2,4-Diaminopyrimidine

2,4-Diaminopyrimidine ^[1]

Names
Preferred IUPAC name Pyrimidine-2,4-diamine
Identifiers
CAS Number	156-81-0  Y
3D model (JSmol)	Interactive image Interactive image
ChemSpider	60756  Y
ECHA InfoCard	100.005.331
EC Number	205-862-3
PubChem CID	67431
UNII	L5ZY0JJP5J  Y
CompTox Dashboard (EPA)	DTXSID70166021
InChI InChI=1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8) Y Key: YAAWASYJIRZXSZ-UHFFFAOYSA-N Y InChI=1/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8) Key: YAAWASYJIRZXSZ-UHFFFAOYAE
SMILES C1=CN=C(N=C1N)N n1c(N)ccnc1N
Properties
Chemical formula	C4H6N4
Molar mass	110.12 g/mol
Melting point	143 to 147 °C (289 to 297 °F; 416 to 420 K)
Hazards
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

2,4-Diaminopyrimidine is an organic compound with the formula C₄H₂(NH₂)₂. It is the parent of one isomer of the diaminopyrimidines. Such compounds are structurally related to folic acid and the basis of much medicinal chemistry including the drug pyrimethamine. ^[2]

Further reading

• Irvine, Mark William (2020). "Agents acting on pyrimidine metabolism". Antimalarial Agents. pp. 133–185. doi:10.1016/b978-0-08-101210-9.00005-6. ISBN   978-0-08-101210-9.

See also

• 4,5-Diaminopyrimidine

References

1. 2,4-Diaminopyrimidine at Sigma-Aldrich
2. Roth, Barbara; Cheng, C.C. (1982). 6 Recent Progress in the Medicinal Chemistry of 2,4-Diaminopyrimidines. Progress in Medicinal Chemistry. Vol. 19. pp. 269–331. doi:10.1016/s0079-6468(08)70332-1. ISBN   978-0-444-80415-0. PMID   6129679.