Charles Antzelevitch | |
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| Alma mater | Queens College (BA) State University of New York Upstate Medical University (PhD) |
| Scientific career | |
| Fields | Cardiology, Electrophysiology, Pharmacology, Genetics |
| Institutions | Lankenau Institute for Medical Research |
Charles Antzelevitch is an American cardiovascular research scientist in the fields of cardiac electrophysiology and cardiac arrhythmia syndromes. [1]
Antzelevitch graduated from Queens College, City University of New York with a BA in biology. He earned a PhD in pharmacology from State University of New York Upstate Medical University in 1978. [1] From 1977 to 1980, he held a postdoctoral fellowship in the department of experimental cardiology at the Masonic Medical Research Laboratory (MMRL) in Utica, New York. [2]
After his fellowship, he joined the staff of the MMRL as a research scientist. In 1984, he was named executive director and director of research at the MMRL and was appointed the Gordon K. Moe Scholar, an endowed chair in experimental cardiology, in 1987. [2]
Antzelevitch was a member of the faculty at State University of New York Upstate Medical University in Syracuse, New York, from 1980 until 2015. In 1980, he received an appointment as assistant professor in the department of pharmacology there. In 1983, he was promoted to associate professor and then in 1986, to research professor. He became professor of pharmacology in 1995. [2] [3] In 2015, Antzelevitch moved to the Lankenau Institute for Medical Research (LIMR), where he was appointed professor and executive director of cardiovascular research and director of research at the Lankenau Heart Institute. In 2020, he was designated as distinguished professor emeritus at LIMR. [4] [1]
Antzelevitch was president of the International Cardiac Electrophysiology Society from 1996 to 1998 [5] and has served as secretary/treasurer since 1998. [6] He serves as Associate Editor of Heart Rhythm journal as well as on the editorial board of several other peer-reviewed medical publications, including Journal of Electrocardiology [7] and Journal of the American College of Cardiology . [8] He received the Distinguished Scientist Award from the North American Society of Pacing and Electrophysiology (NASPE), currently the Heart Rhythm Society (HRS 2002), [9] Excellence in Cardiovascular Science Award from the NE Affiliate of the American Heart Association (AHA 2003), [10] Carl J. Wiggers Award from the American Physiological Society (2007), [11] [12] Distinguished Scientist Award from the American College of Cardiology (ACC 2011), [9] [13] Distinguished Service Award from the Cardiac Electrophysiology Society (2015), [14] the Douglas P. Zipes Lecture Award from the Heart Rhythm Society (2016) [10] and the Lifetime Achievement Award from the American College of Cardiology (ACC 2020). [15]
Cardiology is a branch of medicine that deals with the disorders of the heart as well as some parts of the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology. Physicians who specialize in this field of medicine are called cardiologists, a specialty of internal medicine. Pediatric cardiologists are pediatricians who specialize in cardiology. Physicians who specialize in cardiac surgery are called cardiothoracic surgeons or cardiac surgeons, a specialty of general surgery.
Brugada syndrome (BrS) is a genetic disorder in which the electrical activity within the heart is abnormal. It increases the risk of abnormal heart rhythms and sudden cardiac death. Those affected may have episodes of passing out. The abnormal heart rhythms seen in those with Brugada syndrome often occur at rest. They may be triggered by a fever.
Long QT syndrome (LQTS) is a condition in which repolarization of the heart after a heartbeat is affected. It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. These episodes can be triggered by exercise or stress. Some rare forms of LQTS are associated with other symptoms and signs including deafness and periods of muscle weakness.
Short QT syndrome (SQT) is a very rare genetic disease of the electrical system of the heart, and is associated with an increased risk of abnormal heart rhythms and sudden cardiac death. The syndrome gets its name from a characteristic feature seen on an electrocardiogram (ECG) – a shortening of the QT interval. It is caused by mutations in genes encoding ion channels that shorten the cardiac action potential, and appears to be inherited in an autosomal dominant pattern. The condition is diagnosed using a 12-lead ECG. Short QT syndrome can be treated using an implantable cardioverter-defibrillator or medications including quinidine. Short QT syndrome was first described in 2000, and the first genetic mutation associated with the condition was identified in 2004.
Torsades de pointes, torsade de pointes or torsades des pointes (TdP) is a specific type of abnormal heart rhythm that can lead to sudden cardiac death. It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG). It was described by French physician François Dessertenne in 1966. Prolongation of the QT interval can increase a person's risk of developing this abnormal heart rhythm, occurring in between 1% and 10% of patients who receive QT-prolonging antiarrhythmic drugs.
Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. It is only recommended in those with significant abnormal heart rhythms due to potentially serious side effects. Evidence does not support a decreased risk of death with long term use. It is taken by mouth or injection into a vein.
Jervell and Lange-Nielsen syndrome (JLNS) is a rare type of long QT syndrome associated with severe, bilateral sensorineural hearing loss. Those with JLNS are at risk of abnormal heart rhythms called arrhythmias, which can lead to fainting, seizures, or sudden death. JLNS, like other forms of long QT syndrome, causes the cardiac muscle to take longer than usual to recharge between beats. It is caused by genetic variants responsible for producing ion channels that carry transport potassium out of cells. The condition is usually diagnosed using an electrocardiogram, but genetic testing can also be used. Treatment includes lifestyle measures, beta blockers, and implantation of a defibrillator in some cases. It was first described by Anton Jervell and Fred Lange-Nielsen in 1957.
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited genetic disorder that predisposes those affected to potentially life-threatening abnormal heart rhythms or arrhythmias. The arrhythmias seen in CPVT typically occur during exercise or at times of emotional stress, and classically take the form of bidirectional ventricular tachycardia or ventricular fibrillation. Those affected may be asymptomatic, but they may also experience blackouts or even sudden cardiac death.
Mark E. Josephson (1943-2017) was an American cardiologist and writer, who was in the 1970s one of the American pioneers of the medical cardiology subspecialty of cardiac electrophysiology. His book titled Clinical Cardiac Electrophysiology: Techniques and Interpretations is widely acknowledged as the definitive treatment of the discipline. He served as Herman Dana Professor of Medicine at Harvard Medical School, director of the Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service and the chief of cardiology at Harvard University's Beth Israel Deaconess Medical Center in Boston.
Michel Haïssaguerre is a French cardiologist and electrophysiologist. His investigations have been the basis for development of new markers and therapies for atrial and ventricular fibrillation.
D. George Wyse FRCPC is the Chair of the International Experts Advisory Committee of the Libin Cardiovascular Institute of Alberta (LCIA). Wyse is a recognized and decorated international expert in the area of cardiac arrhythmias. His research led to fundamental changes in the way cardiac arrhythmias are treated, in specific, the reduction in use of certain antiarrhythmic agents.
Henrick Joan Joost Wellens, M.D., (1935–2020) was a Dutch cardiologist who is considered one of the founding fathers of the cardiology subspecialty known as clinical cardiac electrophysiology. Clinical cardiac electrophysiology enables patients with cardiac arrhythmias to be subjected to catheter electrode mapping and stimulation studies.
Arrhythmias, also known as cardiac arrhythmias, heart arrhythmias, or dysrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. A heart rate that is too fast – above 100 beats per minute in adults – is called tachycardia, and a heart rate that is too slow – below 60 beats per minute – is called bradycardia. Some types of arrhythmias have no symptoms. Symptoms, when present, may include palpitations or feeling a pause between heartbeats. In more serious cases, there may be lightheadedness, passing out, shortness of breath or chest pain. While most cases of arrhythmia are not serious, some predispose a person to complications such as stroke or heart failure. Others may result in sudden death.
Benign early repolarization also known as early repolarization is found on ECG in about 1% of those with chest pain. It is diagnosed based on an elevated J-point / ST elevation where the ST segment is concave up. It is believed to be a normal variant.
Frank I. Marcus is an American cardiologist and Emeritus Professor of Medicine at the University of Arizona Health Sciences Center, the author of more than 290 publications in peer-reviewed medical journals and of 90 book chapters. He is considered a world expert on arrhythmogenic right ventricular cardiomyopathy (ARVC) and has been or is a member of the Editorial/Scientific Board of 14 Cardiovascular Journals as well as a reviewer for 26 other medical publications.
Peter R. Kowey is an American cardiologist and medical researcher. He is Professor of Medicine and Clinical Pharmacology at Jefferson Medical College of Thomas Jefferson University and holds the William Wikoff Smith Chair in Cardiovascular Research at Lankenau Institute for Medical Research.
Kewal Kishan Talwar is an Indian cardiologist, medical academic and writer, and a former chairman of the Medical Council of India. He is a former director of the Post Graduate Institute of Medical Education and Research (PGIMER) and is reported to have performed the first implantation of Implantable cardioverter-defibrillator (ICD) therapy in South Asia. He is also credited with the introduction of Cardiac Resynchronization Therapy in India. He is a recipient of several honours including B. C. Roy Award, the highest Indian award in the medical category. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 2006, for his contributions to medicine. Presently Dr. Talwar is working in PSRI Hospital Sheikh Sarai, New Delhi as the chairman of Cardiac Sciences
Gan-Xin Yan is an American cardiologist, electrophysiologist and cardiovascular research scientist whose studies of arrhythmias have contributed to an understanding of J wave syndromes, long QT syndrome, and other abnormalities that can lead to sudden cardiac death. Yan is a professor at Lankenau Institute for Medical Research (LIMR) and a practicing cardiologist and electrophysiologist at Lankenau Medical Center, both located in Wynnewood, Pennsylvania. He also holds positions as professor of medicine at Sidney Kimmel Medical College of Thomas Jefferson University in Philadelphia and Xi'an Jiaotong University in Xi'an, Shaanxi, China.
Sports cardiology is an emerging subspecialty field of Cardiology. It may also be considered a subspecialty field of Sports medicine, or alternatively a hybrid subspecialty that spans cardiology and sports medicine. Emergency medicine is another medical specialty that has some overlap with Sports Cardiology. Sports cardiology is now considered to be a distinct subspecialty in Europe and the USA, with a core curriculum developed in both regions. In Europe it has traditionally been grouped under Preventive Cardiology, but the subspecialty of Sports Cardiology is now considered a distinct field. In the USA, it has developed from being a special interest area to a distinct subspecialty as well.
Günter Breithardt is a German physician, cardiologist and emeritus university professor. He is known for his research in the field of rhythmology, especially the diagnosis and pharmacological and non-pharmacological therapy of cardiac arrhythmias and acute cardiac death, in particular the identification of arrhythmia-triggering gene mutations. For 21 years he headed the Medical Clinic and Polyclinic C at Münster University Hospital. A number of his academic students hold university management and chief physician positions.
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