CCL4L1

CCL4L1
Identifiers
Aliases	CCL4L1 , AT744.2, CCL4L, LAG-1, LAG1, SCYA4L, SCYA4L1, MIP-1-beta, SCYA4L2, C-C motif chemokine ligand 4 like 1
External IDs	OMIM: 603782; GeneCards: CCL4L1; OMA:CCL4L1 - orthologs
Gene ontology Molecular function chemokine activity cytokine activity protein binding CCR chemokine receptor binding Cellular component extracellular region extracellular space Biological process lymphocyte chemotaxis chemokine-mediated signaling pathway cellular response to tumor necrosis factor G protein-coupled receptor signaling pathway positive regulation of GTPase activity chemotaxis inflammatory response cellular response to interleukin-1 monocyte chemotaxis neutrophil chemotaxis immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma regulation of signaling receptor activity eosinophil chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388372 n/a Ensembl n/a n/a UniProt Q8NHW4 n/a RefSeq (mRNA) NM_207007 n/a RefSeq (protein) NP_996890 n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene. ^{[2] [3] [4] [5]}

Function

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene. ^[5]

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, Ledbetter DH, Coillie EV, Opdenakker G, Gunge N, Sakaki Y, Iio M, Miura R (Feb 1997). "A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2". Genomics. 34 (2): 236–40. doi:10.1006/geno.1996.0274. PMID   8661057.
3. Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (Jul 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC   330932 . PMID   1972563.
4. Modi WS (Mar 2004). "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12". Genomics. 83 (4): 735–8. doi:10.1016/j.ygeno.2003.09.019. PMID   15028295.
5. "Entrez Gene: CCL4L1 chemokine (C-C motif) ligand 4-like 1" . Retrieved 8 February 2013.

External links

• Human CCL4L2 genome location and CCL4L2 gene details page in the UCSC Genome Browser .

Further reading

• Menten P, Wuyts A, Van Damme J (2003). "Macrophage inflammatory protein-1". Cytokine Growth Factor Rev. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID   12401480.
• Napolitano M, Modi WS, Cevario SJ, et al. (1991). "The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization". J. Biol. Chem. 266 (26): 17531–6. doi: 10.1016/S0021-9258(19)47404-8 . PMID   1894635.
• Baixeras E, Roman-Roman S, Jitsukawa S, et al. (1991). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Mol. Immunol. 27 (11): 1091–102. doi:10.1016/0161-5890(90)90097-J. PMID   2247088.
• Lipes MA, Napolitano M, Jeang KT, et al. (1989). "Identification, cloning, and characterization of an immune activation gene". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9704–8. Bibcode:1988PNAS...85.9704L. doi: 10.1073/pnas.85.24.9704 . PMC   282843 . PMID   2462251.
• Brown KD, Zurawski SM, Mosmann TR, Zurawski G (1989). "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes". J. Immunol. 142 (2): 679–87. doi: 10.4049/jimmunol.142.2.679 . PMID   2521353.
• Zipfel PF, Balke J, Irving SG, et al. (1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors". J. Immunol. 142 (5): 1582–90. doi: 10.4049/jimmunol.142.5.1582 . PMID   2521882.
• Chang HC, Reinherz EL (1989). "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes". Eur. J. Immunol. 19 (6): 1045–51. doi:10.1002/eji.1830190614. PMID   2568930. S2CID   35270650.
• Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). "A novel polypeptide secreted by activated human T lymphocytes". J. Immunol. 143 (9): 2907–16. doi: 10.4049/jimmunol.143.9.2907 . PMID   2809212.
• Lodi PJ, Garrett DS, Kuszewski J, et al. (1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science. 263 (5154): 1762–7. Bibcode:1994Sci...263.1762L. doi:10.1126/science.8134838. PMID   8134838.
• Cocchi F, DeVico AL, Garzino-Demo A, et al. (1996). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. Bibcode:1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID   8525373. S2CID   84062618.
• Bernardini G, Hedrick J, Sozzani S, et al. (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor". Eur. J. Immunol. 28 (2): 582–8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID   9521068. S2CID   29458782.
• Garlisi CG, Xiao H, Tian F, et al. (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID   10540332. S2CID   5044232.
• Modi WS, Bergeron J, Sanford M (2001). "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1". Immunogenetics. 53 (7): 543–9. doi:10.1007/s002510100366. PMID   11685466. S2CID   26940744.
• Guan E, Wang J, Roderiquez G, Norcross MA (2002). "Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity". J. Biol. Chem. 277 (35): 32348–52. doi: 10.1074/jbc.M203077200 . PMID   12070155.
• Townson JR, Barcellos LF, Nibbs RJ (2002). "Gene copy number regulates the production of the human chemokine CCL3-L1". Eur. J. Immunol. 32 (10): 3016–26. doi: 10.1002/1521-4141(2002010)32:10<3016::AID-IMMU3016>3.0.CO;2-D . PMID   12355456.
• Lu J, Honczarenko M, Sloan SR (2004). "Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes". Immunogenetics. 55 (10): 706–11. doi:10.1007/s00251-003-0636-z. PMID   14673550. S2CID   22941034.