Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure, route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia.
Lead poisoning, also known as plumbism and saturnism, is a type of metal poisoning caused by lead in the body. Symptoms may include abdominal pain, constipation, headaches, irritability, memory problems, infertility, and tingling in the hands and feet. It causes almost 10% of intellectual disability of otherwise unknown cause and can result in behavioral problems. Some of the effects are permanent. In severe cases, anemia, seizures, coma, or death may occur.
Syrup of ipecac, or simply ipecac, is a drug that was once widely used as an expectorant and a rapid-acting emetic. It is obtained from the dried rhizome and roots of the ipecacuanha plant, from which it derives its name. It is no longer regularly used in medicine.
Carbon monoxide poisoning typically occurs from breathing in carbon monoxide (CO) at excessive levels. Symptoms are often described as "flu-like" and commonly include headache, dizziness, weakness, vomiting, chest pain, and confusion. Large exposures can result in loss of consciousness, arrhythmias, seizures, or death. The classically described "cherry red skin" rarely occurs. Long-term complications may include chronic fatigue, trouble with memory, and movement problems.
Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. Chelation therapy has a long history of use in clinical toxicology and remains in use for some very specific medical treatments, although it is administered under very careful medical supervision due to various inherent risks, including the mobilization of mercury and other metals through the brain and other parts of the body by the use of weak chelating agents that unbind with metals before elimination, exacerbating existing damage. To avoid mobilization, some practitioners of chelation use strong chelators, such as selenium, taken at low doses over a long period of time.
The University of Nebraska Medical Center (UNMC) is a public academic health science center in Omaha, Nebraska. Founded in 1869 and chartered as a private medical college in 1881, UNMC became part of the University of Nebraska System in 1902. Rapidly expanding in the early 20th century, the university founded a hospital, dental college, pharmacy college, college of nursing, and college of medicine. It later added colleges of public health and allied health professions. One of Omaha's top employers, UNMC has an annual budget of $841.6 million for 2020 to 2021, and an economic impact of $4.8 billion.
James Linder is an American author, academic and businessperson, as well as an authority on university research commercialization. He is chief executive officer (CEO) of Nebraska Medicine, and most recently was president of the University Technology Development Corporation and chief strategist for the University of Nebraska system. He is also a professor of pathology and microbiology at the University of Nebraska Medical Center.
Rodney Smith Markin, is an American pathologist and authority in the field of laboratory automation. In 1993, he designed and created one of the world's first automated clinical laboratory specimen, device and analyzer management systems. In the mid-1990s, he chaired a standards group called the Clinical Testing Automation Standards Steering Committee (CTASSC) of the American Association for Clinical Chemistry, which later evolved into an area committee of the Clinical and Laboratory Standards Institute.
Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include intoxication, vomiting and abdominal pain. Later symptoms may include a decreased level of consciousness, headache, and seizures. Long term outcomes may include kidney failure and brain damage. Toxicity and death may occur after drinking even in a small amount as ethylene glycol is more toxic than other diols.
Benzodiazepine overdose describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial.
Nebraska Medicine, is a private not-for-profit American healthcare company based in Omaha, Nebraska. The company was created as Nebraska Health System (NHS) in 1997, when Bishop Clarkson Hospital merged with the adjacent University Hospital in midtown Omaha. Renamed The Nebraska Medical Center in 2003, in 2014 the company merged with UNMC Physicians and Bellevue Medical Center to become Nebraska Medicine. The company has full ownership of two hospitals and 39 specialty and primary care clinics in and around Omaha, with partial ownership in two rural hospitals and a specialty hospital. Nebraska Medicine's main campus, Nebraska Medicine – Nebraska Medical Center, has 718 beds, while its Bellevue Medical Center campus has 91 beds.
Chromium toxicity refers to any poisonous toxic effect in an organism or cell that results from exposure to specific forms of chromium—especially hexavalent chromium. Hexavalent chromium and its compounds are toxic when inhaled or ingested. Trivalent chromium is a trace mineral that is essential to human nutrition. There is a hypothetical risk of genotoxicity in humans if large amounts of trivalent chromium were somehow able to enter living cells, but normal metabolism and cell function prevent this.
Jeffrey A. Brent is a medical toxicologist who is a distinguished clinical professor of medicine and emergency medicine at the University of Colorado, School of Medicine. In addition, he is a professor at the Department of Environmental and Occupational Health at the Colorado School of Public Health. He is also the past president of the American Academy of Clinical Toxicology, was editor in chief of the journal Toxicological Reviews, and was a member of the board of directors of the American College of Medical Toxicology. Previously, most of Brent's research focused on the use of fomepizole as a treatment for both methanol and ethylene glycol poisoning, and he led a trial of this drug which resulted in the FDA approving it in December 1997. Currently, Brent serves as Director of the Toxicology Investigators Consortium, an NIH and FDA supported multi center research and surveillance group. Brent is also a senior editor of "Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient," originally published in 2005, and now in its second edition, which was published in 2017.
Jeffrey Philip Gold is an American surgeon, medical educator, and academic administrator who has been the president of the University of Nebraska system since July 1, 2024. Prior to that, he served as the chancellor of the University of Nebraska Medical Center since February 1, 2014, as well as the executive vice president and provost of the University of Nebraska system since 2021. He also previously served as the interim chancellor and then chancellor of the University of Nebraska Omaha from May 2017 to June 2021.
Steven A. Seifert (1950–2022) was an American medical toxicologist. He was a professor of emergency medicine at the University of New Mexico, as well as the medical director of the New Mexico Poison and Drug Information Center. Since 2017, he was the editor-in-chief of Clinical Toxicology. He was also a jazz tenor saxophonist.
Shelby Kutty is an Indian-born American cardiologist, a professor of pediatrics and internal medicine at the Johns Hopkins University School of Medicine. He holds the Helen B. Taussig endowed professorship at Johns Hopkins and is Director of the Helen B. Taussig Heart Center at the Johns Hopkins Hospital. Prior to this, he held the title of assistant dean for research and development and vice chair of pediatrics at the University of Nebraska Medical Center College of Medicine.
Jasmine R. Marcelin is a Caribbean-American infectious disease physician and an Assistant Professor in the Department of Internal Medicine at the University of Nebraska Medical Center (UNMC). Marcelin is also the Associate Medical Director of the Antimicrobial Stewardship Program and as well as the Co-Director of Digital Innovation and Social Media Strategy at UNMC.
Barry H. Rumack is an American medical toxicologist and pediatrician. His primary clinical and research interest has been in clinical toxicology with a special interest in acetaminophen poisoning. Since 2014 he is emeritus professor of emergency medicine and pediatrics at the University of Colorado School of Medicine.
John J. Lowe is an American infectious disease scientist, assistant vice chancellor for health security at University of Nebraska Medical Center, and associate professor in the Department of Environmental, Agricultural and Occupational Health at University of Nebraska Medical Center College of Public Health. In 2014, he led Nebraska Medicine hospital’s effort to treat and care for Ebola virus disease patients and led the University of Nebraska Medical Center’s coronavirus disease 2019 response efforts.
Howard E. Gendelman is an American physician-scientist whose research intersects the disciplines of neuroimmunology, pharmacology, and infectious diseases. Gendelman was born in Philadelphia, Pennsylvania. His research is focused on harnessing immune responses for therapeutic gain in HIV/AIDS and Neurodegenerative disease. He is the Margaret R. Larson Professor of infectious diseases and internal medicine at the University of Nebraska Medical Center (UNMC) in Omaha.
