C8 (NAMPT activator)

Last updated

C8
C8 structure.png
Clinical data
Drug class NAMPT activator
Identifiers
  • 1-[4-[(2,5-difluorophenyl)methylsulfamoyl]phenyl]-3-(pyridin-4-ylmethyl)urea
PubChem CID
ChemSpider
Chemical and physical data
Formula C20H18F2N4O3S
Molar mass 432.45 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1NC(=O)NCC2=CC=NC=C2)S(=O)(=O)NCC3=C(C=CC(=C3)F)F
  • InChI=1S/C20H18F2N4O3S/c21-16-1-6-19(22)15(11-16)13-25-30(28,29)18-4-2-17(3-5-18)26-20(27)24-12-14-7-9-23-10-8-14/h1-11,25H,12-13H2,(H2,24,26,27)
  • Key:QCDUEYXOVLJGAR-UHFFFAOYSA-N

C8 (NAMPT activator 5), is a drug which acts as a selective activator of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). It increases the rate of nicotinamide mononucleotide production by NAMPT and shows anti-aging effects in model organisms such as Caenorhabditis elegans and mice. [1]

See also

References

  1. ↑ Yang S, Sun D, Wu Y, Chen S, Guo Y, Li J, et al. (March 2024). "Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions". Journal of Medicinal Chemistry. 67 (5): 4120–4130. doi:10.1021/acs.jmedchem.3c02370. PMID   38367219.
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