Diaminopyrimidine

Last updated June 04, 2025

Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.

Trimethoprim Trimethoprim.svg — Trimethoprim

They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim ^[1] and the antibiotics iclaprim and trimethoprim).

Some have been patented as anti-cancer drugs.^[2]

References

↑ http://aac.asm.org/cgi/content/full/45/12/3293 Archived 2008-08-29 at the Wayback Machine "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
↑ "WO1998030550 - 2,4-DIAMINOPYRIMIDINE COMPOUNDS AS ANTI-CANCER AGENTS". Patentscope. WIPO. Retrieved 2025-06-03.

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[1] ttp://aac.asm.org/cgi/content/full/45/12/3293 Archived 2008-08-29 at the Wayback Machine "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001

[2] "WO1998030550 - 2,4-DIAMINOPYRIMIDINE COMPOUNDS AS ANTI-CANCER AGENTS". Patentscope. WIPO. Retrieved 2025-06-03.

[1]

[2]

Diaminopyrimidine

See also

References