Elezanumab

Last updated
Elezanumab
Monoclonal antibody
Type ?
Clinical data
Other namesAE12-1Y-QL; ABT-555
Legal status
Legal status
  • Investigational
Identifiers
CAS Number
UNII

Elezanumab (development names AE12-1Y-QL and ABT-555) is a fully human monoclonal antibody developed by AbbVie against repulsive guidance molecule A (RGMa). It has been tested in people with multiple sclerosis and acute ischemic stroke. [1] [2] [3] [4]

References

  1. ↑ Huang, Lili; Fung, Emma; Bose, Sahana; Popp, Andreas; Böser, Preethne; Memmott, John; Kutskova, Yuliya A.; Miller, Renee; Tarcsa, Edit; Klein, Corinna; Veldman, Geertruida M.; Mueller, Bernhard K.; Cui, Yi-Fang (November 2021). "Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models". Neurobiology of Disease. 159: 105492. doi: 10.1016/j.nbd.2021.105492 . PMID   34478849. S2CID   237396110.
  2. ↑ Kalluri, Hari V.; Rosebraugh, Matthew R.; Misko, Thomas P.; Ziemann, Adam; Liu, Wei; Cree, Bruce A. C. (February 2023). "Phase 1 Evaluation of Elezanumab (Anti–Repulsive Guidance Molecule A Monoclonal Antibody) in Healthy and Multiple Sclerosis Participants". Annals of Neurology. 93 (2): 285–296. doi:10.1002/ana.26503. ISSN   0364-5134. PMC   10100020 . PMID   36093738.
  3. ↑ Jacobson, Peer B.; Goody, Robin; Lawrence, Matthew; Mueller, Bernhard K.; Zhang, Xiaomeng; Hooker, Bradley A.; Pfleeger, Kimberly; Ziemann, Adam; Locke, Charles; Barraud, Quentin; Droescher, Mathias; Bernhard, Joerg; Popp, Andreas; Boeser, Preethne; Huang, Lili; Mollon, Jennifer; Mordashova, Yulia; Cui, Yi-Fang; Savaryn, John P.; Grinnell, Christine; Dreher, Ingeborg; Gold, Michael; Courtine, Grégoire; Mothe, Andrea; Tator, Charles H.; Guest, James D. (July 2021). "Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates". Neurobiology of Disease. 155: 105385. doi: 10.1016/j.nbd.2021.105385 . PMID   33991647. S2CID   234683099.
  4. ↑ Smith, Elaine; Ford, Andria L; Perez-Sanchez, Soledad; Shuaib, Ashfaq; Schwefel, Brittany; Ziemann, Adam (February 2022). "Abstract TP7: Phase 2a Study Of Elezanumab In Patients With Acute Ischemic Stroke" . Stroke. 53 (Suppl_1). doi:10.1161/str.53.suppl_1.TP7. ISSN   0039-2499. S2CID   246602705.


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