Duvernoy's gland

Last updated
Duvernoy's gland (light yellow) on a garter snake from a lateral view. It is lateral to the mouth and caudal to the snake's eye. Partially covered in scales (greenish-brown) and surrounded by underlying muscle tissue (light brown) DG arrow.png
Duvernoy's gland (light yellow) on a garter snake from a lateral view. It is lateral to the mouth and caudal to the snake's eye. Partially covered in scales (greenish-brown) and surrounded by underlying muscle tissue (light brown)

The Duvernoy's gland is a gland found in some groups of colubrid snakes. It is distinguished from the venom gland and is not found in viperids or elapids . It was named for French zoologist Georges Louis Duvernoy who first described the gland in 1832. [1]

Contents

The Duvernoy's gland is positioned posterior to the eye, encased in a thin cover of connective tissue, and consists mostly of serous cells. A single, short duct extends anteromedially from the lumen of the gland to the base of the posterior fangs.

Function

The function of the Duvernoy's gland has been the source of much study and speculation, and debate is still ongoing. It is widely recognized that the Duvernoy's gland is the homologue of venom glands in vipers and elapids. [2] [3] However, the two types of glands are also “anatomically and functionally distinct,” leading experts such as Dr. Kenneth Kardong to maintain the distinction between the Duvernoy's gland and venom glands. [2] [4] Other scientists such as Dr. Bryan Fry maintain that the Duvernoy gland is a primitive version of a venom gland and should be referred to as such. [3] Dr. Stephen Mackessy suggests Duvernoy's gland does secrete venom and is homologous to the venom gland found in front-fanged snakes. [5]

Because the secretions of this gland are associated with the swallowing behavior of snakes, the Duvernoy's gland may play a role in swallowing and/or digestion. [6] Kardong also notes that although some Duvernoy's gland secretions may be toxic and that they can produce pain, swelling, and other effects if injected subcutaneously; this does not make those secretions venoms. [6] [7]

Evolution

The evolutionary path of these separate glands may come from “venom proteins” whose genes are widely expressed in tissues of both venomous and non-venomous snakes. These genes are over-expressed in the venom glands (including Duvernoy's gland), indicating the secretions from these glands evolved separately, rather than sequentially. [5]

Related Research Articles

<span class="mw-page-title-main">Venom</span> Toxin secreted by an animal

Venom or zootoxin is a type of toxin produced by an animal that is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved venom apparatus, such as fangs or a stinger, in a process called envenomation. Venom is often distinguished from poison, which is a toxin that is passively delivered by being ingested, inhaled, or absorbed through the skin, and toxungen, which is actively transferred to the external surface of another animal via a physical delivery mechanism.

<span class="mw-page-title-main">Colubridae</span> Family of snakes

Colubridae is a family of snakes. With 249 genera, it is the largest snake family. The earliest fossil species of the family date back to the Late Eocene epoch, with earlier origins suspected. Colubrid snakes are found on every continent except Antarctica.

<span class="mw-page-title-main">Elapidae</span> Family of venomous snakes

Elapidae is a family of snakes characterized by their permanently erect fangs at the front of the mouth. Most elapids are venomous, with the exception of the genus Emydocephalus. Many members of this family exhibit a threat display of rearing upwards while spreading out a neck flap. Elapids are endemic to tropical and subtropical regions around the world, with terrestrial forms in Asia, Australia, Africa, and the Americas and marine forms in the Pacific and Indian Oceans. Members of the family have a wide range of sizes, from the 18 cm (7.1 in) white-lipped snake to the 5.85 m king cobra. Most species have neurotoxic venom that is channeled by their hollow fangs, and some may contain other toxic components in various proportions. The family includes 55 genera with around 360 species and over 170 subspecies.

<span class="mw-page-title-main">Viperidae</span> Family of snakes

The Viperidae (vipers) are a family of snakes found in most parts of the world, except for Antarctica, Australia, Hawaii, Madagascar, New Zealand, Ireland, and various other isolated islands. They are venomous and have long, hinged fangs that permit deep penetration and injection of their venom. Three subfamilies are currently recognized. They are also known as viperids. The name "viper" is derived from the Latin word vipera, -ae, also meaning viper, possibly from vivus ("living") and parere, referring to the trait viviparity common in vipers like most of the species of Boidae.

<span class="mw-page-title-main">Snakebite</span> Injury caused by bite from snakes

A snakebite is an injury caused by the bite of a snake, especially a venomous snake. A common sign of a bite from a venomous snake is the presence of two puncture wounds from the animal's fangs. Sometimes venom injection from the bite may occur. This may result in redness, swelling, and severe pain at the area, which may take up to an hour to appear. Vomiting, blurred vision, tingling of the limbs, and sweating may result. Most bites are on the hands, arms, or legs. Fear following a bite is common with symptoms of a racing heart and feeling faint. The venom may cause bleeding, kidney failure, a severe allergic reaction, tissue death around the bite, or breathing problems. Bites may result in the loss of a limb or other chronic problems or even death.

<span class="mw-page-title-main">Snake venom</span> Highly modified saliva containing zootoxins

Snake venom is a highly toxic saliva containing zootoxins that facilitates in the immobilization and digestion of prey. This also provides defense against threats. Snake venom is injected by unique fangs during a bite, whereas some species are also able to spit venom.

<span class="mw-page-title-main">Boomslang</span> Species of snake

The boomslang is a highly venomous snake in the family Colubridae. The species is native to Sub-Saharan Africa.

<span class="mw-page-title-main">Envenomation</span> Process of venom injection

Envenomation is the process by which venom is injected by the bite or sting of a venomous animal.

<span class="mw-page-title-main">Perentie</span> Species of lizard

The perentie is a species of monitor lizard. It is one of the largest living lizards on earth, after the Komodo dragon, Asian water monitor, and the Crocodile monitor. Found west of the Great Dividing Range in the arid areas of Australia, it is rarely seen, because of its shyness and the remoteness of much of its range from human habitation. The species is considered to be a least-concern species according to the International Union for Conservation of Nature.

<span class="mw-page-title-main">Toxicofera</span> Proposed clade of scaled reptiles

Toxicofera is a proposed clade of scaled reptiles (squamates) that includes the Serpentes (snakes), Anguimorpha and Iguania. Toxicofera contains about 4,600 species, of extant Squamata. It encompasses all venomous reptile species, as well as numerous related non-venomous species. There is little morphological evidence to support this grouping; however, it has been recovered by all molecular analyses as of 2012.

<i>Boiga dendrophila</i> Species of snake

Boiga dendrophila, commonly called the mangrove snake or the gold-ringed cat snake, is a species of rear-fanged venomous snake in the family Colubridae. The species is endemic to southeast Asia. It is one of the biggest cat snake species, averaging 8–9 feet in length. It is considered mildly venomous. Although moderate envenomations resulting in intense swelling have been reported, there has never been a confirmed fatality.

<i>Rhabdophis subminiatus</i> Species of snake

Rhabdophis subminiatus, commonly called the red-necked keelback or red-necked keelback snake, is a species of venomous snake in the subfamily Natricinae of the family Colubridae. The species is endemic to Asia.

<span class="mw-page-title-main">Venomous snake</span> Species of the suborder Serpentes that produce venom

Venomous snakes are species of the suborder Serpentes that are capable of producing venom, which they use for killing prey, for defense, and to assist with digestion of their prey. The venom is typically delivered by injection using hollow or grooved fangs, although some venomous snakes lack well-developed fangs. Common venomous snakes include the families Elapidae, Viperidae, Atractaspididae, and some of the Colubridae. The toxicity of venom is mainly indicated by murine LD50, while multiple factors are considered to judge the potential danger to humans. Other important factors for risk assessment include the likelihood that a snake will bite, the quantity of venom delivered with the bite, the efficiency of the delivery mechanism, and the location of a bite on the body of the victim. Snake venom may have both neurotoxic and hemotoxic properties. There are about 600 venomous snake species in the world.

<i>Azemiops</i> Genus of snakes

Azemiopinae is a monogeneric subfamily created for the genus Azemiops that contains the viper species A. feae and A. kharini. They are commonly known as Fea's vipers. No subspecies are recognized. The first specimen was collected by Italian explorer Leonardo Fea, and was described as a new genus and new species by Boulenger in 1888. Formerly considered to be one of the most primitive vipers, molecular studies have shown that it is the sister taxon to the pit vipers, Crotalinae. It is found in the mountains of Southeast Asia, in China, southeastern Tibet, and Vietnam. Like all other vipers, they are venomous.

<i>Philodryas olfersii</i> Species of snake

Philodryas olfersii is a species of venomous snake in the family Colubridae. The species is endemic to South America.

<span class="mw-page-title-main">Evolution of snake venom</span> Origin and diversification of snake venom through geologic time

Venom in snakes and some lizards is a form of saliva that has been modified into venom over its evolutionary history. In snakes, venom has evolved to kill or subdue prey, as well as to perform other diet-related functions. While snakes occasionally use their venom in self defense, this is not believed to have had a strong effect on venom evolution. The evolution of venom is thought to be responsible for the enormous expansion of snakes across the globe.

<span class="mw-page-title-main">Three-finger toxin</span> Toxin protein

Three-finger toxins are a protein superfamily of small toxin proteins found in the venom of snakes. Three-finger toxins are in turn members of a larger superfamily of three-finger protein domains which includes non-toxic proteins that share a similar protein fold. The group is named for its common structure consisting of three beta strand loops connected to a central core containing four conserved disulfide bonds. The 3FP protein domain has no enzymatic activity and is typically between 60-74 amino acid residues long. Despite their conserved structure, three-finger toxin proteins have a wide range of pharmacological effects. Most members of the family are neurotoxins that act on cholinergic intercellular signaling; the alpha-neurotoxin family interacts with muscle nicotinic acetylcholine receptors (nAChRs), the kappa-bungarotoxin family with neuronal nAChRs, and muscarinic toxins with muscarinic acetylcholine receptors (mAChRs).

<span class="mw-page-title-main">Three-finger protein</span> Protein superfamily

Three-finger proteins or three-finger protein domains are a protein superfamily consisting of small, roughly 60-80 amino acid residue protein domains with a common tertiary structure: three beta strand loops extended from a hydrophobic core stabilized by disulfide bonds. The family is named for the outstretched "fingers" of the three loops. Members of the family have no enzymatic activity, but are capable of forming protein-protein interactions with high specificity and affinity. The founding members of the family, also the best characterized by structure, are the three-finger toxins found in snake venom, which have a variety of pharmacological effects, most typically by disruption of cholinergic signaling. The family is also represented in non-toxic proteins, which have a wide taxonomic distribution; 3FP domains occur in the extracellular domains of some cell-surface receptors as well as in GPI-anchored and secreted globular proteins, usually involved in signaling.

<span class="mw-page-title-main">Toxungen</span>

Toxungen comprises a secretion or other body fluid of one or more biological toxins that is transferred by one animal to the external surface of another animal via a physical delivery mechanism. Toxungens can be delivered through spitting, spraying, or smearing. As one of three categories of biological toxins, toxungens can be distinguished from poisons, which are passively transferred via ingestion, inhalation, or absorption across the skin, and venoms, which are delivered through a wound generated by a bite, sting, or other such action. Toxungen use offers the evolutionary advantage of delivering toxins into the target's tissues without the need for physical contact.

References

  1. Duvernoy (1832). "Mémoire sur les caractères tirés de l'anatomie pour distinguer les serpents venimeux des serpents non venimeux" [Memory on characters taken from anatomy to distinguish venomous snakes from non-venomous snakes]. Annales des Sciences Naturelles (in French). 26: 113–160.
  2. 1 2 Kardong, Kenneth V. (January 2002). "Colubrid Snakes and Duvernoy's "Venom" Glands". Journal of Toxicology: Toxin Reviews. 21 (1–2): 1–19. doi:10.1081/txr-120004739.
  3. 1 2 Fry, Bryan G.; Wüster, Wolfgang; Ryan Ramjan, Sheik Fadil; Jackson, Timothy; Martelli, Paolo; Kini, R. Manjunatha (30 September 2003). "Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications". Rapid Communications in Mass Spectrometry. 17 (18): 2047–2062. Bibcode:2003RCMS...17.2047F. doi: 10.1002/rcm.1148 . PMID   12955733.
  4. Kardong, Kenneth V. (1996). "Snake Toxins and Venoms: An Evolutionary Perspective". Herpetologica. 52 (1): 36–46. JSTOR   3892954.
  5. 1 2 Mackessy, Stephen P.; Saviola, Anthony J. (November 2016). "Understanding Biological Roles of Venoms Among the Caenophidia: The Importance of Rear-Fanged Snakes". Integrative and Comparative Biology. 56 (5): 1004–1021. doi: 10.1093/icb/icw110 . PMID   27639275.
  6. 1 2 Kardong, Kenneth V. (1982). "The evolution of the venom apparatus in snakes from colubrids to viperids and elapids" (PDF). Memórias do Instituto Butantan. 46: 105–118.
  7. The word "toxic" describes the properties of the substance whereas the word "venom" implies its biological use for the organism.