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In statistics, cluster sampling is a sampling plan used when mutually homogeneous yet internally heterogeneous groupings are evident in a statistical population. It is often used in marketing research.
A randomized controlled trial is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical techniques, medical devices, diagnostic procedures or other medical treatments.
Cochrane is a British international charitable organisation formed to synthesize medical research findings to facilitate evidence-based choices about health interventions involving health professionals, patients and policy makers. It includes 53 review groups that are based at research institutions worldwide. Cochrane has approximately 30,000 volunteer experts from around the world.
In a blind or blinded experiment, information which may influence the participants of the experiment is withheld until after the experiment is complete. Good blinding can reduce or eliminate experimental biases that arise from a participants' expectations, observer's effect on the participants, observer bias, confirmation bias, and other sources. A blind can be imposed on any participant of an experiment, including subjects, researchers, technicians, data analysts, and evaluators. In some cases, while blinding would be useful, it is impossible or unethical. For example, it is not possible to blind a patient to their treatment in a physical therapy intervention. A good clinical protocol ensures that blinding is as effective as possible within ethical and practical constraints.
Sir Richard Peto is an English statistician and epidemiologist who is Professor of Medical Statistics and Epidemiology at the University of Oxford, England.
A pilot experiment, pilot study, pilot test or pilot project is a small-scale preliminary study conducted to evaluate feasibility, duration, cost, adverse events, and improve upon the study design prior to performance of a full-scale research project.
A hierarchy of evidence, comprising levels of evidence (LOEs), that is, evidence levels (ELs), is a heuristic used to rank the relative strength of results obtained from experimental research, especially medical research. There is broad agreement on the relative strength of large-scale, epidemiological studies. More than 80 different hierarchies have been proposed for assessing medical evidence. The design of the study and the endpoints measured affect the strength of the evidence. In clinical research, the best evidence for treatment efficacy is mainly from meta-analyses of randomized controlled trials (RCTs). Systematic reviews of completed, high-quality randomized controlled trials – such as those published by the Cochrane Collaboration – rank the same as systematic review of completed high-quality observational studies in regard to the study of side effects. Evidence hierarchies are often applied in evidence-based practices and are integral to evidence-based medicine (EBM).
In medicine an intention-to-treat (ITT) analysis of the results of a randomized controlled trial is based on the initial treatment assignment and not on the treatment eventually received. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as non-random attrition of participants from the study or crossover. ITT is also simpler than other forms of study design and analysis, because it does not require observation of compliance status for units assigned to different treatments or incorporation of compliance into the analysis. Although ITT analysis is widely employed in published clinical trials, it can be incorrectly described and there are some issues with its application. Furthermore, there is no consensus on how to carry out an ITT analysis in the presence of missing outcome data.
Zelen's design is an experimental design for randomized clinical trials proposed by Harvard School of Public Health statistician Marvin Zelen (1927-2014). In this design, patients are randomized to either the treatment or control group before giving informed consent. Because the group to which a given patient is assigned is known, consent can be sought conditionally.
A nurse-led clinic is any outpatient clinic that is run or managed by registered nurses, usually nurse practitioners or Clinical Nurse Specialists in the UK. Nurse-led clinics have assumed distinct roles over the years, and examples exist within hospital outpatient departments, public health clinics and independent practice environments.
In science, randomized experiments are the experiments that allow the greatest reliability and validity of statistical estimates of treatment effects. Randomization-based inference is especially important in experimental design and in survey sampling.
Consolidated Standards of Reporting Trials (CONSORT) encompasses various initiatives developed by the CONSORT Group to alleviate the problems arising from inadequate reporting of randomized controlled trials. It is part of the larger EQUATOR Network initiative to enhance the transparency and accuracy of reporting in research.
Targeted intra-operative radiotherapy, also known as targeted IORT, is a technique of giving radiotherapy to the tissues surrounding a cancer after its surgical removal, a form of intraoperative radiation therapy. The technique was designed in 1998 at the University College London.
Three Degrees of Influence is a theory in the realm of social networks, proposed by Nicholas A. Christakis and James H. Fowler in 2007. It has since been explored by scientists in numerous disciplines using diverse statistical, psychological, sociological, and biological approaches.
PRISMA is an evidence-based minimum set of items aimed at helping scientific authors to report a wide array of systematic reviews and meta-analyses, primarily used to assess the benefits and harms of a health care intervention. PRISMA focuses on ways in which authors can ensure a transparent and complete reporting of this type of research. The PRISMA standard superseded the earlier QUOROM standard. It offers the replicability of a systematic literature review. Researchers have to figure out research objectives that answer the research question, states the keywords, a set of exclusion and inclusion criteria. In the review stage, relevant articles were searched, irrelevant ones are removed. Articles are analyzed according to some pre-defined categories.
Associations have been shown between vitamin D levels and several respiratory tract infections suggesting that vitamin D deficiency may predispose to infection. Outbreaks of respiratory infections occur predominantly during months associated with lower exposure to the sun. The Institute of Medicine concluded in a 2011 report that the existing data were "not consistently supportive of a causal role" for vitamin D in reducing the risk of infection. Other studies suggest that vitamin D supplementation can provide a protective role in reducing the incidence or severity of respiratory infections.
In medicine, a stepped-wedge trial is a type of randomised controlled trial (RCT). An RCT is a scientific experiment that is designed to reduce bias when testing a new medical treatment, a social intervention, or another testable hypothesis.
Melissa Anne Wake MBChB MD FRACP FAHMS is a New Zealand paediatrician and Scientific Director of the Generation Victoria initiative, aiming to create very large, parallel whole-of-state birth and parent cohorts in Victoria, Australia, for Open Science discovery and interventional research. She is Group Leader of the Murdoch Children's Research Institute’s Prevention Innovation Research Group and holds Professorial positions with the University of Melbourne and the University of Auckland.
The Randomised Evaluation of COVID-19 Therapy is a large-enrollment clinical trial of possible treatments for people in the United Kingdom admitted to hospital with severe COVID-19 infection. The trial was later expanded to Indonesia, Nepal and Vietnam. The trial has tested ten interventions on adults: eight repurposed drugs, one newly developed drug and convalescent plasma.
A non-pharmaceutical intervention or non-pharmacological intervention (NPI) is any type of health intervention which is not primarily based on medication. Some examples include exercise, sleep improvement, or dietary habits.
References
- 1 2 Bland JM (2004). "Cluster randomised trials in the medical literature: two bibliometric surveys". BMC Med Res Methodol. 4: 21. doi: 10.1186/1471-2288-4-21 . PMC 515302 . PMID 15310402.
- 1 2 Campbell MK, Elbourne DR, Altman DG, CONSORT group (2004). "CONSORT statement: extension to cluster randomised trials". BMJ. 328 (7441): 702–8. doi:10.1136/bmj.328.7441.702. PMC 381234 . PMID 15031246.
- ↑ Murray DM, Varnell SP, Blitstein JL (2004). "Design and analysis of group-randomized trials: a review of recent methodological developments". Am J Public Health. 94 (3): 423–32. doi:10.2105/AJPH.94.3.423. PMC 1448268 . PMID 14998806.
- ↑ Patton GC, Bond L, Carlin JB, Thomas L, Butler H, Glover S, Catalano R, Bowes G (2006). "Promoting social inclusion in schools: a group-randomized trial of effects on student health risk behavior and well-being". Am J Public Health. 96 (9): 1582–7. doi:10.2105/AJPH.2004.047399. PMC 1551970 . PMID 16873760.
- ↑ Boruch R, May H, Turner H, Lavenberg J, Petrosino A, De Moya D, Grimshaw J, Foley E (2004). "Estimating the effects of interventions that are deployed in many places: place-randomized trials". American Behavioral Scientist . 47 (5): 608–633. doi:10.1177/0002764203259291. S2CID 910678.[ permanent dead link ]
- 1 2 Murray, David M.; Taljaard, Monica; Turner, Elizabeth L.; George, Stephanie M. (2020). "Essential Ingredients and Innovations in the Design and Analysis of Group-Randomized Trials". Annual Review of Public Health. 41: 1–19. doi: 10.1146/annurev-publhealth-040119-094027 . PMID 31869281.
- ↑ Edwards SJ, Braunholtz DA, Lilford RJ, Stevens AJ (1999). "Ethical issues in the design and conduct of cluster randomised controlled trials". BMJ. 318 (7195): 1407–9. doi:10.1136/bmj.318.7195.1407. PMC 1115783 . PMID 10334756.
- ↑ Sampling People, Networks and Records coursers course (worth finding a better reference)