DISC2

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DISC2
Identifiers
Aliases DISC2 , DISC1-AS1, DISC1OS, NCRNA00015, disrupted in schizophrenia 2 (non-protein coding), disrupted in schizophrenia 2
External IDs OMIM: 606271 GeneCards: DISC2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed search [1] n/a
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In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is a long non-coding RNA molecule. In humans, the DISC2 gene that produces the DISC2 RNA molecule is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia. [2] It is antisense to the DISC1 gene and may regulate the expression of DISC1. [2] [3] DISC2 may also contribute to other psychiatric disorders. [3] [4]

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Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research. Although, recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level, the DISC1 interactome gene set was associated with schizophrenia, showing evidence from genome-wide association studies of the role of DISC1 and interacting partners in schizophrenia susceptibility.

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References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. 1 2 Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics. 9 (9): 1415–1423. doi: 10.1093/hmg/9.9.1415 . PMID   10814723.
  3. 1 2 Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID   15478311. S2CID   36081296.
  4. Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK (Nov 2004). "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics. 75 (5): 862–872. doi:10.1086/425586. PMC   1182115 . PMID   15386212.

Further reading