Dimethyl sulfoxide (data page)

Last updated January 25, 2024

This page provides supplementary chemical data on dimethyl sulfoxide.

Material Safety Data Sheet

The handling of this chemical may incur notable safety precautions. It is highly recommend that you seek the Material Safety Datasheet (MSDS) for this chemical from a reliable source such as SIRI, and follow its directions.

Structure and properties

Structure and properties
Index of refraction,^[1]n_D	1.4795 at 20 °C 1.4787 at 21 °C
Abbe number	?
Dielectric constant,^[2] ε_r	48 ε₀ at 20 °C
Bond strength	?
Bond length	?
Bond angle	?
Magnetic susceptibility	?
Surface tension ^[2]	43 dyn/cm at 20 °C
Viscosity	2.14 mPa·s^[2] at 20 °C 1.1 mPa·s^[1] at 27 °C

Thermodynamic properties

Phase behavior
Triple point	291.67 K (18.52 °C), ? Pa
Critical point ^[2]	720 K (447 °C), 5630 kPa
Std enthalpy change of fusion, Δ_fusH^o	14.37 kJ/mol
Std entropy change of fusion, Δ_fusS^o	49.26 J/(mol·K)
Std enthalpy change of vaporization, Δ_vapH^o	52.9 kJ/mol
Std entropy change of vaporization, Δ_vapS^o	? J/(mol·K)
Solid properties
Std enthalpy change of formation, Δ_fH^o_solid	? kJ/mol
Standard molar entropy, S^o_solid	? J/(mol K)
Heat capacity, c_p	149.40 J/(mol·K)
Liquid properties
Std enthalpy change of formation, Δ_fH^o_liquid	−203.4 kJ/mol
Standard molar entropy, S^o_liquid	188.78 J/(mol·K)
Enthalpy of combustion, Δ_cH^o	−2037.3 kJ/mol
Heat capacity, c_p	153 J/(mol·K) at 25 °C
Gas properties
Std enthalpy change of formation, Δ_fH^o_gas	−150.5 kJ/mol
Standard molar entropy, S^o_gas	? J/(mol·K)
Heat capacity, c_p	? J/(mol·K)

Vapor pressure of liquid

vapor pressure at 20 °C = 0.556 mbar = 0.417 mmHg^[2]

log10 of dimethyl sulfoxide vapor pressure. Uses formula
log
e
[?]
P
mmHg
=
{\displaystyle \log _{e}P_{\text{mmHg}}={}}
log
e
[?]
760
101.325
-
4.215616
log
e
[?]
(
T
+
273.15
)
-
7522.806
T
+
273.15
+
46.78064
-
2.450859
x
10
-
7
(
T
+
273.15
)
2
{\displaystyle \log _{e}{\frac {760}{101.325}}-4.215616\log _{e}(T+273.15)-{\frac {7522.806}{T+273.15}}+46.78064-2.450859\times 10^{-7}(T+273.15)^{2}}
obtained from CHERIC LogDMSOvaporPressure.png — **log₁₀ of dimethyl sulfoxide vapor pressure.** Uses formula $\log _{e}P_{\text{mmHg}}={}$ $\log _{e}{\frac {760}{101.325}}-4.215616\log _{e}(T+273.15)-{\frac {7522.806}{T+273.15}}+46.78064-2.450859\times 10^{-7}(T+273.15)^{2}$ obtained from CHERIC

Distillation data

BP Temp. °C	% by mole water
Vapor-liquid equilibrium for dimethyl sulfoxide/water^[4] P = 550 mm Hg
BP Temp. °C	liquid	vapor
168.4	6.5	34.6
160.9	10.8	51.8
153.1	16.4	62.7
146.4	21.2	71.0
140.6	26.7	78.4
135.1	32.1	83.9
130.8	37.4	87.6
124.3	44.8	91.7
121.0	48.5	93.5
114.9	55.4	96.0
107.8	66.4	98.0
102.1	74.4	98.9
97.2	84.0	99.6
96.3	85.7	99.6
93.9	91.9	99.8

BP Temp. °C	% by mole DMSO
Vapor-liquid equilibrium for dimethyl sulfoxide/ethanol ^[4] P = 14.665 kPa
BP Temp. °C	liquid	vapor
55.80	48.75	1.0
64.50	59.75	1.6
66.75	64.00	2.5
70.80	71.00	3.6
76.50	76.25	5.0
81.50	80.50	6.0
91.50	85.00	13.0
100.74	90.00	21.0

Spectral data

UV-Vis
λ_max	<220 nm
Extinction coefficient, ε	0.0034 %⁻¹ cm⁻¹ in unpHed water at 260 nm
IR
Spectrum	NIST
Major absorption bands	3000, 2900, 1200–1240, 1000–1080, 960, 690 cm⁻¹
NMR
Proton NMR	2.54((CD₃)₂SO), 2.71 in D₂O;^[5]
Carbon-13 NMR	40ppm;
Other NMR data
MS
Masses of main fragments

References

1 2 Merck Index of Chemicals and Drugs, 9th ed. monograph 3249
1 2 3 4 5 "Dimethyl Sulfoxide (DMSO) -- Technical". Atofina Chemicals, inc. Retrieved 26 May 2007.
↑ "Pure Component Properties" (Queriable database). Chemical Engineering Research Information Center. Retrieved 26 May 2007.
1 2 "Binary Vapor-Liquid Equilibrium Data" (Queriable database). Chemical Engineering Research Information Center. Retrieved 26 May 2007.
↑ Gottlieb, Hugo E. (October 1997). "NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities". The Journal of Organic Chemistry. 62 (21): 7512–7515. doi:10.1021/jo971176v. PMID 11671879.

Linstrom, Peter (1997). "NIST Standard Reference Database". National Institute of Standards and Technology. doi:10.18434/T4D303.{{cite journal}}: Cite journal requires |journal= (help)

This box:

Except where noted otherwise, data relate to Standard temperature and pressure.
Reliability of data general note.

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[merck-1] 1 2 Merck Index of Chemicals and Drugs, 9th ed. monograph 3249

[Atofina-2] 1 2 3 4 5 "Dimethyl Sulfoxide (DMSO) -- Technical". Atofina Chemicals, inc. Retrieved 26 May 2007.

[cheric_p-3] "Pure Component Properties" (Queriable database). Chemical Engineering Research Information Center. Retrieved 26 May 2007.

[cheric_b-4] 1 2 "Binary Vapor-Liquid Equilibrium Data" (Queriable database). Chemical Engineering Research Information Center. Retrieved 26 May 2007.

[5] Gottlieb, Hugo E. (October 1997). "NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities". The Journal of Organic Chemistry. 62 (21): 7512–7515. doi:10.1021/jo971176v. PMID 11671879.

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