Coiled-Coil Domain Containing 11, also known as CCDC11 is a protein, that is encoded by CCDC11 gene located at chromosome 18 in humans. [1]
The CCDC11 gene is located on chromosome 18q21.1 and is made of 39303 BP. [2] The CCDC11 protein is made of 514 amino acids and has a mass of 61835 Da. [2] Its aliases include coiled-coil domain containing protein 11, FLJ32743, OTTHUMP00000163503. [2]
CCDC has orthologs all the way back to betaproteobacteria which is a class of Proteobacteria. [2] The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list; however, it shows the diversity of species that CCDC11 is found.
| Species | Organism Common Name | NCBI Accession | Length (AAs) | Sequence Identity | Sequence Similarity |
|---|---|---|---|---|---|
| Homo sapiens | Human | NP_659457 | 514 | 100% | 100% |
| Pan troglodytes | Chimpanzee | XP_523923.3 | 514 | 99% | 99% |
| Callithrix jacchus | Marmoset | XP_002757278.1 | 514 | 92% | 95% |
| Ailuropoda melanoleuca | Panda | XP_002939158.1 | 514 | 83% | 91% |
| Canis familiaris | Dog | XP_547689.3 | 514 | 82% | 91% |
| Bos taurus | Cow | XP_002697813.1 | 514 | 81% | 91% |
| Loxodonata africana | Elephant | XP_003406348.1 | 514 | 80% | 91% |
| Rattus norvegicus | Rat | XP_001053914.2 | 514 | 71% | 87% |
| Mus musculus | Mouse | NP_083224.2 | 514 | 70% | 87% |
| Ornithorhynchus anatinus | Platypus | XP_001509001.2 | 465 | 49% | 72% |
| Monodelphis domestica | Opossum | XP_001372850.2 | 507 | 47% | 70% |
| Xenopus tropicalis | Frog | NP_001120281.1 | 516 | 39% | 65% |
| Anolis carolinensis | Lizard | XP_003227331.1 | 514 | 37% | 62% |
| Nematostella vectensis | Sea anemone | XP_001628275.1 | 440 | 36% | 58% |
| Branchiostoma floridae | Lancelet | XP_002609924.1 | 528 | 35% | 61% |
| Trichoplax adhaerens | Trichoplax | XP_002111027.1 | 514 | 33% | 60% |
| Danio rerio | Zebra fish | NP_001038595.2 | 519 | 32% | 58% |
| Amphimedon queenslandica | Sponge | XP_003389146.1 | 513 | 31% | 60% |
The below image from NCBI shows the gene neighborhood of CCDC11 on chromosome 18. CCDC11 has methyl-CPG binding domain protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11.
Tools on the ExPASy Proteomics site [3] predict the following post-translational modifications:
| Tool | Predicted Modification | Homo sapiens | Mus musculus | Bos taurus |
|---|---|---|---|---|
| YinOYang [4] | O-β-GlcNAc | T239, S510 | T239 | T239, S509, T510 |
| NetPhos [5] | phosphorylation | T8, T17, S43, S53, S56, S57, Y112, T134, S170, S240, S425, S461 | T17, S43, S53, S56, S107, Y112, S114, S170, T284, S287, S492 | T17, S56, T64, S107, T112, T122, T325, S442, S482, S507 |
One tool on the ExPASy, iPSORT, showed no signal peptide;however, it indicated CCDC11 to be mitochondrial. Another tool on the ExPASy, SOSUI, indicated the protein to be a soluble protein.