Chakragati mouse

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Chakragati mouse (ckr) is an insertional transgenic mouse mutant ( Mus musculus ) displaying hyperactive behaviour and circling. It is also deficient in prepulse inhibition, latent inhibition [1] and has brain abnormalities such as lateral ventricular enlargement [2] that are typical to endophenotypic models of schizophrenia, which make it useful in screening for antipsychotic drug candidates. [3] The mouse is currently licensed by Chakra Biotech.

References

  1. Verma V, Tan CH, Ong WY, et al. (March 2008). "The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition". Neurosci. Res. 60 (3): 281–8. doi:10.1016/j.neures.2007.11.007. PMID   18164085. S2CID   207150983.
  2. Torres G, Meeder BA, Hallas BH, et al. (2005). "Ventricular size mapping in a transgenic model of schizophrenia". Developmental Brain Research. 154 (1): 35–44. doi:10.1016/j.devbrainres.2004.08.011. PMID   15617753.
  3. Dawe GS, Ratty AK (2007). "The chakragati mouse: A mouse model for rapid in vivo screening of antipsychotic drug candidates". Biotechnology Journal. 2 (11): 1344–52. doi:10.1002/biot.200700145. PMID   17886239. S2CID   24748043.