Eduardo Arzt

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Eduardo Arzt
Arzt e.jpg
Born (1953-02-22) 22 February 1953 (age 71)
Buenos Aires, Argentina
AwardsGuggenheim Fellowship, Houssay award, Bunge y Born award, Konex award
Scientific career
Fields Molecular Biology
Institutions CONICET, Max Planck Society, UBA

Eduardo Arzt (born February 22, 1953) is an Argentine molecular biologist, Master in Experimental Biology, Doctor (Ph.D) from the Faculty of Pharmacy and Biochemistry (University of Buenos Aires). Currently, he is a senior researcher at CONICET, distinguished professor of the Faculty of Natural Sciences of the University of Buenos Aires, External Scientific Member of the Max Planck Society (Germany) and director of the Biomedicine Research Institute of Buenos Aires [1] – CONICET – Partner Institute of the Max Planck Society.

Contents

Contribution and recognition

His scientific contributions stand him out as an internationally recognized personality in the field of molecular neuroendocrinology. His laboratory contributed to the discovery of new genes and pathways involved in the physiological adaptation to homeostasis in response to stress, [2] [3] hypoxia (lack of cellular oxygen), [4] [5] physiopathological processes (pituitary tumors), [6] [7] [8] [9] [10] [11] [12] [13] [14] and to the discovery of new targets for pharmacological treatments. [15] [16] [17] [18]

He is known not only for his findings, which are an example of research in biomedicine, transferring results from basic molecular biology to pharmacological applications, [19] [20] [21] but also for his vast institutional achievements for Argentine and Latin-American science, [22] including an active and important role in the development and realization of the project of the Polo Científico Tecnológico [23] and the creation of the Biomedicine Research Institute of Buenos Aires [24] [25] – CONICET – Partner Institute of the Max Planck Society. He has received, for its ongoing work, both prestigious Argentine (Bunge and Born Award, Houssay Award) and International (Guggenheim Fellowship, External Scientific Member of the Max Planck Society, Order of Merit of the Federal Republic of Germany, Berthold Medal, TWAS Prize) [25] [26] awards and distinctions.

Bibliographic review / career

In 1970 he graduated from the Colegio Nacional de Buenos Aires, Argentina. The following year, he enrolled at the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires, and graduated in 1978.

In 1981 he began a Masters in Experimental Biology at the Universidad Autonoma Metropolitana, Mexico, and his Master's Thesis was on transportation models in biological membranes (1984).

From 1985 to 1988 at the UBA Faculty of Pharmacy and Biochemistry, he conducted his Ph.D. in cellular mechanisms involved in immune-neuroendocrine pathways, at the Institute for Medical Research A. Lanari, of the Faculty of Medicine (UBA).

In 1989 he joined the Scientific Researcher Career of CONICET, Argentina, where he is now a Senior Researcher. [27]

In 1995 he obtained the position of Professor in Molecular and Cellular Biology, Faculty of Natural Sciences (UBA).

In 1997 he participated as co-Founder and Director of the Laboratorio de Fisiología y Biología Molecular (LFBM-FCEN-UBA) [Laboratory of Physiology and Molecular Biology].

In 2005 he was appointed External Scientific Member of the Max Planck Society. [28] [29]

In 2007 he participated in the agreement for the establishment of the Biomedicine Research Institute of Buenos Aires – CONICET – Partner Institute of the Max Planck Society (IBioBA), [1] whose construction was completed in 2012 at the Polo Científico y Tecnológico. [30]

Awards and distinctions

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References

  1. 1 2 Biomedicine Research Institute of Buenos Aires - CONICET - MPSP - official website.
  2. ↑ Refojo D, Echenique C, Müller MB, et al. (April 2005). "Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6183–8. Bibcode:2005PNAS..102.6183R. doi: 10.1073/pnas.0502070102 . PMC   1087957 . PMID   15833812.
  3. ↑ Arzt E, Holsboer F (October 2006). "CRF signaling: molecular specificity for drug targeting in the CNS". Trends in Pharmacological Sciences. 27 (10): 531–8. doi:10.1016/j.tips.2006.08.007. PMID   16935354.
  4. ↑ Druker J, Liberman AC, Antunica-Noguerol M, et al. (June 2013). "RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity". Molecular and Cellular Biology. 33 (11): 2116–27. doi:10.1128/MCB.01470-12. PMC   3648064 . PMID   23508108.
  5. ↑ Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (October 2007). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. hdl: 20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima . PMID   17956732. S2CID   12486303.
  6. ↑ Arzt E, Stelzer G, Renner U, Lange M, Müller OA, Stalla GK (November 1992). "Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures". The Journal of Clinical Investigation. 90 (5): 1944–51. doi:10.1172/JCI116072. PMC   443256 . PMID   1331177.
  7. ↑ Arzt E, Buric R, Stelzer G, et al. (January 1993). "Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6". Endocrinology. 132 (1): 459–67. doi:10.1210/endo.132.1.8419142. PMID   8419142.
  8. ↑ Arzt E, Pereda MP, Castro CP, Pagotto U, Renner U, Stalla GK (January 1999). "Pathophysiological role of the cytokine network in the anterior pituitary gland". Frontiers in Neuroendocrinology. 20 (1): 71–95. doi:10.1006/frne.1998.0176. PMID   9882537. S2CID   42782633.
  9. ↑ Arzt E (December 2001). "gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways". The Journal of Clinical Investigation. 108 (12): 1729–33. doi:10.1172/JCI14660. PMC   209477 . PMID   11748253.
  10. ↑ Giacomini D, Páez-Pereda M, Stalla J, Stalla GK, Arzt E (July 2009). "Molecular interaction of BMP-4, TGF-beta, and estrogens in lactotrophs: impact on the PRL promoter". Molecular Endocrinology. 23 (7): 1102–14. doi:10.1210/me.2008-0425. PMC   5419174 . PMID   19342445.
  11. ↑ Perez-Castro C, Renner U, Haedo MR, Stalla GK, Arzt E (January 2012). "Cellular and molecular specificity of pituitary gland physiology". Physiological Reviews. 92 (1): 1–38. doi:10.1152/physrev.00003.2011. hdl: 11336/68927 . PMID   22298650. S2CID   73834.
  12. ↑ Paez-Pereda M, Giacomini D, Refojo D, et al. (February 2003). "Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 1034–9. Bibcode:2003PNAS..100.1034P. doi: 10.1073/pnas.0237312100 . PMC   298721 . PMID   12552124.
  13. ↑ Arzt E, Chesnokova V, Stalla GK, Melmed S (March 2009). "Pituitary adenoma growth: a model for cellular senescence and cytokine action". Cell Cycle. 8 (5): 677–8. doi:10.4161/cc.8.5.8065. PMC   2710531 . PMID   19223763.
  14. ↑ Antunica-Noguerol, M; Budziñski, M L; Druker, J; Gassen, N C; Sokn, M C; Senin, S; Aprile-Garcia, F; Holsboer, F; Rein, T (2016-05-13). "The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51". Cell Death and Differentiation. 23 (10): 1579–1591. doi:10.1038/cdd.2016.44. ISSN   1476-5403. PMC   5041187 . PMID   27177020.
  15. ↑ Giacomini D, Páez-Pereda M, Theodoropoulou M, et al. (January 2006). "Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action". Endocrinology. 147 (1): 247–56. doi: 10.1210/en.2005-0958 . hdl: 11336/44649 . PMID   16195406.
  16. ↑ Castillo V, Giacomini D, Páez-Pereda M, et al. (September 2006). "Retinoic acid as a novel medical therapy for Cushing's disease in dogs". Endocrinology. 147 (9): 4438–44. doi: 10.1210/en.2006-0414 . hdl: 11336/44644 . PMID   16740975.
  17. ↑ Páez-Pereda, Marcelo; Arzt, Eduardo; Stalla, Günter K (2002). "Cushing's syndrome: Drug targets and therapeutic options". Expert Opinion on Therapeutic Patents. 12 (10): 1537–46. doi:10.1517/13543776.12.10.1537. S2CID   71327660.
  18. ↑ Gerez, J; Tedesco, L; Bonfiglio, J J; Fuertes, M; Barontini, M; Silberstein, S; Wu, Y; Renner, U; Páez-Pereda, M (2014-12-15). "RSUME inhibits VHL and regulates its tumor suppressor function". Oncogene. 34 (37): 4855–4866. doi: 10.1038/onc.2014.407 . hdl: 11336/31656 . ISSN   1476-5594. PMID   25500545.
  19. ↑ Descubren un gen maestro para entender la maquinaria celular, by Nora Bär. Diario La Nación (Argentina), 10/19/2007. (spanish)
  20. ↑ Científicos argentinos hallan un gen maestro para luchar contra el cáncer, by Valeria Román. Diario Clarín (Argentina), 10/19/2007. (spanish)
  21. ↑ Prueban con éxito una terapia para la enfermedad de Cushing, Diario La Nación (Argentina), 10/13/2006.
  22. ↑ Arzt E (November 2012). "Collaboration: Biomedical network in South America". Nature. 491 (7424): 333. Bibcode:2012Natur.491..333A. doi: 10.1038/491333d . hdl: 11336/67883 . PMID   23151571.
  23. ↑ Ciencia entre Palermo Soho y Palermo Hollywood Archived 2014-03-11 at the Wayback Machine , by Paula Rodriguez, Deutsche Welle site, 12/21/2009.
  24. ↑ Primer Mundo, en Palermo: el imponente Instituto Max Planck, by Nora Bär, Diario La Nación(Argentina), 11/26/2012. (spanish)
  25. 1 2 3 Centro Alemán de Información para Latinoamérica y España Archived 2014-03-11 at the Wayback Machine – official website.
  26. 1 2 Orden del Mérito, Página 12 (Argentina), 07/20/2011. (spanish)
  27. ↑ "Comunicación | Conicet". www.conicet.gov.ar (in European Spanish). Retrieved 2017-11-17.
  28. 1 2 Max Planck Institute Psychiatry Munich Archived 2014-03-11 at the Wayback Machine .
  29. 1 2 Importante distinción a dos científicos argentinos, by Nora Bär, Diario La Nación (Argentina), 08/09/2005. (spanish)
  30. ↑ Polo Científico Tecnológico Archived 2012-06-20 at the Wayback Machine - official website. (spanish)
  31. ↑ John Simon Guggenheim Memorial Foundation Archived 2014-02-26 at the Wayback Machine .
  32. ↑ Fundación Bunge y Born Archived 2014-03-11 at the Wayback Machine – web site. Experimental medicine award.
  33. ↑ Premio Bunge y Born a dos investigadores del CONICET, by Nora Bär, Diario La Nación (Argentina), 05/23/2008. (spanish)
  34. ↑ Premio Bunge y Born para un prestigioso investigador, by Valeria Román, Diario Clarín (Argentina), 08/13/2008. (spanish)
  35. ↑ Fundación Konex, official website. Konex award 2013: Molecular Biology and Biochemistry.
  36. ↑ "Prizes and Awards". The World Academy of Sciences. 2016.
  37. ↑ "Eduardo Arzt awarded the Berthold Medal". www.psych.mpg.de. Retrieved 2017-11-17.
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