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Brigham Young University (BYU) is a private research university in Provo, Utah, United States. It was founded in 1875 by religious leader Brigham Young and is sponsored by the Church of Jesus Christ of Latter-day Saints.
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. It may also be used to decrease the risk of colorectal adenomas in people with familial adenomatous polyposis. It is taken by mouth. Benefits are typically seen within an hour.
Cyclooxygenase-2 inhibitors, also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2 (COX-2), an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration and is the main feature of celecoxib, rofecoxib, and other members of this drug class.
Thomas Robert Cech is an American chemist who shared the 1989 Nobel Prize in Chemistry with Sidney Altman, for their discovery of the catalytic properties of RNA. Cech discovered that RNA could itself cut strands of RNA, suggesting that life might have started as RNA. He found that RNA can not only transmit instructions, but also that it can speed up the necessary reactions.
Professor Michael H. Gelb is an American biochemist and chemist specializing in enzymes and particularly those of medical significance. He is the Boris and Barbara L. Weinstein Endowed Chair in Chemistry at the University of Washington in Seattle. He also teaches Honors Organic Chemistry, Chemical Biology and Enzymology.
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Cyclooxygenase-2 (COX-2), also known as Prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene. In humans it is one of two cyclooxygenases. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, which is expressed in inflammation.
The history of Brigham Young University (BYU) begins in 1875, when the school was called Brigham Young Academy (BYA). The school did not reach university status until 1903, in a decision made by the school's board of trustees at the request of BYU president Benjamin Cluff. It became accredited during the tenure of Franklin S. Harris, under whom it gained national recognition as a university. A period of expansion after World War II caused the student body to grow many times in size, making BYU the largest private university of the time. The school's history is closely connected with its sponsor, The Church of Jesus Christ of Latter-day Saints.
Cyclooxygenase 1 (COX-1), also known as prostaglandin-endoperoxide synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene. In humans it is one of two cyclooxygenases.
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Noel L. Owen is a professor of chemistry at Brigham Young University who served from 1995 to 2001 as associate chair of the Chemistry and Biochemistry Department. He is also a member of BYU's Cancer Research Center.
Research institutes connected with BYU in the present or past include:
Adam T. Woolley is a professor of chemistry at Brigham Young University (BYU) and the recipient of the 2007 Award for young investigators in Separation Science. Woolley and his group are applying microfabrication methods in making microfluidic systems for bioanalysis.
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References
- ↑ Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL (April 1991). "Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing". Proceedings of the National Academy of Sciences of the United States of America. 88 (7): 2692–6. doi: 10.1073/pnas.88.7.2692 . PMC 51304 . PMID 1849272.