CGK733 fraud

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CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence (aging). [1] However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims. [2] [3]

CGK733 was claimed to be an inhibitor of ATM/ATR kinases, [4] [5] which are involved in DNA damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells.

The original report garnered scientific attention, [6] but was retracted in 2008. [7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented. [7]

The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the Korea Advanced Institute of Science & Technology. [2]

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References

  1. ↑ Won J, Kim M, Kim N, Ahn JH, Lee WG, Kim SS, Chang KY, Yi YW, Kim TK (July 2006). "Small molecule-based reversible reprogramming of cellular lifespan". Nat. Chem. Biol. 2 (7): 369–74. doi:10.1038/nchembio800. PMID   16767085. S2CID   85372472. (Retracted, see PMID   18560433)
  2. 1 2 Dennis Normile; Jennifer Couzin (March 5, 2008). "South Korean researcher suspended over charges of scientific misconduct". Science Now. Archived from the original on 2008-03-09. Retrieved 2008-03-17.
  3. ↑ Kenneth J. Moore (2008). "Data Duping". Chemical & Engineering News. Retrieved 2008-04-01.
  4. ↑ Bhattacharya S, Ray RM, Johnson LR (December 2008). "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells". Cell. Signal. 21 (4): 509–22. doi:10.1016/j.cellsig.2008.12.003. PMID   19136059.
  5. ↑ Crescenzi E, Palumbo G, de Boer J, Brady HJ (March 2008). "Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy". Clin. Cancer Res. 14 (6): 1877–87. doi: 10.1158/1078-0432.CCR-07-4298 . PMID   18347191.
  6. ↑ Sarah Everts (2006). "Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells". Chemical & Engineering News. Retrieved 2007-03-09.
  7. 1 2 Won J, Kim M, Kim N, et al. (July 2008). "Retraction: small molecule-based reversible reprogramming of cellular lifespan". Nat. Chem. Biol. 4 (7): 431. doi: 10.1038/nchembio0708-431 . PMID   18560433.
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