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Hormone-sensitive lipase (EC 3.1.1.79, HSL), also previously known as cholesteryl ester hydrolase (CEH), sometimes referred to as triacylglycerol lipase, is an enzyme that, in humans, is encoded by the LIPE gene, and catalyzes the following reaction:
David S. Cafiso is an American biochemist and a professor of chemistry at the University of Virginia. His research focuses on membrane proteins and cell signaling, and is primarily supported by grants from the National Institute of Health.
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The cell membrane is a biological membrane that separates and protects the interior of all cells from the outside environment. The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols interspersed between them, maintaining appropriate membrane fluidity at various temperatures. The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane transporters, and peripheral proteins that loosely attach to the outer (peripheral) side of the cell membrane, acting as enzymes to facilitate interaction with the cell's environment. Glycolipids embedded in the outer lipid layer serve a similar purpose. The cell membrane controls the movement of substances in and out of cells and organelles, being selectively permeable to ions and organic molecules. In addition, cell membranes are involved in a variety of cellular processes such as cell adhesion, ion conductivity, and cell signalling and serve as the attachment surface for several extracellular structures, including the cell wall and the carbohydrate layer called the glycocalyx, as well as the intracellular network of protein fibers called the cytoskeleton. In the field of synthetic biology, cell membranes can be artificially reassembled.
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Patrick J. (Pat) Casey is a biochemist and molecular pharmacologist and is a James B. Duke Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. In 2005, he relocated to Singapore to help found the Duke-NUS Medical School Singapore, where he continues to serve as its Senior Vice Dean of Research.
Françoise Gisou van der Goot is a Swiss-Dutch cell biologist. She is a professor and the Vice President for Responsible Transformation at EPFL.
Rose Mamelak Johnstone FRSC was a Canadian biochemist who is known for her discovery of exosomes, the cellular structures that transport proteins, lipids and RNA. She was the first woman to hold the Gilman Cheney Chair in Biochemistry (1985) and the first and only woman chair of the Department of Biochemistry in McGill University's Faculty of Medicine (1980-1990).
Marnie Halpern is the Andrew J. Thomson Professor and Chair of molecular and systems biology at the Geisel School of Medicine at Dartmouth College. She is a Pew Scholar in the Biomedical Sciences. and a Fellow of the American Association for the Advancement of Science.
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References
- 1 2 3 4 5 6 "Lab Members". Dartmouth College. Archived from the original on May 15, 2017. Retrieved May 29, 2017.
- ↑ "Charles K. Barlowe". Dartmouth College. Retrieved May 29, 2017.
- 1 2 "Fellows". American Society For Microbiology. Archived from the original on December 14, 2018. Retrieved May 29, 2017.
- ↑ "Scholars". Pew Charitable Trusts. Retrieved May 29, 2017.
- ↑ "Biographical Sketch - Charles Barlowe" (PDF). geiselmed.dartmouth.edu. via Dartmouth School of Medicine. Retrieved 10 December 2018.
- ↑ "Charles Barlowe". American Association for the Advancement of Science. Retrieved May 29, 2017.[ permanent dead link ]