Elizabeth Jaffee

Last updated
Elizabeth Jaffee
Jaffee, ELizabeth (MASTER - USE FOR ALL).jpg
Elizabeth M. Jaffee, M.D., FACR, FAACP
Born
Alma mater Brandeis University, BSc.
New York Medical College, M.D.
Known for Pancreatic Cancer
Scientific career
Fields Oncology, Immunology, Pathology
InstitutionsPresbyterian-University Hospital, Medical Resident

Johns Hopkins School of Medicine, Professor of Oncology

Contents

American Association for Cancer Research, President-Elect
Sidney Kimmel Comprehensive Cancer Center, Deputy Director
Institute of Clinical and Translational Research, Deputy Director

Elizabeth M. Jaffee is an American oncologist specializing in pancreatic cancer and immunotherapy. [1]

Early life

Jaffee was born in Brooklyn, New York, [2] and her family moved to the neighborhood of Canarsie shortly after. [3] When she was in middle school, the family moved to Huntington on Long Island. [2]

Education

Jaffee completed her undergraduate degree at Brandeis University in 1981, becoming the first woman in her family to have graduated from college, [3] and earned her MD from New York Medical College in 1985. Following medical school, she did her residency at Presbyterian-University Hospital in Pittsburgh, Pennsylvania. [4] After residency she received a position as a research fellow at the University of Pittsburgh. [5]

Career

In 1989, Jaffee started at Johns Hopkins University as a Senior Clinical Oncology Fellow and then went on to become the Assistant Professor of Oncology in 1992. [4] [5] Jaffee works as a medical researcher and deputy director at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center in Baltimore, Maryland. [1] In addition, she is the deputy director of the Institute of Clinical and Translational Research as well as an oncology professor at Johns Hopkins School of Medicine. [1] She is the co-director of the Cancer Immunology Program, the Gastrointestinal Cancers Program, and Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care. [4]

Jaffee takes part in numerous leadership positions. She served as president of the American Association for Cancer Research from 2018 to 2019. [6] In 2019, she was appointed Chief Medical Advisor of the Lustgarten Foundation--the largest private-funder of pancreatic cancer research worldwide. Jaffee also serves as Director of the Foundation's Clinical Accelerator Initiative (CAI), which is designed to quickly move research from the lab to the clinic. She is also involved in the American Society for the Advancement of Science, the American Society of Clinical Oncology, the American Association of Immunologists, the Society of Immunotherapy for Cancer, the Scientific Advisory Board of the Abramson Cancer Center at the University of Philadelphia, the External Advisory Boards of both the Seattle Cancer Consortium Breast SPORE and the University of Pittsburgh Cancer Institute Head and Neck Cancer SPORE. [1]

Jaffee is the deputy director of the Sidney Kimmel Comprehensive Cancer Center, co-director at the Skip Viragh Center for Pancreas Cancer, deputy director of the Institute of Clinical and Translational Research, and professor of oncology and pathology at Johns Hopkins School of Medicine. Her research is focused on immunological treatments for cancer.

Jaffee is the chair of the National Cancer Advisory Board for the National Cancer Institute, of which she has been a member since 2013, and co-chair of the NCI "Blue Ribbon Panel" for the National Cancer Moonshot Initiative. She is a leader of the Stand Up to Cancer Dream Team for pancreatic cancer. [7]

Research

Jaffee’s career is mostly focused on pancreatic cancer treatments. Her main point of interest is using immune therapies to help combat tolerance to cancers. [4] These include utilizing treatments like novel immune checkpoint inhibitors and cancer vaccines. [8] Jaffee is a major leader in cancer vaccine therapy. According to the Boston Globe, Jaffee led a clinical trial on a vaccine, GVAX, that targets pancreatic tumors. With 3 out of the 14 patients in remission, Dr. Jaffee sees a lot of potential in this treatment style for the future. [9] The vaccines would train the body’s immune cells to combat the cancer cells. [10] If the vaccine is successful within a patient, it would prolong their life and prevent the pancreatic cancer from reoccurring for longer periods of time, therefore offering longer remission and a healthier lifestyle for the cancer patient. [8] Furthermore, Jaffee holds 6 vaccine patents, [1] some of which include: Diagnostic Biomarkers and Therapeutic Targets For Pancreatic Cancer, Mesothelin Vaccines and Model Systems, Annexina2 as Immunological Target, and Prostate Stem Cell Antigen Vaccines and Uses Thereof. [1] In 2007, Dr. Elizabeth Jaffee co-authored “Cancer Immunotherapy: Immune Suppression and Tumor Growth”, a publication describing the current understanding of the immune system and its connection between the progression of cancer in the body. [11]

Additionally, Dr. Jaffee has aided in many research discoveries for pancreatic cancer. For instance, genomic and proteomic methods were established to see new signs of pancreatic cancer progression. [1] With further research and development, Jaffee has hopes to make the protein, Annexin A2, not as overworked to prevent the advancement of pancreatic cancer in the body. [1] Throughout her career, Dr. Jaffee has received numerous awards and achievements for her work and effort contributing to cancer research and treatment. Jaffee was the first ever recipient of the Dana and Albert “Cubby” Broccoli Professorship in Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. [4] To continue, she is involved with many institutions including the National Cancer Advisory Board, the NCI NExT SEP Committee, the AACR Cancer Immunology Working Group (CIMM) Steering Committee, the Cancer Vaccine Collaborative (CVC). [1] In 2010 and 2012, Jaffee worked closely as a co-organizer for the AACR Special Conference on Cancer Immunology. [1] Currently, she hopes to incorporate technology, big data, and mathematics into the treatments of pancreatic cancer. [4]

Awards and honors

Related Research Articles

<span class="mw-page-title-main">Steven Rosenberg</span> American cancer researcher

Steven A. Rosenberg is an American cancer researcher and surgeon, chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He pioneered the development of immunotherapy that has resulted in the first effective immunotherapies and the development of gene therapy. He is the first researcher to successfully insert foreign genes into humans.

James L. Gulley is an American cancer researcher and the Director of the Medical Oncology Service at National Cancer Institute.

Nicholas P. Restifo is an American immunologist, physician and educator in cancer immunotherapy. Until July 2019, he was a tenured senior investigator in the intramural National Cancer Institute of the National Institutes of Health at Bethesda, Maryland. Nicholas was an executive vice president of research at Lyell based in San Francisco.

<span class="mw-page-title-main">Larry Kwak</span> American cancer researcher

Larry Kwak is an American cancer researcher who works at City of Hope in Duarte, California and is the Director of the Toni Stephenson Lymphoma Center at City of Hope. Dr. Kwak formerly worked at the University of Texas MD Anderson Cancer Center. He was included on Time's list of 2010's most influential people.

<span class="mw-page-title-main">Lauren V. Wood</span> American allergist, immunologist

Lauren V. Wood is an American allergist, immunologist, and staff physician at the National Cancer Institute (NCI) at the National Institutes of Health (NIH) in Bethesda, Maryland, where she has served as a principal investigator. She is known for conducting studies of vaccines for cancer, Human papillomavirus (HPV), Hepatitis C, and HIV especially for use with children, teens and young adults. She holds the rank of captain in the U.S. Public Health Service (PHS).

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University is an NCI-Designated Comprehensive Cancer Center in Baltimore, MD. It was established in 1973 and received its NCI designation that same year as one of the first designated cancer centers in the country.

Dafna Bar-Sagi is a cell biologist and cancer researcher at New York University School of Medicine. She is the Saul J. Farber Professor in the department of biochemistry and molecular pharmacology and the department of medicine and senior vice president and vice dean for science at NYU Langone Health. Bar-Sagi has been a member of scientific advisory boards, including the National Cancer Institute, Starr Cancer Consortium, and Pancreatic Cancer Action Network.

<span class="mw-page-title-main">Padmanee Sharma</span> American immunologist

Padmanee Sharma is an immunologist and oncologist at the University of Texas MD Anderson Cancer Center in Houston, Texas. She holds the position of professor of genitourinary medical oncology and immunology in the Division of Cancer Medicine where she specializes in renal, prostate, and bladder cancers.

<span class="mw-page-title-main">Crystal Mackall</span> American physician and immunologist

Crystal L. Mackall is an American physician and immunologist. She is currently the Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine at Stanford University. She is the founding director of the Stanford Center for Cancer Cell Therapy.

<span class="mw-page-title-main">Duane Mitchell</span> American physician and research scientist

Duane A. Mitchell is an American physician-scientist and university professor. He is currently employed at the University of Florida College of Medicine, in Gainesville, Florida as the Assistant Vice President for Research, Associate Dean for Translational Science and Clinical Research, and Director of the University of Florida (UF) Clinical and Translational Science Institute. He is the Phyllis Kottler Friedman Professor in the Lillian S. Wells Department of Neurosurgery. and co-director of the Preston A. Wells Jr. Center for Brain Tumor Therapy. Mitchell is also the founder, President, and Chairman of iOncologi, Inc., a biotechnology company in Gainesville, FL specializing in immuno-oncology.

Roy S. Herbst is an American oncologist who is the Ensign Professor of Medicine, Professor of Pharmacology, Chief of Medical Oncology, and Associate Director for Translational Research at Yale Cancer Center and Yale School of Medicine in New Haven, Connecticut.

<span class="mw-page-title-main">Nirali N. Shah</span> American physician-scientist and pediatric hematologist-oncologist

Nirali N. Shah is an American physician-scientist and pediatric hematologist-oncologist, serving as head of the hematologic malignancies section of the pediatric oncology branch at the National Cancer Institute. She researches the translation of immunotherapeutic approaches to treat high-risk hematologic malignancies in children, adolescents and young adults.

Antoni Ribas is a Spanish American physician–scientist. He is a Professor of Medicine, Surgery, and Molecular and Medical Pharmacology at the University of California, Los Angeles (UCLA) and Director of the Tumor Immunology Program at the Jonsson Comprehensive Cancer Center. Ribas served as president of the American Association for Cancer Research (AACR) in 2021–2022.

Suzanne Louise Topalian is an American surgical oncologist. She is the Bloomberg-Kimmel Professor of Cancer Immunotherapy in the Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine. In this role, she studies human anti-tumor immunity.

Nilofer Saba Azad is an American oncologist and physician-scientist specialized in gastrointestinal, colorectal, cholangiocarcinoma, and pancreaticobiliary cancers. She is a professor at the Johns Hopkins School of Medicine and oversees clinical trials at the Sidney Kimmel Comprehensive Cancer Center.

Philip Greenberg is a professor of medicine, oncology, and immunology at the University of Washington and head of program in immunology at the Fred Hutchinson Cancer Research Center. His research is centered around T cell biology and therapeutic cell therapies. He is a co-founder of Juno Therapeutics.

Cornelis Joseph Maria Melief is a immunologuist specialising in cancer immunology and immunotherapy, with a focus on therapeutic cancer vaccines. He is emeritus Professor, former head of the Department of Immunohematology and Blood Transfusion at the Leiden University Medical Center, and Chief Scientific Officer at ISA Therapeutics in Netherlands. He is known for his work in the field of cancer immunology, devising new cancer therapies based on the activation of the patient's own immune system.

Lisa M. Coussens is an American cancer scientist who is Professor and Chair of the Department of Cell, Developmental and Cancer Biology and Deputy Director for Basic and Translational Research in the Knight Cancer Institute at the Oregon Health & Science University. She served as 2022-2023 President of the American Association for Cancer Research.

Julie Renee Brahmer is an American thoracic oncologist. She is the co-director of the Upper Aerodigestive Department within the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University and the Marilyn Meyerhoff Professor in Thoracic Oncology.

Cynthia Louise Sears is an American infectious disease physician-scientist specializing in food borne and intestinal infections. She is a professor of medicine, oncology, molecular biology, and immunology at the Johns Hopkins School of Medicine. She holds the Bloomberg-Kimmel Professorship of Cancer Immunotherapy.

References

  1. 1 2 3 4 5 6 7 8 9 10 "Elizabeth Marion Jaffee, M.D., Professor of Oncology". Johns Hopkins Medicine. Retrieved 2019-10-02.
  2. 1 2 June 3, Ronald Piana; Issue, 2023-Narratives Special. "Finding Early Female Role Models Helped Shape a Notable Career in Oncology". ascopost.com. Retrieved 2024-05-21.{{cite web}}: CS1 maint: numeric names: authors list (link)
  3. 1 2 Neill, Ushma S. (2023-07-03). "A conversation with Elizabeth Jaffee". Journal of Clinical Investigation. 133 (13). doi:10.1172/JCI172246. ISSN   1558-8238. PMC   10313353 . PMID   37395279.
  4. 1 2 3 4 5 6 "AACR Chief Liz Jaffee: New Vision for Cancer Research". www.medpagetoday.com. 2018-06-22. Retrieved 2019-10-02.
  5. 1 2 "Elizabeth Marion Jaffee, M.D."
  6. "Elizabeth M. Jaffee, MD, Named American Association for Cancer Research President-Elect 2017–2018".
  7. "Stand Up To Cancer – Elizabeth M. Jaffee, M.D."
  8. 1 2 Mansour, Joshua (July 19, 2019). "How Viruses Are Being Used to Fight Cancer". U.S. News & World Report. Archived from the original on 2019-07-22.
  9. Saltus, Richard (January 3, 2001). "Results of Study Raise Hopes for Pancreatic Cancer 'Vaccine'". Boston Globe. p. A5. ProQuest   405376120.
  10. LaPook, Jonathan (May 10, 2019). "Researchers hope new vaccine could improve odds for pancreatic cancer". www.cbsnews.com. Retrieved 2019-10-02.
  11. Prendergast, George C.; Jaffee, Elizabeth M. (2007). Cancer Immunotherapy | ScienceDirect. Academic Press/Elsevier. ISBN   9780123725516 . Retrieved 2019-10-02.
  12. "Four from Hopkins elected to National Academy of Medicine". The Hub. Johns Hopkins University. 2019-10-21. Archived from the original on 2019-10-22. Retrieved 2019-10-22.