Crystal cells

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Crystal cells are one class of hemocytes (blood cells) in Drosophila melanogaster . [1] They play a primary role in wound healing and Reactive Oxygen Species Production. They heal wounds primarily by creating a melanized mass analogous to a human blood clot or scab. [2] Reactive oxygen species production is important for fighting off infections. Crystal cells are larger than plasmatocytes and smaller than Lamellocytes and can be identified by their prominent prophenoloxidasae (PPO) crystals, which are the main protein structures which allow them to melanize. Crystal cells have also been shown to carry oxygen. [3]

Crystal cells in Drosophila are analogous to oenocytoids in other insects. [4]

References

  1. ↑ Banerjee, Utpal; Girard, Juliet; Goins, Lauren; Spratford, Carrie (February 1, 2019). "Drosophila as a Genetic Model for Hematopoiesis". Genetics. 211 (2): 367–417. doi:10.1534/genetics.118.300223. PMC   6366919 . PMID   30733377 . Retrieved 12 April 2025.
  2. ↑ Gawa, Bidla; Malin, Lindgren; Theopold, Ulrich; Dushay, Mitchell (2005-01-01). "Hemolymph Coagulation and Phenoloxidase in Drosophila Larvae" . Developmental & Comparitive Immunology. 29 (8): 669–679. doi:10.1016/j.dci.2004.11.007. PMID   15854679 . Retrieved 12 April 2025.
  3. ↑ Shin, Mingyu; Chang, Eunji; Lee, Daewon; Kim, Nayun; Cho, Bumsik; Cha, Nuri; Koranteng, Ferdinand; Song, Ji-Joon; Shim, Jiwon (2024-06-26). "Drosophila immune cells transport oxygen through PPO2 protein phase transition". Nature. 631 (8020): 350–359. Bibcode:2024Natur.631..350S. doi:10.1038/s41586-024-07583-x. PMC   11236712 . PMID   38926577.
  4. ↑ Hultmark, Dan; Andó, István (August 3, 2022). "Hematopoietic plasticity mapped in Drosophila and other insects". eLife. 11. doi: 10.7554/eLife.78906 . PMC   9348853 . PMID   35920811.
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