CCDC116, also called coiled-coil domain containing 116, is a gene that is patented for experimentation on the possibility of being a cancer marker for prostate cancer.
CCDC116 has no aliases. [1] This gene is 2252 base pairs long. [2] CCDC116 has 5 exons and is located on chromosome 22q11.21 on the plus strand. [3]
CCDC116 has two isoforms. [3] The isoforms differ in the 3’ UTR and coding sequence. [3]
CCDC116 is 612 amino acids long. [1] CCDC116 is 67.9 kdal. [1] This protein has an isoelectric point of 9.24. [1] This protein is a part of the domain of unknown function 4702. [1]
It is predicted that CCDC116 is located in the nucleus. [4] It is predicted that the membrane typology of this protein is a type 3a rolled up beta sheet. [4] This protein has mostly alpha helices with a few coils. [4]
CCDC116 is primarily found in the testis, although this gene is found in very small amounts in the brain and connective tissue. [1] There are two SNPs that are upstream variants, one that is a downstream variant, one that is an intron variant. [1]
CCDC116 has four promoter regions and eight primary transcripts. [5] Two promoter regions located on the + strand, and two located on the - strand. [5]
CCDC116 has two predicted function partners. NGFRAP is a nerve growth factor receptor associated protein. [1] This gene is believed to play a role in the pathogenesis of neurogenetic diseases, although that claim has not been proven. [1]
There has yet to be any disease association with CCDC116, but currently there is a patent for this gene with the potential for it to be related to cancer. [6] A study was done in 2012 on observing how this gene is expressed in human pancreatic islets and in endocrine pancreatic tumors. [7]