxicology. Since then, he has become a crucial part of campus by taking on roles such as being an active member of the UC Davis Comprehensive Cancer Center, principal investigator of the Biotechnology Training grant for 15 years and the program director of the NIEHS UC Davis Superfund Basic Research Program for the past 35 years. [1]
Bruce D. Hammock was born on August 13, 1947, in Little Rock, Arkansas where he attended high school. [2] His father was a postal worker and his mother sold encyclopedias. [2] As a young boy, he developed a love of natural history in part through Boy Scouts and enjoyed studying and befriending creatures in the nearby forest, including a pet raccoon named "Willy". [2]
Hammock attended Louisiana State University in Baton Rouge starting in forestry but moving to entomology, obtaining a B.S. magna cum laude in Entomology (with minors in Zoology and Chemistry) in 1969. [2] [3] He also obtained a PhD in Entomology-Toxicology at UC Berkeley in 1973 studying with John Casida. [3] [2] He then went on active duty as a medical officer at the U.S. Army Academy of Health Sciences where he developed a lifelong interest in controlling pain and inflammation. [4] He became a Rockefeller Postdoctoral Fellow in Biochemistry at Northwestern University in 1974. [5] Starting in 1975, he held his first academic position at UC Riverside for five years, then later became a professor at UC Davis in 1980, where he taught biochemistry, endocrinology, toxicology, and pharmaceutical discovery and development. [5] [3] [6] For decades he also taught mountaineering and whitewater kayaking through the UCD Outdoor Adventures program, and started the institutionalization of annual water balloon fights, better known as "Bruce's Big Balloon Battle at Briggs". [2] [7] [8]
Hammock married Lassie May Graham of Fresno. They have three children Thomas S., Bruce G. and Frances H. Hammock and have two grandchildren Max and Lelia Lona.
Throughout his career, Dr. Hammock explored diverse research areas including insect physiology, toxicology, pharmacology, and experimental therapeutics. [9] In his Ph.D. he studied both basic insect developmental biology and the development of ‘green pesticides’ based on insect hormones. It was here he developed the hypothesis that degradation of chemical mediators was important in physiology. In insects this led to the development of recombinant viral insecticides and in mammals to a new target for control of pain and inflammation in man and companion animals. At UC Riverside he continued the above work and also pioneered the use of immunoassays for monitoring human and environmental exposure to pesticides and remains a leader in the field. [10] [11]
Dr. Hammock continually moves between fundamental research and its application. Amongst his many research endeavors, he found a key hydrolytic enzyme that controlled insect metamorphosis and exploited this by developing transition state inhibitors that altered insect development. [12] Then he used this hydrolytic enzyme in a transgenic viral insecticide. [13] He found another hydrolytic enzyme important in insect development that also controlled key biological functions in mammals. His laboratory developed transition state inhibitors of this enzyme as well, which are used in human clinical trials where they reduce pain and inflammation. [2] [14] In addition, his lab pioneered immunoassay techniques for analyzing both humans and environmental exposure to pesticides and other contaminants. [15] He continues as an internationally recognized figure in these fields for over five decades and has published over 1300 papers. [16]
From 1986 to 1987, Dr. Hammock served as the Pharmacology and Toxicology Graduate Group Chair in UC Davis. [9] In 1987, Dr. Hammock became the director of the Nation's first Superfund Research Program at UC Davis and ran the program for over 35 years. This is a fund that supports interdisciplinary scientists in finding solutions to complex health and environmental issues caused by hazardous waste contamination. [1] For 14 years he ran a NIH Training Grant in Biotechnology at UC Davis for cross training in physical and biological sciences. He was also one of the founding members of the UC Davis Medical School Comprehensive Cancer Center, which started in 1991. [17] From 2002 to 2016, Dr. Hammock served as the director of the UC Davis's National Institute of Health Biotechnology Training Program and the National Institute of Environmental Health Sciences Combined Analytical Laboratory at UC Davis. [18] He was one of the founding board members of UCDMC's Center for Pain Relief [9] — members of Dr. Hammock founded three companies: Synthia (2015) to assist students and postgraduates with technology transfer, Arete Therapeutics (2003), and EicOsis (2011) in pharmaceutical development to move soluble epoxide hydrolase inhibitors into the clinic. [19]
Pesticides are substances that are meant to control pests. This includes herbicide, insecticide, nematicide, molluscicide, piscicide, avicide, rodenticide, bactericide, insect repellent, animal repellent, microbicide, fungicide, and lampricide. The most common of these are herbicides, which account for approximately 50% of all pesticide use globally. Most pesticides are intended to serve as plant protection products, which in general, protect plants from weeds, fungi, or insects. As an example, the fungus Alternaria solani is used to combat the aquatic weed Salvinia.
Piperonyl butoxide (PBO) is a pale yellow to light brown liquid organic compound used as a synergist component of pesticide formulations. That is, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone. It is a semisynthetic derivative of safrole.
N,N-Diethyl-meta-toluamide, also called diethyltoluamide or DEET, is the oldest, most effective and most common active ingredient in commercial insect repellents. It is a slightly yellow oil intended to be applied to the skin or to clothing and provides protection against mosquitoes, flies, ticks, fleas, chiggers, leeches, and many other biting insects.
Bruce Nathan Ames is an American biochemist. He is a professor of Biochemistry and Molecular Biology Emeritus at the University of California, Berkeley, and was a senior scientist at Children's Hospital Oakland Research Institute (CHORI). He is the inventor of the Ames test, a system for easily and cheaply testing the mutagenicity of compounds.
In organic chemistry, organophosphates are a class of organophosphorus compounds with the general structure O=P(OR)3, a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid.
Dichlorvos is an organophosphate widely used as an insecticide to control household pests, in public health, and protecting stored products from insects. The compound has been commercially available since 1961 and has become controversial because of its prevalence in urban waterways and the fact that its toxicity extends well beyond insects. Since 1988, dichlorvos cannot be used as a plant protection product in the EU.
John Edward Casida was an American entomologist, toxicologist and professor at the University of California, Berkeley.
Lynn Kimsey is an entomologist, taxonomist, director of the Bohart Museum of Entomology and professor of entomology at the University of California, Davis since 1989. Her specialties are bees and wasps; and insect diversity and evolution.
The Bohart Museum of Entomology was founded in 1946 on the campus of the University of California, Davis. The museum is currently the seventh largest insect collection in North America with more than seven million specimens of terrestrial and freshwater arthropods. At least 90% of these holdings are insects. The collection is worldwide in scope with the Western Hemisphere, Indonesia, and Australasia particularly well represented.
Robert Lee Metcalf was an American entomologist, environmental toxicologist, and insect chemical ecologist. Metcalf was noted for making environmentally safe pest control achievable.
Ray Fred Smith was an American agronomist and entomologist whose research focused on biological methods of arthropod pest management. He was a chair of the Entomology Department at the University of California at Berkeley from 1959 to 1973. He was an editor of the Annual Review of Entomology from 1960 to 1977.
Walter Soares Leal is a Brazilian biochemist and entomologist who is known for identifying pheromones and mosquito attractants, and elucidating a mechanism of action of the insect repellent DEET.
Sharon Y. Strauss is an American evolutionary ecologist. She is a Professor of Evolution and Ecology at the University of California, Davis.
John Maurice Tucker was an American botanist, herbarium director, and leading expert on oak taxonomy.
M. Saif Islam is a Bangladeshi-American engineering professor of Electrical and Computer Engineering at the University of California, Davis.
Thomas Wallace Scott is an American tropical infectious disease epidemiologist.
Neal Mikkelsen Williams is an American pollination ecologist.
Myron P. Zalucki is an Australian professor emeritus of entomology at the University of Queensland (UQ). Zalucki is a Fellow of the Entomological Society of America, a member and secretary of the Council of the International Congresses of Entomology, and a co-editor of the Annual Review of Entomology.
Mary Foley Benson was an American scientific illustrator and fine artist. She specialized in detailed, realistic watercolor paintings of plants and insects.
Jennifer S. Thaler is an American entomologist who is a faculty member in the Department of Entomology, with a joint appointment in the Department of Ecology and Evolutionary Biology, at Cornell University in Ithaca, New York. She has expertise in the areas of population and community ecology, plant-insect interactions, tri-trophic interactions, and chemical ecology.