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Cloning is the process of producing individual organisms with identical genomes, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction; this reproduction of an organism by itself without a mate is known as parthenogenesis. In the field of biotechnology, cloning is the process of creating cloned organisms of cells and of DNA fragments.
In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. The technique consists of taking an denucleated oocyte and implanting a donor nucleus from a somatic (body) cell. It is used in both therapeutic and reproductive cloning. In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques from foetal nuclei.
The University of Hawaiʻi System is a public college and university system. The system confers associate, bachelor's, master's, and doctoral degrees through three universities, seven community colleges, an employment training center, three university centers, four education centers and various other research facilities distributed across six islands throughout the state of Hawaii in the United States. All schools of the University of Hawaiʻi system are accredited by the Western Association of Schools and Colleges. The UH system's main administrative offices are located on the property of the University of Hawaiʻi at Mānoa in Honolulu CDP.
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells. Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the blastocyst, a process which raises ethical issues, including whether or not embryos at the pre-implantation stage have the same moral considerations as embryos in the post-implantation stage of development.
Sir John Bertrand Gurdon is a British developmental biologist, best known for his pioneering research in nuclear transplantation and cloning.
Sir Ian Wilmut was a British embryologist and the chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly.
Sir Martin John EvansFLSW is an English biologist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981. He is also known, along with Mario Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic stem cells to create specific gene modifications in mice. In 2007, the three shared the Nobel Prize in Physiology or Medicine in recognition of their discovery and contribution to the efforts to develop new treatments for illnesses in humans.
Ryuzo Yanagimachi was a Japanese-born, American-based scientist. He made numerous key contributions to the study of mammalian fertilization, and he was also a pioneer in the cloning field. Accordingly, he assisted in fertilization technologies such as in vitro fertilization and direct sperm injection into the egg, which are widely used today in human infertility clinics throughout the world. In 1997, his laboratory at the University of Hawaiʻi at Mānoa successfully cloned mice using the Honolulu technique.
The Jackson Laboratory is an independent, non-profit biomedical research institution which was founded by Clarence Cook Little in 1929. It employs over 3,000 employees in Bar Harbor, Maine; Sacramento, California; Farmington, Connecticut; Shanghai, China; and Yokohama, Japan. The institution is a National Cancer Institute-designated Cancer Center and has NIH Centers of Excellence in aging and systems genetics. The stated mission of The Jackson Laboratory is "to discover the genetic basis for preventing, treating and curing human diseases, and to enable research and education for the global biomedical community."
Andrzej Krzysztof Tarkowski was a Polish embryologist and a professor at Warsaw University. He is best known for his pioneering researches on embryos and blastomeres, which have created theoretical and practical basis for achievements of biology and medicine of the twentieth century - in vitro fertilization, cloning and stem cell discovery. In 2002 Tarkowski with Anne McLaren won the Japan Prize for their discoveries concerning the early development of mammalian embryos.
Dame Anne Laura Dorinthea McLaren, was a British scientist who was a leading figure in developmental biology. She paved the way for women in science and her work helped lead to human in vitro fertilisation (IVF). She left an enduring legacy marked by her research and ethical contributions to the field. She received many honors for her contributions to science, including election as fellow of the Royal Society.
John Edgar Dick is Canada Research Chair in Stem Cell Biology, Senior Scientist at the Princess Margaret Cancer Centre, University Health Network and Professor in the Department of Molecular Genetics at the University of Toronto in Canada. Dick is credited with first identifying cancer stem cells in certain types of human leukemia. His revolutionary findings highlighted the importance of understanding that not all cancer cells are the same and thus spawned a new direction in cancer research. Dick is also known for his demonstration of a blood stem cell's ability to replenish the blood system of a mouse, his development of a technique to enable an immune-deficient mouse to carry and produce human blood, and his creation of the world's first mouse with human leukemia.
Kevin Eggan is a Professor of Stem Cell and Regenerative Biology at Harvard University, known for his work in stem cell research, and as a spokesperson for stem cell research in the United States. He was a 2006 recipient of a MacArthur Fellowship. In 2005, he was named to the MIT Technology Review TR35 as one of the top 35 innovators in the world under the age of 35.
Ralph Lawrence Brinster is an American geneticist, National Medal of Science laureate, and Richard King Mellon Professor of Reproductive Physiology at the School of Veterinary Medicine, University of Pennsylvania.
Genetically modified mammals are mammals that have been genetically engineered. They are an important category of genetically modified organisms. The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells.
Beatrice Mintz was an American embryologist who contributed to the understanding of genetic modification, cellular differentiation, and cancer, particularly melanoma. Mintz was a pioneer of genetic engineering techniques and was among the first scientists to generate both chimeric and transgenic mammals.
Jacqueline N. Crawley is an American behavioral neuroscientist and an expert on rodent behavioral analysis. Since July 2012, she is the Robert E. Chason Chair in Translational Research in the MIND Institute and professor of psychiatry and behavioral sciences at the University of California, Davis School of Medicine in Sacramento. Previously, from 1983–2012, she was chief of the Laboratory of Behavioral Neuroscience in the intramural program of the National Institute of Mental Health. Her translational research program focuses on testing hypotheses about the genetic causes of autism spectrum disorders and discovering treatments for the diagnostic symptoms of autism, using mouse models. She has published more than 275 peer-reviewed articles in scientific journals and 110 review articles and book chapters. According to Scopus, her works have been cited over 36,000 times, giving her an h-index of 99. She has co-edited 4 books and is the author of What's Wrong With my Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, which was very well received.
A knockout mouse, or knock-out mouse, is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are important animal models for studying the role of genes which have been sequenced but whose functions have not been determined. By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function.
Rudolph Leibel is the Christopher J. Murphy Professor of Diabetes Research, Professor of Pediatrics and Medicine at Columbia University Medical Center, and Director of the Division of Molecular Genetics in the Department of Pediatrics. He is also co-director of the Naomi Berrie Diabetes Center and executive director of the Russell and Angelica Berrie Program in Cellular Therapy, Co-director of the New York Obesity Research Center and the Columbia University Diabetes and Endocrinology Research Center.
References
- ↑ "Honolulu Star-Bulletin Local News". Archived from the original on 2007-03-10. Retrieved 2005-08-21.
- ↑ "Honolulu Star-Bulletin Hawaii News". Archived from the original on 2007-02-09. Retrieved 2005-08-21.
