C5orf45

Last updated

Chromosome 5 open reading frame 45 is a protein that in humans is encoded by the C5orf45 gene. [1] The orthologue in mice is 3010026O09Rik. [1]

Contents

Model organisms

Model organisms have been used in the study of C5orf45 function. A conditional knockout mouse line, called 3010026O09Riktm1a(EUCOMM)Wtsi [6] [7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. [8] [9] [10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. [4] [11] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: male homozygote mutants were infertile. [4]

Related Research Articles

<span class="mw-page-title-main">TRPC4AP</span> Protein-coding gene in the species Homo sapiens

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

<span class="mw-page-title-main">PDS5B</span> Protein-coding gene in the species Homo sapiens

Sister chromatid cohesion protein PDS5 homolog B(PDS5B) is a protein that in humans is encoded by the PDS5B gene. It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.

<span class="mw-page-title-main">CDS2</span> Protein-coding gene in the species Homo sapiens

Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene.

<span class="mw-page-title-main">COQ9</span> Protein-coding gene in humans

Ubiquinone biosynthesis protein COQ9, mitochondrial, also known as coenzyme Q9 homolog (COQ9), is a protein that in humans is encoded by the COQ9 gene.

<span class="mw-page-title-main">FAM134C</span> Protein-coding gene in the species Homo sapiens

Protein FAM134C is a protein that in humans is encoded by the FAM134C gene.

<span class="mw-page-title-main">TRIM45</span> Protein-coding gene in the species Homo sapiens

tripartite motif containing 45, also known as TRIM45, is a human gene.

<span class="mw-page-title-main">DCTN5</span> Protein-coding gene in the species Homo sapiens

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.

<span class="mw-page-title-main">MDN1</span> Protein-coding gene in the species Homo sapiens

MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene. Midasin is a member AAA ATPase family.

<span class="mw-page-title-main">CCDC137</span> Protein found in humans

Coiled-coil domain containing 137 is a protein that in humans is encoded by the CCDC137 gene.

<span class="mw-page-title-main">NOM1</span> Protein-coding gene in the species Homo sapiens

Nucleolar protein with MIF4G domain 1 is a protein that in humans is encoded by the NOM1 gene.

<span class="mw-page-title-main">SLC41A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene.

<span class="mw-page-title-main">PLD5</span> Protein-coding gene in the species Homo sapiens

Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene.

<span class="mw-page-title-main">DIP2B</span> Protein-coding gene in the species Homo sapiens

DIP2 disco-interacting protein 2 homolog B (Drosophila) is a protein that in humans is encoded by the DIP2B gene. A member of the disco-interacting protein homolog 2 protein family, it contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1, as well as AMP-binding sites. The presence of these sites suggests that DIP2B may participate in DNA methylation. This gene is located near a folate-sensitive fragile site.

FK506 binding protein 7 is a protein that in humans is encoded by the FKBP7 gene. The gene is also known as FKBP23 and PPIase. FKBP7 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. The orthologous protein in mouse is located in the endoplasmic reticulum and binds calcium.

RAB7, member RAS oncogene family-like 1 is a protein that in humans is encoded by the RAB7L1 gene. The gene is also known as RAB7L. RAB7L1 encodes a small GTP-binding protein and is a member of the Ras superfamily.

Glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial) is a protein that in humans is encoded by the GATC gene. The gene is also known as 15E1.2 and encodes part of a Glu-tRNA(Gln) amidotransferase enzyme.

Family with sequence similarity 104, member A is a protein that in humans is encoded by the FAM104A gene. The orthologous gene in mice is also known as D11Wsu99e.

<span class="mw-page-title-main">C1orf38</span> Protein-coding gene in the species Homo sapiens

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene. The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712. C1orf38 has been associated with cancer susceptibility.

<span class="mw-page-title-main">C2orf54</span> Protein-coding gene in the species Homo sapiens

Chromosome 2 open reading frame 54, otherwise known as Mab21L4, is a protein that in humans is encoded by the C2orf54 gene. The orthologue in mice is 2310007B03Rik.

Chromosome 9 open reading frame 156 is a protein that in humans is encoded by the C9orf156 gene. The gene is also known as NAP1 and HSPC219; the orthologue in mice is 5830415F09Rik.

References

  1. 1 2 "Chromosome 5 open reading frame 45" . Retrieved 2011-12-07.
  2. "Salmonella infection data for 3010026O09Rik". Wellcome Trust Sanger Institute.
  3. "Citrobacter infection data for 3010026O09Rik". Wellcome Trust Sanger Institute.
  4. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
  5. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. "International Knockout Mouse Consortium".[ permanent dead link ]
  7. "Mouse Genome Informatics".
  8. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
  9. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID   21677718.
  10. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
  11. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi: 10.1186/gb-2011-12-6-224 . PMC   3218837 . PMID   21722353.

Further reading